DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lov and mod(mdg4)

DIOPT Version :9

Sequence 1:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster
Sequence 2:	NP_788698.1	Gene:	mod(mdg4) / 49228	FlyBaseID:	FBgn0002781	Length:	610	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	105/528 - (19%)
Similarity:	188/528 - (35%)	Gaps:	174/528 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 APQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC 174
            |..:.:||.|||...::...|...|....||||:|......::||::|||.|||||:::|.:.|.
  Fly     2 ADDEQFSLCWNNFNTNLSAGFHESLCRGDLVDVSLAAEGQIVKAHRLVLSVCSPFFRKMFTQMPS 66

  Fly   175 K-HPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVES----SVPEHTPT 234
            . |.::.|.:.....::.::.|||.||::|.|..|...|...||||::||.::    ..|:.:..
  Fly    67 NTHAIVFLNNVSHSALKDLIQFMYCGEVNVKQDALPAFISTAESLQIKGLTDNDPAPQPPQESSP 131

  Fly   235 PAASPD---------------------------DFGMLD-----TSMLSSTFEDECPTMV---RP 264
            |.|:|.                           |.|:.|     |.::..|......|:|   :|
  Fly   132 PPAAPHVQQQQIPAQRVQRQQPRASARYKIETVDDGLGDEKQSTTQIVIQTTAAPQATIVQQQQP 196

  Fly   265 SKGGKLLMPSARLFGNASSAI------------------AALGLRRKREQESDR---DLESDQEL 308
            .:..:.:.......|..::|.                  ::.|::|.:...|..   .|:|..|.
  Fly   197 QQAAQQIQSQQLQTGTTTTATLVSTNKRSAQRSSLTPASSSAGVKRSKTSTSANVMDPLDSTTET 261

  Fly   309 GGSSPMPRRKQARPRRRSGDVPHDFTLN---------KTDAESLQTV---------IKHELLERA 355
            |.::....            ||...|:.         |...:|.|.|         :..||..::
  Fly   262 GATTTAQL------------VPQQITVQTSVVSAAEAKLHQQSPQQVRQEEAEYIDLPMELPTKS 314

  Fly   356 ERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENHHQLELDDE---D 417
            |.|..|  |..::.|:||       .|.||                   ::.:..:..||.   :
  Fly   315 EPDYSE--DHGDAAGDAE-------GTYVE-------------------DDTYGDMRYDDSYFTE 351

  Fly   418 DDDQDHE-------------------EEEEQDIEE--LIHTTNELRRQAAAAAANAAAMSPNPSP 461
            ::|..::                   :::.|:..|  .:.|:.:.....|.||.:|:|....|
  Fly   352 NEDAGNQTAANTSGGGVTATTSKAVVKQQSQNYSESSFVDTSGDQGNTEAQAATSASATKIPP-- 414

  Fly   462 CLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLK-DIRQLNANPNPTAI 525
                       .|:|:.                 .:|::|...:..|..| ....||...:..|:
  Fly   415 -----------RKRGRP-----------------KTKVEDQTPKPKLLEKLQAATLNEEASEPAV 451

  Fly   526 HTPTSCSG 533
            :..|:..|
  Fly   452 YASTTKGG 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lov	NP_611994.3	BTB	130..225	CDD:279045	36/95 (38%)
		BTB	141..226	CDD:197585	32/85 (38%)
		HTH_psq	791..834	CDD:283007
mod(mdg4)	NP_788698.1	BTB	22..118	CDD:279045	36/95 (38%)
		BTB	33..118	CDD:197585	32/84 (38%)
		FLYWCH	452..512	CDD:282369	2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010