DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and PJA2

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_055634.3	Gene:	PJA2 / 9867	HGNCID:	17481	Length:	708	Species:	Homo sapiens

Alignment Length:	196	Identity:	51/196 - (26%)
Similarity:	77/196 - (39%)	Gaps:	38/196 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 NIGQDLSLT--LDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQR 260
            |:..|.|::  ||..:::.....:|......||        :|...|:..|.:           .
Human   535 NLEDDSSVSEDLDVDWSLFDGFADGLGVAEAIS--------YVDPQFLTYMAL-----------E 580

  Fly   261 FRYMQAKDQQSRNLCSV-----------TKKAIMKIPTKTGKFSDEKDLDSD-CCAICIEAYKPT 313
            .|..||.:....:|.|:           :|::|..:| :|....|...:..: ||.||...|...
Human   581 ERLAQAMETALAHLESLAVDVEVANPPASKESIDGLP-ETLVLEDHTAIGQEQCCPICCSEYIKD 644

  Fly   314 DTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYGYVFLGSEESILEYQPD-PPQGLALVE 377
            |....|||.|.|||.|:..||.:..|||:|:   ..|...|...|.....|..|| ||...::.|
Human   645 DIATELPCHHFFHKPCVSIWLQKSGTCPVCR---RHFPPAVIEASAAPSSEPDPDAPPSNDSIAE 706

  Fly   378 A 378
            |
Human   707 A 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	5/20 (25%)
		UPF0233	226..>258	CDD:299753	5/31 (16%)
		zf-RING_2	301..344	CDD:290367	19/43 (44%)
PJA2	NP_055634.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..90
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..317
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..495
		Interaction with PRKAR1A, PRKAR2A and PRKAR2B. /evidence=ECO:0000269\|PubMed:21423175	531..708		51/196 (26%)
		zf-RING_2	634..675	CDD:290367	18/40 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..708		8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910