Protein Alignment gsb and PAX5

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_057953.1
• Gene: PAX5 / 5079
• HGNCID: 8619
• Length: 391
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 146/418 - (34%)
• Similarity: 199/418 - (47%)
• Gaps: 94/418 - (22%)

  Fly    19 GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRP 83
            |.|.||||||||:||||||:.:|::|||:|..|||||.||||||||||||||||.|:.|||||:|
Human    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKP 80

  Fly    84 GVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRG---- 144
            ||||||||:||||.:..:|.|.|:..|.:|:||||.:|:...|||....||||||:|::|.
Human    81 GVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQ 145

  Fly   145 --------------SSGS------------GTSHSIDGILGGGAGSVGSEDESEDD--------- 174
                          |:||            |:|:||.||||..:.|..:.....|:
Human   146 PPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPN 210

  Fly   175 --AEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRR 237
              :.|.....|||.|. ..|:..|::.|:|:|.|..|.|::|..|..:....||       .:..
Human   211 GHSLPGRDFLRKQMRG-DLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTE-------YSAM 267

  Fly   238 ARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSVASM 302
            |.|...|:..:....:||....|     |:.|.|         ||:|              :.:.
Human   268 ASLAGGLDDMKANLASPTPADIG-----SSVPGP---------QSYP--------------IVTG 304

  Fly   303 SPASSTSGTSSAAHSPVQTQAQQPG-------TGSEFMTSTYGVGSSNATYPS--AAYSMPQTPA 358
            ...:||:......|.|...|.....       .||||..|.|    |:..|.|  .::..|....
Human   305 RDLASTTLPGYPPHVPPAGQGSYSAPTLTGMVPGSEFSGSPY----SHPQYSSYNDSWRFPNPGL 365

  Fly   359 TSAEQLRSQFASAAASGSHHPSTWDSYN 386
            ..:    ..:.||||.|:..|:...:|:
Human   366 LGS----PYYYSAAARGAAPPAAATAYD 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	81/123 (66%)
		Homeodomain	186..242	CDD:459649	15/55 (27%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/4 (50%)
		PAX	16..140	CDD:128645	81/123 (66%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		41/55 (75%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		21/47 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		7/35 (20%)
		Pax2_C	279..390	CDD:463563	31/147 (21%)