Protein Alignment gol and RNF128

DIOPT Version :10

• Sequence 1: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_919445.1
• Gene: RNF128 / 79589
• HGNCID: 21153
• Length: 428
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 105/304 - (34%)
• Similarity: 160/304 - (52%)
• Gaps: 43/304 - (14%)

  Fly    70 AFLNWSY-VEHGNMLCNMEFAQEQARYGEGKVLN-VTGRLIHITATDNFSDDYACTPYIRGTL-- 130
            |:||.|: |.|..:...:....|:..||:...|. |.|.|:   ..|......||.|:...|:
Human    45 AYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLV---PPDGPGALNACNPHTNFTVPT 106

  Fly   131 --GAPIPDKGETWIALVRR-GRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRN--- 189
              |:.:.   .:|:||::| |.|||.:|:...|::.|:|.:|:|           ..| |||
Human   107 VWGSTVQ---VSWLALIQRGGGCTFADKIHLAYERGASGAVIFN-----------FPG-TRNEVI 156

  Fly   190 ---------IAAVITYQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVL 245
                     |.|::.....|..:..::.:|..||:.|..|::....:   |..|:.|||:||.::
Human   157 PMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWV---NHYSIFFVSVSFFII 218

  Fly   246 MIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDL--DSDCCAICIE 308
            ...::.:.|||..:|.|..:|:.::.|.|.:..||||.::..:|.|..| |::  |.|.||:|||
Human   219 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGD-KEIGPDGDSCAVCIE 282

  Fly   309 AYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYG 352
            .|||.|.:|||.|.|.|||.|:||||:|||||||||.|:||..|
Human   283 LYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	41/162 (25%)
		HRD1	<237..>347	CDD:227568	54/111 (49%)
		RING-H2_RNF130-like	302..347	CDD:438330	31/44 (70%)
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	41/162 (25%)
		RING-H2_RNF128-like	275..323	CDD:438454	33/47 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..428