DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb and PAX7

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_002575.1	Gene:	PAX7 / 5081	HGNCID:	8621	Length:	520	Species:	Homo sapiens

Alignment Length:	476	Identity:	210/476 - (44%)
Similarity:	262/476 - (55%)	Gaps:	86/476 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILN 73
            |:|.:     |||||||||||||||||||||||.:|||||..|:||||||||||||||||||||.
Human    24 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 88

  Fly    74 RFQETGSIRPGVIGGSKPR-VATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPS--V 135
            |:|||||||||.||||||| |||||:|.:|||.|:..||:||||||.:|::.|.||:...||  |
Human    89 RYQETGSIRPGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLV 153

  Fly   136 SSISRLLRGSSG----------------SGTSHSIDGILGGGAGSVGSEDESED-DAEPSVQLKR 183
            |||||:||...|                ....||||||||.....:   ||..| ::||.:.|||
Human   154 SSISRVLRIKFGKKEEEDEADKKEDDGEKKAKHSIDGILGDKGNRL---DEGSDVESEPDLPLKR 215

  Fly   184 KQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQ 248
            |||||||||:.:|::.||:.|.||.|||:||||||||.|.||||||||||||||||.|||....|
Human   216 KQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQ 280

  Fly   249 ----------------VPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGG 297
                            :|:..|........|||:.  :.:.|.:::..|..|.|..::      |
Human   281 LAAFNHLLPGGFPPTGMPTLPPYQLPDSTYPTTTI--SQDGGSTVHRPQPLPPSTMHQ------G 337

  Fly   298 SVASMSPASSTSGTSSAAH--SPVQTQAQQPGTGSEFMT-----------STYGVGSSNATYPSA 349
            .:|:.:.|:.||....|.|  |........|...|..|.           |..|..|:....|.|
Human   338 GLAAAAAAADTSSAYGARHSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQA 402

  Fly   350 AYSMPQTP-------ATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPA-SAAG---NHIS 403
            .:|:  :|       |||.....||.|.:...|       ||...:.::.||. |..|   :.::
Human   403 DFSI--SPLHGGLDSATSISASCSQRADSIKPG-------DSLPTSQAYCPPTYSTTGYSVDPVA 458

  Fly   404 GYHH-QVDQKSSMMTTAPTYP 423
            ||.: |..|...::..|...|
Human   459 GYQYGQYGQSECLVPWASPVP 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	96/126 (76%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	42/56 (75%)
PAX7	NP_002575.1	paired box domain	34..164		98/129 (76%)
		PAX	34..163	CDD:238076	98/128 (77%)
		octapeptide	86..93		4/6 (67%)
		paired homeodomain	217..275		43/57 (75%)
		Homeobox	220..273	CDD:278475	39/52 (75%)
		Pax7	347..385	CDD:289156	8/37 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..409		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2843
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm8597
orthoMCL	1	0.900	-	-		OOG6_105365
Panther	1	1.100	-	-	LDO	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.820