DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lov and CG3726

DIOPT Version :9

Sequence 1:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster
Sequence 2:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	900	Identity:	186/900 - (20%)
Similarity:	293/900 - (32%)	Gaps:	317/900 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 PQDHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC- 174
            || .|.|||..|.:::...|..||......||||.|....||||::||.|||.||..|.:....
  Fly     3 PQ-QYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASE 66

  Fly   175 KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESS--VPEHTPTPAA 237
            :.|:|::||.....|:.:::|||:|||:|....|.:|::..:.|:::||.|.:  ..|..|.|..
  Fly    67 RDPIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDEDGPPPPM 131

  Fly   238 SPDDFGMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSAIAALGLRRKREQESDRD- 301
            :..:|.....|:..|..:|......:..:.|....|.     |..|:.|.|...|:||:|.||:
  Fly   132 AAAEFHSPPRSLAESYAQDLILQHQQQQQQGPAAPPL-----NLHSSAALLERDRERERERDRER 191

  Fly   302 -----------------------------LESDQELGGSSPM-----PRRKQARPRRRSGDVPHD 332
                                         :.....|.|.:|:     |:||:.||..   |..:|
  Fly   192 LSPGMEGVLGRMPVMTPLTGASGSAGVGSVSGGTSLEGVAPVEHFLGPKRKRGRPPL---DDAYD 253

  Fly   333 -FTLNKTD--AESLQTVIKHELLERAERDQEEAPDQDNSQGEAEKISSSPAKTLVERAKEQKSMK 394
             |.:.|..  |.:|:.. :...||.|....||.|    ....|..::|.||..   ..|:::.::
  Fly   254 VFNVRKLAQYAANLEPA-QRAYLETARHFTEEPP----LAAHAASMASPPAAC---PPKQRQRLR 310

  Fly   395 EEGSDQPRSLNENHHQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNP 459
            .:...|.:.|                |....::||                .||..:.:.:.||.
  Fly   311 HQQQQQQQLL----------------QSESSDQEQ----------------PAAGQDWSNLEPNG 343

  Fly   460 S---PCLSDGPEDLCTTKKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPN 521
            |   ..||||..:...|:.|.|.:....::|. .|......|:.:..:| ...|:..|:|.....
  Fly   344 SATPKLLSDGDANKQETEGGDESLPAVLTTAS-SSGTKKLEKIGERRER-HGKLRHARRLYEKSG 406

  Fly   522 PTAIHTPTSCSGGNNGLLTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAAAA------------- 573
            ...:..|..                    .||..|..:|.:|.: |..|..|
  Fly   407 EDEVDPPKE--------------------EPDELPQPVEEIENE-HLVANRAESPRPTVVIPASF 450

  Fly   574 -------VAAAGSG-----------------EHPFHHMEHQMEMSLAAAAAAAAMHQREPRDPRD 614
                   |.|||.|                 ||.. .|.|:...::|:|||.||:
  Fly   451 ACKYEGGVTAAGGGSGSGTGSGSLGSSYLINEHGM-LMAHEFAPNVASAAATAAV---------- 504

  Fly   615 GRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGPGNGCPGQAAHERLEE----SMNRLSKELGKEF 675
                 |.|: ....:.....|..|||. ..||.|.|........:||:    .:...::||.:
  Fly   505 -----AVAA-AAAAVANASAGNGNGGQ-DVSGSGTGAAADYPDIKLEDYDAAELRLTNEELSQ-- 560

  Fly   676 GKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPPSPLPFPGMSSAMTLTPPHMFGLDSPLGLFPP 740

  Fly   561 ----------------------------------------------------------------- 560

  Fly   741 GIDPGKLYNPLMEMSDPRDMPGGPPPFLKKKMPRPKGQHSAPRGGPPRSWTNTELTEALQHVWNK 805
                   :..:::|.|          :|.|             |..|:.|........|..:.||
  Fly   561 -------WQDVIKMDD----------YLAK-------------GRRPQFWEEPFTKRVLDAIKNK 595

  Fly   806 KMTTSQASRIFGIPYNSLLMYVRGKYGKSLKLEQLRKDCISGPPIEMLQMGIGGGSGGSTKNEKS 870
            ::...:|:||.|:.|.:|....|..||           |:..|           .||.:.:|
  Fly   596 RLEMKKAARILGVSYGTLYGRYREVYG-----------CLKHP-----------YSGTAFRN--- 635

  Fly   871 KERKEKEKDKNSMSSNGSGGSANSQGGAPTSGSGPMQHSGELG---PMGQLDLDL 922
                             ||.::.||.|.........::.|.|.   .:|:|..||
  Fly   636 -----------------SGSTSTSQMGVQPRFDLGFRNGGVLPAQLELGKLKKDL 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lov	NP_611994.3	BTB	130..225	CDD:279045	37/95 (39%)
		BTB	141..226	CDD:197585	34/85 (40%)
		HTH_psq	791..834	CDD:283007	12/42 (29%)
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	37/96 (39%)
		BTB	32..121	CDD:197585	35/88 (40%)
		HTH_psq	587..622	CDD:283007	10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10232
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020