DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and RNF130

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_024301897.1	Gene:	RNF130 / 55819	HGNCID:	18280	Length:	448	Species:	Homo sapiens

Alignment Length:	290	Identity:	125/290 - (43%)
Similarity:	170/290 - (58%)	Gaps:	10/290 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 YNYAFLNWSYVEHGNMLCNMEFAQEQARYG-EGKVLNVTGRLIHITATDNFSDDYACTPYIRGTL 130
            |..|.:|.:..|.|.. ..:.|..::.||| :.....|.|:::........:|...|.|..|..
Human    34 YYTALINVTVQEPGRG-APLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFF- 96

  Fly   131 GAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVIT 195
               :|...:.||||::||.|||:||:......||..|:|||:|...:...|...| |.:|.||:.
Human    97 ---VPPNIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPG-TGDIIAVMI 157

  Fly   196 YQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQR 260
            .:..|:|:...|:|..:|.::|..|.|  ....:.:|.|::|||||||||||||..|||||:||:
Human   158 TELRGKDILSYLEKNISVQMTIAVGTR--MPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQK 220

  Fly   261 FRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSD-EKDLDSDCCAICIEAYKPTDTIRILPCKHE 324
            .||..|:|:..|.|....||||.|:.|:|.|..| |.|.|.|.||:|||:||..|.:|||||||.
Human   221 IRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHV 285

  Fly   325 FHKNCIDPWLIEHRTCPMCKLDVLKFYGYV 354
            |||:|:||||.||.|||||||::||..|.|
Human   286 FHKSCVDPWLSEHCTCPMCKLNILKALGIV 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	43/144 (30%)
		UPF0233	226..>258	CDD:299753	20/31 (65%)
		zf-RING_2	301..344	CDD:290367	30/42 (71%)
RNF130	XP_024301897.1	PA_GRAIL_like	40..179	CDD:239037	43/144 (30%)
		zf-rbx1	<197..>306	CDD:331150	69/108 (64%)
		RING_Ubox	262..310	CDD:327409	33/47 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7788
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3586
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm41809
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	11.060