Protein Alignment gsb and PAX4

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_001353039.1
• Gene: PAX4 / 5078
• HGNCID: 8618
• Length: 351
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 119/280 - (42%)
• Similarity: 157/280 - (56%)
• Gaps: 25/280 - (8%)

  Fly    19 GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIRP 83
            |...:|||||:|:||||||...|:|||.:|.:|:|||.|||.|:||:|||||||.|:..||.:.|
Human     5 GISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEP 69

  Fly    84 GVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRG-SSG 147
            ..|||||||:|||.:.:||.:||...|.:|:|||:.:|...|:|.:...||||||:|:||. ...
Human    70 KGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQED 134

  Fly   148 SG---TSHSIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQY 209
            .|   |......:|.....:..|..|:.....|..     ..|:||.||..|.:|||:.|.|.||
Human   135 QGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGT-----GHRNRTIFSPSQAEALEKEFQRGQY 194

  Fly   210 PDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQ------------QVPSFAP----TSTS 258
            ||...|.:||.:|.|.|..|:||||||||:.|:|...:            .||..||    ...|
Human   195 PDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGLTVPRVAPGIISAQQS 259

  Fly   259 FGATPTTSAAPAPNMGMSLY 278
            .|:.||.:......:|.|.|
Human   260 PGSVPTAALPALEPLGPSCY 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	68/123 (55%)
		Homeodomain	186..242	CDD:459649	30/55 (55%)
PAX4	NP_001353039.1	PAX	5..129	CDD:128645	68/123 (55%)
		Homeodomain	172..227	CDD:459649	30/54 (56%)