DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and Rnf43

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	121/560 - (21%)
Similarity:	197/560 - (35%)	Gaps:	153/560 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GEGKVLNVTGRLI--HITATDNFSDDYACTPYIRGTLGAPIPDKGETWIALVR--------RGRC 150
            |..:|....|:|:  |.....|.|||....|               .:|::|:        |...
  Rat    71 GVAEVSPAEGKLMQSHPLYLCNASDDDNLEP---------------GFISIVKLESPRRAPRPCL 120

  Fly   151 TFEEKVKHVYQQNAAGVI--IYNDKQVMQLEKMQIKGKTRNIAAVITYQNIGQDLSLTLDKGYNV 213
            :...|.:...::.|:.|:  |..|:...: :..|..|.|:.:..:     .|.|....::..|.
  Rat   121 SLASKARMAGERGASAVLFDITEDRSAAE-QLQQPLGLTKPVVLI-----WGSDAEKLMEFVYK- 178

  Fly   214 TISIIEGRRGVRTISSLNRTSVLFVSIS----------FIVLMIISLVW-LIFYYIQRFRYMQAK 267
                             ||.:.:::.:.          :|:|.::..|: :|...:.|.|   .:
  Rat   179 -----------------NRKAYVWIELKEPPAWANYDVWILLTVVGTVFVIILASVLRIR---CR 223

  Fly   268 DQQSR--NLCSVTKKAIMKIPTK---------TGKFSDEKDLDSDC--CAICIEAYKPTDTIRIL 319
            ...||  .|...|.:||.::.|:         ..::.|.....|..  ||||:|.:.....:|::
  Rat   224 PHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWPDSGSSSSSAPVCAICLEEFTEGQELRVI 288

  Fly   320 PCKHEFHKNCIDPWLIEHRTCPMCKLDVLKFYGYVF---LGSEESILEYQPDPPQGLALVEARDE 381
            .|.||||:.|:||||.:|||||:|..::::  |..|   ||:..|   || :|.:.|.|:.....
  Rat   289 SCLHEFHRTCVDPWLHQHRTCPLCMFNIVE--GDSFSQALGASPS---YQ-EPGRRLHLIRQHPG 347

  Fly   382 SAD--------LNRSRDFVVDF--PRVFVLDSGCVVGAREMLFP----CRIPERSQS---SLSLR 429
            .|.        |..||:.|...  ||.|:......:|:|....|    .|.||..|.   |....
  Rat   348 HAHYHLPSAYLLGPSRNSVAQTPRPRPFLPSQEPSMGSRHQRLPRASHLRAPEEQQHLAVSPGHP 412

  Fly   430 QARDW----------------VSLMSNKLEEQQGLRSMRNDEMQQQLLSARESARHRRSRSADGR 478
            .|:.|                |:|...:..|..|              |.......|....|||.
  Rat   413 YAQGWGPNRLRCTSQHPNACPVALRRARPHESSG--------------SGESYCTERSGYLADGP 463

  Fly   479 YSTGCFG---GRQRQPSVLVSSLGQPQLHSEVAQMQRSNSS--QALKHLTDAAHAQSRQRQRESF 538
            .|....|   |......|..:.:....:|...:..:.|.||  ..|.:.:.....|.::.|....
  Rat   464 ASDSSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCSPEGALQGKEVQPSMT 528

  Fly   539 DFARTRRRFMRRESDEISLRSLPRRGATS-AAHRQLHRER 577
            ...|             ||.|:...|.|. ::|...||.|
  Rat   529 SRPR-------------SLDSVVPTGETQVSSHIHYHRHR 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	24/132 (18%)
		UPF0233	226..>258	CDD:299753	6/42 (14%)
		zf-RING_2	301..344	CDD:290367	21/44 (48%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	22/140 (16%)
		RING-H2_RNF43	270..316	CDD:319712	22/45 (49%)
		dnaA	598..>743	CDD:237605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920