DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lov and ZBTB12

DIOPT Version :9

Sequence 1:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster
Sequence 2:	NP_862825.1	Gene:	ZBTB12 / 221527	HGNCID:	19066	Length:	459	Species:	Homo sapiens

Alignment Length:	314	Identity:	62/314 - (19%)
Similarity:	98/314 - (31%)	Gaps:	127/314 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCK-------HPVI 179
            |:...||..:.|...:...|||:|......|.||::|:|||||.:..|...|..       |...
Human    15 HEAATLRNMNQLRAEERFCDVTIVADSLKFRGHKVILAACSPFLRDQFLLNPSSELQVSLMHSAR 79

  Fly   180 VLKD-----FRG---WVVQAIVDFMYRGE-------ISVPQQRLQTLIQAGESLQVRGLVESSV- 228
            ::.|     :.|   :.|:.||:::....       :...:..|...|:....|:..|:.|:|:
Human    80 IVADLLLSCYTGALEFAVRDIVNYLTAASYLQMEHVVEKCRNALSQFIEPKIGLKEDGVSEASLV 144

  Fly   229 -----------PEHTPTPAASPD---------------DFGMLDTSMLSSTFEDE---------C 258
                       |..||.||..|.               :|.:.:...|.:..|||         |
Human   145 SSISATKSLLPPARTPKPAPKPPPPPPLPPPLLRPVKLEFPLDEDLELKAEEEDEDEDEDVSDIC 209

  Fly   259 -------------------------------------------PTMVRPSKG------------- 267
                                                       |:.|.|.:|
Human   210 IVKVESALEVAHRLKPPGGLGGGLGIGGSVGGHLGELAQSSVPPSTVAPPQGVVKACYSLSEDAE 274

  Fly   268 --GKLLMPSARLFGNASSAI---AALGLRRKREQESDRDLESDQELGGS-SPMP 315
              |.||:|..|....|:|.:   ||:.:       :.|........||| .|:|
Human   275 GEGLLLIPGGRASVGATSGLVEAAAVAM-------AARGAGGSLGAGGSRGPLP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lov	NP_611994.3	BTB	130..225	CDD:279045	26/116 (22%)
		BTB	141..226	CDD:197585	25/106 (24%)
		HTH_psq	791..834	CDD:283007
ZBTB12	NP_862825.1	BTB	23..127	CDD:306997	23/103 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..179		6/25 (24%)
		C2H2 Zn finger	335..355	CDD:275368
		zf-C2H2	359..381	CDD:306579
		COG5048	<361..>448	CDD:227381
		C2H2 Zn finger	361..381	CDD:275368
		C2H2 Zn finger	389..409	CDD:275368
		C2H2 Zn finger	417..435	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000