Protein Alignment gsb and PRRX2

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_057391.1
• Gene: PRRX2 / 51450
• HGNCID: 21338
• Length: 253
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 79/256 - (30%)
• Similarity: 103/256 - (40%)
• Gaps: 70/256 - (27%)

  Fly   135 VSSISRL-----LRGSSGSGTSHSIDGILGGGAGSVGSEDESEDDAEPS------VQLKRKQRRS 188
            |::..||     .|..:..|.:....|      ||.|||...:|...||      .:.|:||||:
Human    49 VAAAGRLAARPGARAEAREGAAREPSG------GSSGSEAAPQDGECPSPGRGSAAKRKKKQRRN 107

  Fly   189 RTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFA 253
            ||||::.|:.||||:|.||.|||.:.|||||:...|:||||||||.||||:.|:.
Human   108 RTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRN---------- 162

  Fly   254 PTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSVASMSPASSTSGTSSAAHSP 318
                                ..::.:|:|.....:|...||....||....|.|....|..|.||
Human   163 --------------------ERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSP 207

  Fly   319 VQTQAQQPGTGSEFMTSTYGVGSSNATYPSAAYSMPQTPATS-AEQLRSQFASAAASGSHH 378
            ..|            ...|..|||.          |.||..: |..:.|....|.....||
Human   208 YST------------VPPYSPGSSG----------PATPGVNMANSIASLRLKAKEFSLHH 246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	3/12 (25%)
		Homeodomain	186..242	CDD:459649	35/55 (64%)
PRRX2	NP_057391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..113		21/63 (33%)
		Homeodomain	109..161	CDD:459649	32/51 (63%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	230..243		2/12 (17%)