Protein Alignment gsb and PAX6

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Alignment Length: 454
• Identity: 173/454 - (38%)
• Similarity: 232/454 - (51%)
• Gaps: 117/454 - (25%)

  Fly    19 GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRP 83
            |...||||||||:||||||:..|::|||:|.:|.|||.|||.|:||:|||||||.|:.|||||||
Human    85 GHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRP 149

  Fly    84 GVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLR----- 143
            ..|||||||||||::.|:|.:.|:..|.||:||||.:|:..|||...|.||||||:|:||
Human   150 RAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASE 214

  Fly   144 -----------------GSSGS---------GTS----HSIDGIL---GGG--AGSVGSEDESED 173
                             |.:||         |||    .:.||..   |||  ..|:.|..|..|
Human   215 KQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSD 279

  Fly   174 DAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRA 238
            :|:..:|||||.:|:||:|:.:||:|||:.|.||.||||:.||.||....|.|||:|||||||||
Human   280 EAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRA 344

  Fly   239 RLRKQ--LNTQQ-----VPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYG 296
            :.|::  |..|:     .||..|.|:|| :|......|.|...:|.::|
Human   345 KWRREEKLRNQRRQASNTPSHIPISSSF-STSVYQPIPQPTTPVSSFTS---------------- 392

  Fly   297 GSVASMSPASSTSGTSSAAHSPVQTQA----QQPGTGSEFMTSTYGVGSSNATYPSAAYSMPQTP 357
            ||:...:..:.|:..|:....|..|.|    .||...|:  ||:|            :..:|.:|
Human   393 GSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQ--TSSY------------SCMLPTSP 443

  Fly   358 ATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPASAAGNHISGYHHQVDQKSSMMTTAPT 421
            :.:..                  ::|:|.      ||           |.|....|..|.|:.|
Human   444 SVNGR------------------SYDTYT------PP-----------HMQTHMNSQPMGTSGT 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	78/123 (63%)
		Homeodomain	186..242	CDD:459649	33/55 (60%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	78/123 (63%)
		Homeodomain	293..348	CDD:459649	33/54 (61%)