DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and PJA1

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001369704.1	Gene:	PJA1 / 64219	HGNCID:	16648	Length:	643	Species:	Homo sapiens

Alignment Length:	240	Identity:	54/240 - (22%)
Similarity:	90/240 - (37%)	Gaps:	59/240 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 GAPIPDKGETWIALVR-----RGRCTFEE-KVKHV-YQQNAAGVIIYNDK--QVMQLEKMQIKGK 186
            ||.....|..::..||     ..:.:.|| ::..: |.:|.:.....||.  ::||.....:.|.
Human   430 GASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGN 494

  Fly   187 TRNIAAVITYQNIGQDLSLTLDKGYNVTISIIEG-RRGVRTISSLNRTSVLFVSISFIVLMIISL 250
                      .|:..|.|::.|  ..|..|:.:| ..|:....:::     :|...|:..|.:
Human   495 ----------NNLEDDSSVSED--LEVDWSLFDGFADGLGVAEAIS-----YVDPQFLTYMAL-- 540

  Fly   251 VWLIFYYIQRFRYMQAKDQQSRNLCSV-----------TKKAIMKIP-----TKTGKFSDEKDLD 299
                     ..|..||.:....:|.|:           :|::|..:|     ...|....|.
Human   541 ---------EERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEM--- 593

  Fly   300 SDCCAICIEAYKPTDTIRILPCKHEFHKNCIDPWLIEHRTCPMCK 344
              ||.||...|...:....|||.|.|||.|:..||.:..|||:|:
Human   594 --CCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	19/94 (20%)
		UPF0233	226..>258	CDD:299753	3/31 (10%)
		zf-RING_2	301..344	CDD:290367	18/42 (43%)
PJA1	NP_001369704.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..363
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..454		5/23 (22%)
		RING-H2_PJA1_2	594..639	CDD:319379	19/43 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910