DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and Znrf3

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_038948772.1	Gene:	Znrf3 / 685487	RGDID:	1593771	Length:	913	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	112/511 - (21%)
Similarity:	196/511 - (38%)	Gaps:	155/511 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SDDYACTPYIRG------TLGAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQV 175
            |.||  |.:..|      ..||.:..:||. :.:...|.|...:: :.:|:....||:.....::
  Rat    68 SGDY--TTHTTGLTGRFSRAGAMLSAEGEI-VQMHPLGLCNNNDE-EDLYEYGWVGVVKLEQPEL 128

  Fly   176 MQLEKMQIKGKT-----RNIAAVITYQNIGQDLSLTLDKG----YNVTISIIEGRRGVRTISSLN 231
            .....:.:.||.     |...|||...:...:....|::|    ....:..::|...|:.::.:|
  Rat   129 DPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAVKLMNIVN 193

  Fly   232 RTSV------------------LFVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVT 278
            :..|                  :.:.::|.|  ::|||.||.  :.:.:..|.:.|.|.|..:|
  Rat   194 KQKVARARIQHLPPRQPTEYFDMGIFLAFFV--VVSLVCLIL--LVKIKLKQRRSQNSMNRLAV- 253

  Fly   279 KKAIMKIPTKTGKFSDEKD---------LD-------SDCCAICIEAYKPTDTIRILPCKHEFHK 327
             :|:.|:.|:  ||:.:..         ||       || ||||:|.|...:.:|::||.|.||:
  Rat   254 -QALEKMETR--KFNSKSKGRREGSCGALDTLSSGSTSD-CAICLEKYIDGEELRVIPCTHRFHR 314

  Fly   328 NCIDPWLIEHRTCPMCKLDVLKFYGYVFLGSEESILEYQPDPPQGLALVEARDESADLNRSRDFV 392
            .|:||||::|.|||.|:               .:|:|.:.:|  |...|    |:::|.|.|
  Rat   315 KCVDPWLLQHHTCPHCR---------------HNIIEQKGNP--GAVCV----ETSNLTRGR--- 355

  Fly   393 VDFPRVFVLDSGCVVGAREMLFPCRI---------PERSQSSLSLRQARDWVSLMSNKLEEQQGL 448
              .|||.:          .:.:|.|:         |.|:    |:....:.|:|::.....:|.|
  Rat   356 --HPRVTL----------PVHYPGRVHRTNAIPAYPTRT----SMDSHGNPVTLLTMDRHGEQNL 404

  Fly   449 RSMRND---------EMQQQLLSARESARH---------RRSRSADGRYS-TGCFG--------- 485
            .|.:..         .:...|...|.|..|         ||.:.:...:| ..||.
  Rat   405 YSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSSRSFSKAACFSQYETMYQHY 469

  Fly   486 --------GRQRQPSVLVSSLGQPQLHSEVAQMQRSNSS---QALKHLTDAAHAQS 530
                    .::.||...|:..||.:     |......||   ..:.|:...||.:|
  Rat   470 YFQGLSYPEQESQPVPSVTPRGQSR-----AFPPSGGSSLLFPTMVHMAPPAHVES 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	22/114 (19%)
		UPF0233	226..>258	CDD:299753	9/49 (18%)
		zf-RING_2	301..344	CDD:290367	22/42 (52%)
Znrf3	XP_038948772.1	ZNRF_3_ecto	98..204	CDD:408039	17/106 (16%)
Znrf3	XP_038948772.1	RING-H2_ZNRF3	289..333	CDD:319713	23/59 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010