DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIFC3 and klp2

DIOPT Version :9

Sequence 1:	XP_016878708.1	Gene:	KIFC3 / 3801	HGNCID:	6326	Length:	1079	Species:	Homo sapiens
Sequence 2:	NP_593458.1	Gene:	klp2 / 2543360	PomBaseID:	SPAC664.10	Length:	817	Species:	Schizosaccharomyces pombe

Alignment Length:	870	Identity:	256/870 - (29%)
Similarity:	402/870 - (46%)	Gaps:	178/870 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   219 VLQERLALRDSDQQATSTQLQNQLAEASHPGPPCAPSPCGYQGPGPSPLGGDVDVSGAGRCGVLP 283
            :|:.||:|::.         .|||..|..|.....|                         |.|.
pombe    48 ILKPRLSLQNE---------VNQLKPAKFPSKMLPP-------------------------GSLA 78

Human   284 TLSPPHL--RRCPALGSLSGQNSSDGHPTGDWHDVSCSFDF---SLKVDASLSACWGRDLSTSGS 343
            ::....|  :..|...|.:.:.....||... ..||.|..|   :..|.:||::  ..|:.:...
pombe    79 SVKSSSLAKKARPFTASSNPRMPKSAHPISS-RSVSASSHFGRPASAVSSSLNS--SDDVRSMSD 140

Human   344 QGEPGFMQVEHLKEKLISQAQEVSRLRS-ELGGTDLEK----------------HRDLLMVENER 391
            :....:...:.:....:...::  |||| |:....|..                .:.:.|:| |.
pombe   141 ESMESYNDEKSVNASALRTTED--RLRSMEMAYAQLSAKVIPSPSKRPANYKFYEQRIAMLE-ES 202

Human   392 LRQEMRRCEAELQELRTKPAGPCPGCEHSQESAQLRDKLSQLQLEMAESKG------MLSELNLE 450
            |..|..| .:||||               |.|..||:|......::...||      ||:.:..|
pombe   203 LEVERSR-TSELQE---------------QFSVALREKAEAEANKIVSQKGMESLEIMLNSMKSE 251

Human   451 VQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDSHETIASLRAQSPPVKYVIKTVEVE---SS 512
            ..|:...|.|...|:.:....:.|.|      |:|....|.. :|.|..::|..:....|   |.
pombe   252 NHQRMAMLEENHARVMETAELQHQAE------LQDFASNIEQ-KANSLIMEYKNELQSAEEHFSH 309

Human   513 KTKQALSESQARNQHLQEQVAMQRQVLKEME-------QQLQSSHQLTARLRAQIAMYESELERA 570
            |.|:..||::.:...|||:   :..:||:::       |::|:.|.|..: |.|.|
pombe   310 KIKELTSENELKISRLQEE---KDSLLKKVQEGASLAMQRVQNKHDLEKK-RLQSA--------- 361

Human   571 HGQMLEEMQSLEEDKNRAIEEAFARAQVEMKA---VHENL--------AGVR----TNLLTLQPA 620
                   :|.|:|: |.::::...:.|.|:.:   |.|||        |.|:    || ..|:..
pombe   362 -------IQPLQEE-NNSLKQQIEQLQRELASETVVKENLKSSLDQQSANVQKLESTN-RALEST 417

Human   621 LRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQELLRKYRRELQLRKKCHNEL 685
            ::||..|...:|.::               .|:...::..|.....|:.|...|..||:|.||.:
pombe   418 IKTLEEDVYTMKNKI---------------IELEGILKSANVERDGLVEKLIAEETLRRKLHNTI 467

Human   686 VRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLLHKG----------KPVSFELDK 740
            ..|||||||..||||..   |:|..|..|......:.|.|.::.:.          |..:|..|:
pombe   468 QELKGNIRVFCRVRPPL---GDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQYAFNFDR 529

Human   741 VFSPQASQQDVFQEVQALVTSCIDGFNVCIFAYGQTGAGKTYTMEGTAENPGINQRALQLLFS-E 804
            ||||:.:.:|||.|:..|:.|.:||:|||||||||||:|||:||   :.|.|:...::::::: .
pombe   530 VFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTM---SSNTGMIPSSVRMIYNRS 591

Human   805 VQEKASDWEYTITVSAAEIYNEVLRDLL--GKEPQ---EKLEIRLCPDGSGQLYVPGLTEFQVQS 864
            ...|...|||.:.....|||||.:.|||  |.|.:   :|||| .....:|:..:..:|...:.:
pombe   592 TSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEI-YHDTKAGRTTITNITSEPLDT 655

Human   865 VDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLRTTGKLNLVDLAGSERVGK 929
            .:.:..:.:....||:...||.||||||||::.::.:.|.:.:||......|||:|||||||:..
pombe   656 PEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGETCRSTLNLIDLAGSERLSS 720

Human   930 SGAEGSRLREAQHINKSLSALGDVIAALRS-RQG-HVPFRNSKLTYLLQDSLSGDSKTLMVVQVS 992
            |.:.|.||:|.|.||||||.|||||.||.| ::| ::|:||||||.|||.||.|:|||||.|.:|
pombe   721 SQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYSLGGNSKTLMFVNIS 785

Human   993 PVEKNTSETLYSLKFAERVRSVELG 1017
            |::::..|||.||:||.:|.:.::|
pombe   786 PLKQHVPETLCSLRFATKVNNTQIG 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIFC3	XP_016878708.1	None
klp2	NP_593458.1	GAS	291..470	CDD:290562	49/215 (23%)
		Kinetocho_Slk19	309..399	CDD:289479	26/110 (24%)
		Microtub_bd	452..>480	CDD:293401	14/27 (52%)
		KISc_C_terminal	471..809	CDD:276817	144/344 (42%)
		Kinesin	479..807	CDD:278646	138/334 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0239
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000325
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810