DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and znrf3

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	257	Identity:	60/257 - (23%)
Similarity:	114/257 - (44%)	Gaps:	44/257 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 GAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKT-----RNI 190
            ||.|..:||. :.:...|.|...:: :.:|:....||:.....::.....:.:.||.     |..
Frog    62 GATISAEGEI-VQMHPLGLCNNNDE-EDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGA 124

  Fly   191 AAVITYQNIGQDLSLTLDKGYNVTIS----IIEGRRGVRTISSLNR----------------TSV 235
            .|||...:...|....|::|....:.    .::|...::.::.:|:                |..
Frog   125 TAVIFDVSDNPDAVEQLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEY 189

  Fly   236 LFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDLDS 300
            ..:.|.....:::|||.||.  :.:.:..|.:.|.|.|..:|  :|:.|:.|:..|...:...:.
Frog   190 FDMGIFLAFFVVVSLVCLIL--LIKIKLKQRRSQNSMNRMAV--QALEKMETRKFKAKGKVPREG 250

  Fly   301 DC-------------CAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCKLDVLK 349
            .|             ||||:|.|...:.:|::||.|.|||.|:||||:::.|||.|:.::::
Frog   251 SCGGLDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIE 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	19/94 (20%)
		UPF0233	226..>258	CDD:299753	8/47 (17%)
		zf-RING_2	301..344	CDD:290367	22/55 (40%)
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	16/106 (15%)
		RING-H2_ZNRF3	266..309	CDD:319713	22/42 (52%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	21/39 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920