DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lov and fru

DIOPT Version :9

Sequence 1:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster
Sequence 2:	NP_001163648.1	Gene:	fru / 42226	FlyBaseID:	FBgn0004652	Length:	960	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	185/884 - (20%)
Similarity:	285/884 - (32%)	Gaps:	348/884 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LPLELPLPLSVQLQLLAKTPTSDHAPMHSTPPTTPPTPPPLPLNMSQSASAVTEAATPENSLPAT 98
            |.|:.|...:::        |...||    ||..||.|.|||            .|:|...:...
  Fly    60 LDLQTPHKRNIE--------TDVRAP----PPPLPPPPLPLP------------PASPSLQISRY 100

  Fly    99 PPSEGALAVPSAPQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSP 163
            ...:||:      ...:.||||||..::.....:||:.:.|.||||.|...:::||:.:||||||
  Fly   101 NTDQGAM------DQQFCLRWNNHPTNLTGVLTSLLQREALCDVTLACEGETVKAHQTILSACSP 159

  Fly   164 FFQRVFAETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSV 228
            :|:.:|.:....||:|.|||.|...:::::||||:||::|.|..|...::..||||||||.:::.
  Fly   160 YFETIFLQNQHPHPIIYLKDVRYSEMRSLLDFMYKGEVNVGQSSLPMFLKTAESLQVRGLTDNNN 224

  Fly   229 PEH-------------TPTPAASPDDF--------GMLD---------------------TSMLS 251
            ..:             :|| ...|.::        |:.|                     |...|
  Fly   225 LNYRSDCDKLRDSAASSPT-GRGPSNYTGGLGGAGGVADAMRESRDSLRSRCERDLRDELTQRSS 288

  Fly   252 STFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGL-------------------------- 290
            |:..:........:.....:   |...||.::|..||||
  Fly   289 SSMSERSSAAAAAAAAAAAV---AAAGGNVNAAAVALGLTTPTGGERSPSVGSASAAAAAAAVAA 350

  Fly   291 ----------------------------------------------------------------- 290

  Fly   351 AVAAAANRSASADGCSDRGSERGTLERTDSRDDLLQLDYSNKDNNNSNSSSTGGNNNNNNNNNNN 415

  Fly   291 ------------------RRKREQESDRDLESDQELGGSSPMPRRKQARPRR------------- 324
                              .|:||:|.:|:.:.|:|| .::|:.:...::.||
  Fly   416 SSSNNNNSSSNRERNNSGERERERERERERDRDREL-STTPVEQLSSSKRRRKNSSSNCDNSLSS 479

  Fly   325 ---------------RSGDVP---------------HDFTLNKTDAESL---------------- 343
                           :|..||               ||..|:.|.:..|
  Fly   480 SHQDRHYPQDSQANFKSSPVPKTGGSTSESEDAGGRHDSPLSMTTSVHLGGGGGNVGAASALSGL 544

  Fly   344 -QTV-IKHELLERAERDQEE----APDQDNSQGEAEKISSSPAKTLV--------ERAKEQKSMK 394
             |:: ||.||::..::.|..    |...|.....|.|:.:....||:        :...|....|
  Fly   545 SQSLSIKQELMDAQQQQQHREHHVALPPDYLPSAALKLHAEDMSTLLTQHALQAADARDEHNDAK 609

  Fly   395 EEGSDQPRSL----------NENHHQLELD---DEDDDDQ--------DHEEE----EEQDIEEL 434
            :...||..::          ::.|...|||   .|.|||.        ||..|    .|.|.||:
  Fly   610 QLQLDQTDNIDGRVKCFNIKHDRHPDRELDRNHREHDDDPGVIEEVVVDHVREMEAGNEHDPEEM 674

  Fly   435 ----IHTTNELRRQAAAAA---ANAAAMSPNPSPCLSDGPEDLCTTK------------KGKELI 480
                .|.|....|:|...|   .:..|.|.:.|....||..: |..|            :.:.::
  Fly   675 KEAAYHATPPKYRRAVVYAPPHPDEEAASGSGSDIYVDGGYN-CEYKCKELNMRAIRCSRQQHMM 738

  Fly   481 SGPS-------SSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGL 538
            |..|       |..||.:....|..:. |||..:.|...::||:.:         |.....|:.|
  Fly   739 SHYSPHHPHHRSLIDCPAEAAYSPPVA-NNQAYLASNGAVQQLDLS---------TYHGHANHQL 793

  Fly   539 LTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVAAAGSGE-----------------HPFHH 586
            ...||....|.....||  |..:.......|.:.:|:.|||..                 .|...
  Fly   794 HQHPPSATHPSHSQSSP--HYPSASGAGAGAGSVSVSIAGSASGSATSAPASVATSAVSPQPSSS 856

  Fly   587 MEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNL 625
            .......:.|.||||||...|        ||||...|.|
  Fly   857 STGSTSSAAAVAAAAAAAANR--------RDHNIDYSTL 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lov	NP_611994.3	BTB	130..225	CDD:279045	42/94 (45%)
		BTB	141..226	CDD:197585	39/84 (46%)
		HTH_psq	791..834	CDD:283007
fru	NP_001163648.1	BTB	126..221	CDD:279045	42/94 (45%)
		BTB	137..221	CDD:197585	39/83 (47%)
		C2H2 Zn finger	901..918	CDD:275368
		C2H2 Zn finger	925..944	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020