DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gol and RNF167

DIOPT Version :9

Sequence 1:	NP_001163300.1	Gene:	gol / 38006	FlyBaseID:	FBgn0004919	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens

Alignment Length:	339	Identity:	90/339 - (26%)
Similarity:	138/339 - (40%)	Gaps:	81/339 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 NMEFAQEQARYG-----EGKVLNVTGRLIHITATDNFSDDYACTPYIRGTLGAPIPDKGETWIAL 144
            :|:||...|.:|     ||    :.|.|:..      ..|.||:|.   ....|.|..|..:|||
Human    35 SMDFADLPALFGATLSQEG----LQGFLVEA------HPDNACSPI---APPPPAPVNGSVFIAL 86

  Fly   145 VRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVITYQN--IGQDLSLTL 207
            :||..|.|:.||.:..:......:::|   |...|.:.:...:..|...|...:  ||:..|
Human    87 LRRFDCNFDLKVLNAQKAGYGAAVVHN---VNSNELLNMVWNSEEIQQQIWIPSVFIGERSS--- 145

  Fly   208 DKGYNVTISIIEGRRGVRTISSLNRTSVL-FVSISFIVLMIISLVWLIFYYIQRFRYMQAKDQQS 271
              .|...:.:.|  :|.|.:...:.|..| :..|.|  ..|:.|:.|....:...|.:|.:.:..
Human   146 --EYLRALFVYE--KGARVLLVPDNTFPLGYYLIPF--TGIVGLLVLAMGAVMIARCIQHRKRLQ 204

  Fly   272 RNLCSVTKKAIMKIPT------------------------KTGKFSDEKDLDSDCCAICIEAYKP 312
            ||  .:||:.:.:|||                        .||...|:.|:    ||||::.|:.
Human   205 RN--RLTKEQLKQIPTHDYQKALNSSMFCPDLILPTCLISSTGFVGDQYDV----CAICLDEYED 263

  Fly   313 TDTIRILPCKHEFHKNCIDPWLIEHR-TCPMCKLDVLKFYGYVFLGSEESILEYQPDPPQGLALV 376
            .|.:|:|||.|.:|..|:||||.:.| |||:||..|.:..|.          |.|.:..||
Human   264 GDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGD----------EDQEEETQG---- 314

  Fly   377 EARDESADLNRSRD 390
               .|..|....||
Human   315 ---QEEGDEGEPRD 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	34/138 (25%)
		UPF0233	226..>258	CDD:299753	7/32 (22%)
		zf-RING_2	301..344	CDD:290367	21/43 (49%)
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	38/157 (24%)
		RING-H2_RNF167	252..297	CDD:319711	23/48 (48%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	21/40 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920