Protein Alignment gol and C18B12.4

DIOPT Version :10

• Sequence 1: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_510498.1
• Gene: C18B12.4 / 181600
• WormBaseID: WBGene00007666
• Length: 456
• Species: Caenorhabditis elegans
• Alignment Length: 486
• Identity: 100/486 - (20%)
• Similarity: 171/486 - (35%)
• Gaps: 149/486 - (30%)

  Fly    84 CNMEFAQEQAR---YGEGKVLNVTGRLIH--ITATDNFSDDYACTPYIRGTLGA-----PIPDKG 138
            ||.::..:..|   :||.:       |:|  :....||..|.:........||.     |:...|
 Worm    23 CNAQYVVDVMRMTSFGEEE-------LVHKCLAKGGNFGMDVSDFIISEENLGCGVGVEPVDACG 80

  Fly   139 ETWIALVRRGRC----------TFEEKVKHVYQ----QNAAG----VIIYN--DKQVMQLEKMQI 183
            ...||.....||          ......|..:|    ||:..    ||.||  .::.:.:|..::
 Worm    81 PVRIAQNHTTRCHNLFAFVSRSNISHPCKFSHQAFMVQNSTYPFRLVIFYNYPGQEPISMEGTEL 145

  Fly   184 KGKTRNIAAVITY---QNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVL 245
            :.|......:|::   :.|.:..|.|  .||.:.:.|..|               .:....:::.
 Worm   146 RDKVNIPVLMISHACKEEIAKKFSDT--AGYRLRVRIDPG---------------YYELFRYLIP 193

  Fly   246 MIISLVWLIFYYIQRFRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSDEKDLDSDCCAICIEAY 310
            .::.:|:....::.........:::..|...::|:.:.|||.|..:..|    |.|.||||:|::
 Worm   194 FLVVIVFCFALFLITLCVRGCVERRKLNKRRLSKRNLKKIPVKKYRLGD----DPDTCAICLESF 254

  Fly   311 KPTDTIRILPCKHEFHKNCIDPWLIEHR-TCPMCKLDVLKFYGYVFLGSEE-------------- 360
            ...:.:|.|||:|.||.||||.||.:.| .||:||..:         |::.
 Worm   255 ASGEKLRHLPCRHVFHCNCIDVWLTQTRKICPLCKRKI---------GTDSDSECSTNDLASTSQ 310

  Fly   361 -----SILEYQPDPPQGLALVEARDESADLNRSRDFVVDFPRVFVLDSGCVVGAREMLFPCRIPE 420
                 :.|....|...|..|...:.:..||..|::.:||...|.
 Worm   311 GPNDATALYNNADNQSGFELPVPQGQMVDLWSSQEALVDQDIVL--------------------- 354

  Fly   421 RSQSSLSLRQARDWVSLMSNKLEEQQGLRSMRNDEMQQQLLSARESARHRRSRSADGRYSTGCFG 485
               .:.:.|....:|         :...|.:||            |.|||     |....:|..|
 Worm   355 ---HNTTRRSITGFV---------RNAFRKLRN------------SPRHR-----DVDVHSGLEG 390

  Fly   486 G----RQRQPS-----VLVSSLGQPQLHSEV 507
            |    ||:..|     :|.:.:..|...||:
 Worm   391 GSYLVRQQTTSNDNDHLLENEVSDPTSSSEL 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	34/165 (21%)
		HRD1	<237..>347	CDD:227568	33/110 (30%)
		RING-H2_RNF130-like	302..347	CDD:438330	23/45 (51%)
C18B12.4	NP_510498.1	PA	<74..176	CDD:333703	22/103 (21%)
		HRD1	<223..>335	CDD:227568	36/124 (29%)
		RING-H2_RNF103	242..295	CDD:438136	27/65 (42%)