Protein Alignment KIFC3 and klp2

DIOPT Version :10

• Sequence 1: XP_006721251.1
• Gene: KIFC3 / 3801
• HGNCID: 6326
• Length: 1022
• Species: Homo sapiens
• Sequence 2: NP_593458.1
• Gene: klp2 / 2543360
• PomBaseID: SPAC664.10
• Length: 817
• Species: Schizosaccharomyces pombe
• Alignment Length: 888
• Identity: 245/888 - (27%)
• Similarity: 400/888 - (45%)
• Gaps: 208/888 - (23%)

Human   151 LTLQQAL-QDKGCKSQSQ--------GTKEEKLWKRQAP--APRRAREAREAGGTMNVENTGGRL 204
            |:||..: |.|..|..|:        ..|...|.|:..|  |....|..:.|....:...:....
pombe    53 LSLQNEVNQLKPAKFPSKMLPPGSLASVKSSSLAKKARPFTASSNPRMPKSAHPISSRSVSASSH 117

Human   205 FGSRRCSSLSGPPGAAPMVLRMV-EAMSQLQDEKT---------------------QLQEELV-- 245
            || |..|::|....::..|..|. |:|....|||:                     ||..:::
pombe   118 FG-RPASAVSSSLNSSDDVRSMSDESMESYNDEKSVNASALRTTEDRLRSMEMAYAQLSAKVIPS 181

Human   246 ---------VLQERLALRDSD---QQATSTQLQNQVDASLSACWGRDLSTSGSQGEPGFMQVEHL 298
                     ..::|:|:.:..   :::.:::||.|...:|..                  :.|..
pombe   182 PSKRPANYKFYEQRIAMLEESLEVERSRTSELQEQFSVALRE------------------KAEAE 228

Human   299 KEKLISQAQEVSRLRSELGGTDLEKHRDLLMVENERLR----QEMRRCEAELQELRTKPAGPCPG 359
            ..|::|| :.:..|...|.....|.|:.:.|:|....|    .|::. :||||:.
pombe   229 ANKIVSQ-KGMESLEIMLNSMKSENHQRMAMLEENHARVMETAELQH-QAELQDF---------- 281

Human   360 CEHSQESAQLRDKLSQL------QLEMAES--KGMLSELNLEVQQKTDRLAEVELRLKDCLAEKA 416
                  ::.:..|.:.|      :|:.||.  ...:.||..|.:.|..||.|.    ||.|.:|.
pombe   282 ------ASNIEQKANSLIMEYKNELQSAEEHFSHKIKELTSENELKISRLQEE----KDSLLKKV 336

Human   417 QEEERLS-RRLRDSHETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQRQ 480
            ||...|: :|:::.|                    ::|..:.:.|:...|..|..|::|:
pombe   337 QEGASLAMQRVQNKH--------------------DLEKKRLQSAIQPLQEENNSLKQQI----- 376

Human   481 VLKEMEQQLQSSHQLTARLRAQIAMYESELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKA 545
              ::::::|.|...:...|::.:....:.:::.            |..|||:|.
pombe   377 --EQLQRELASETVVKENLKSSLDQQSANVQKL------------ESTNRALES----------- 416

Human   546 VHENLAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQEL 610
                             .::||..|...:|.::               .|:...::..|.....|
pombe   417 -----------------TIKTLEEDVYTMKNKI---------------IELEGILKSANVERDGL 449

Human   611 LRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIHLLHKG- 674
            :.|...|..||:|.||.:..|||||||..||||..   |:|..|..|......:.|.|.::.:.
pombe   450 VEKLIAEETLRRKLHNTIQELKGNIRVFCRVRPPL---GDGESAQIAFPDQNSEASTIEIVAQAP 511

Human   675 ---------KPVSFELDKVFSPQASQQDVFQEVQALVTSCIDGFNVCIFAYGQTGAGKTYTMEGT 730
                     |..:|..|:||||:.:.:|||.|:..|:.|.:||:|||||||||||:|||:||
pombe   512 GSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTM--- 573

Human   731 AENPGINQRALQLLFS-EVQEKASDWEYTITVSAAEIYNEVLRDLL--GKEPQ---EKLEIRLCP 789
            :.|.|:...::::::: ....|...|||.:.....|||||.:.|||  |.|.:   :|||| ...
pombe   574 SSNTGMIPSSVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEI-YHD 637

Human   790 DGSGQLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVDCSTGLR 854
            ..:|:..:..:|...:.:.:.:..:.:....||:...||.||||||||::.::.:.|.:.:||..
pombe   638 TKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGET 702

Human   855 TTGKLNLVDLAGSERVGKSGAEGSRLREAQHINKSLSALGDVIAALRS-RQG-HVPFRNSKLTYL 917
            ....|||:|||||||:..|.:.|.||:|.|.||||||.|||||.||.| ::| ::|:||||||.|
pombe   703 CRSTLNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNL 767

Human   918 LQDSLSGDSKTLMVVQVSPVEKNTSETLYSLKFAERVRSVELG 960
            ||.||.|:|||||.|.:||::::..|||.||:||.:|.:.::|
pombe   768 LQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATKVNNTQIG 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIFC3	XP_006721251.1	SMC_prok_B	294..>618	CDD:274008	59/336 (18%)
		KISc_C_terminal	632..959	CDD:276817	144/344 (42%)
klp2	NP_593458.1	SMC_N	<208..>474	CDD:481474	72/387 (19%)
		KISc_C_terminal	471..809	CDD:276817	144/344 (42%)