DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lov and chinmo

DIOPT Version :9

Sequence 1:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster
Sequence 2:	NP_001188680.1	Gene:	chinmo / 33343	FlyBaseID:	FBgn0086758	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	906	Identity:	186/906 - (20%)
Similarity:	275/906 - (30%)	Gaps:	326/906 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETP-- 173
            ||..:.|:||:..:::...|..|.|:..|.||.|.|.....:|||::|:|||..|..:|..||
  Fly     3 PQQQFCLKWNSFSSNLAITFSNLFKSDLLADVILSCDGVVFKAHKLILAACSKKFADLFENTPTN 67

  Fly   174 --CKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESS--------- 227
              |   ||:|:......:.|:::|||:||:.|.|:.|.:.:::.|||||:||...:
  Fly    68 GQC---VIILEATTPDNMAALLEFMYKGEVHVSQEALNSFLKSAESLQVKGLSTETGRLAAQQAQ 129

  Fly   228 ------VPEHTPTPAAS-------------PDDFGM----------------------------- 244
                  .|..:||...|             |...|:
  Fly   130 QHMGDLSPLDSPTGRRSVRNSLSGGSSSIVPGGVGIGLGGGATGANSMSGMGIGNGLSLAGMAAG 194

  Fly   245 -------------LDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIA---------- 286
                         |.|...|:...|.|     .|.|..::..||...|.:.|..|
  Fly   195 GGMAAAANAAASSLSTLAASANIVDRC-----GSAGANIISGSAAGIGGSHSGGAGNGSGTVGIG 254

  Fly   287 ----------------------------ALGLRRKREQESDRDLESDQELGGSS----------- 312
                                        :.|:.:   ||.|    |....||||
  Fly   255 GNGVGSGGGNNGPISLGSGAGAAHHLGGSTGILK---QECD----SLMHPGGSSSSSGMGYTHVP 312

  Fly   313 PMPRRKQARPRRRSGDVPHDFTLNKTDAESLQTVIKHELLERAERDQEEAPDQDNS------QGE 371
            |:.|.....|.|:...|...:    ::.|...:|:      |......|.|...|.      ...
  Fly   313 PIYRPINYEPPRKRAIVRSPY----SEQEQRGSVL------RDGSKSSECPSPINKPPYHRPSSS 367

  Fly   372 AEKISSSPAKTL-VERAKEQKSMKEEGSDQPRSLNEN------------HHQLELDDEDDDDQDH 423
            |...:.:.|.|: .|||..|.|..|..|....:.|.|            .:....::.:|||::.
  Fly   368 ASSTAPTEADTMHSERASPQSSRYENHSPSTTAGNGNATSSLERIVKSERNNGSANEANDDDREL 432

  Fly   424 EEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCL----SDG-----------PEDLCTT 473
            .:|...:..|.:....|..:.:.....|:...|..|:..|    :||           |.|:...
  Fly   433 MDESTDNGAEDLRVKLENLKYSPPPPPNSNTSSTTPNTLLENLKADGTLSSNLAASIAPADMLNV 497

  Fly   474 KKGKELISGPSSSADCESNNNNSSKLQDNNQRIML----------SLK-DIRQLNAN---PNPTA 524
            ....::            ||.||....|..:...|          :|: .|||.:..   |.|..
  Fly   498 WNATKM------------NNKNSVNTADGKKLKCLYCDRLYGYETNLRAHIRQRHQGIRVPCPFC 550

  Fly   525 IHTPTSCSGGNN--------------GLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAAVA 575
            ..|.|.    ||              ||..         |...: |.|:.|.     |||:||..
  Fly   551 ERTFTR----NNTVRRHIAREHKQEIGLAA---------GATIA-PAHLAAA-----AAASAAAT 596

  Fly   576 AAGSGEHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPM----------- 629
            ||.|...| .          |||.|||::.....::....|........|...|
  Fly   597 AAASNHSPXE----------AAATAAASVVMNANKEAAKQRKRKTLKMALEKCMQRRDAMVAETT 651

  Fly   630 -GMPPFGGHNGGHPGNSGPGNGCPGQAAHE-----RLEESMNRLSKELGKEFGKEFGKEFGKEFG 688
             |....|...||..|.:..|.|....|..|     ..|:...|:.:||.::.......|...|
  Fly   652 TGAGGDGAEAGGESGEAVDGAGSEEGAGSEGTEPLTYEQQQQRMHQELTQQIRAAMAAEQAAE-- 714

  Fly   689 PASPMSLQGPFN-----------------------APDGPPHP------PSPLPFPGMSSAMTLT 724
             |...::....|                       |.||...|      ..|.|.||  |.:.:.
  Fly   715 -AMDSTMNTTVNTTTTTTTTTNTTGATSDGCSDAEASDGSDRPMEVDEDQPPEPQPG--SELVVV 776

  Fly   725 PP---------------HMFGLDSPLGLFPPGIDPGKLYN--PLMEMSDPRDMPGGPPPFL 768
            .|               ||...:       |.|....:|:  |....|.|..:|....|.|
  Fly   777 EPKIEVLSESEDEEDRLHMSEAE-------PDIQAEAIYDHMPNTPTSPPHIIPPNDTPTL 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lov	NP_611994.3	BTB	130..225	CDD:279045	39/98 (40%)
		BTB	141..226	CDD:197585	35/88 (40%)
		HTH_psq	791..834	CDD:283007
chinmo	NP_001188680.1	BTB	22..116	CDD:279045	37/96 (39%)
		BTB	33..116	CDD:197585	33/85 (39%)
		C2H2 Zn finger	519..540	CDD:275368	5/20 (25%)
		C2H2 Zn finger	547..568	CDD:275368	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020