DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb and PAX2

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_003981.3	Gene:	PAX2 / 5076	HGNCID:	8616	Length:	432	Species:	Homo sapiens

Alignment Length:	456	Identity:	149/456 - (32%)
Similarity:	205/456 - (44%)	Gaps:	119/456 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PYFGGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNR 74
            |:...:|  |.|.||||||||:||||||:.:|::|||:|..|||||.||||||||||||||||.|
Human     9 PFSAMHP--GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGR 71

  Fly    75 FQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSIS 139
            :.|||||:|||||||||:||||.:..:|.|.|:..|.:|:||||.:|:..|:||....||||||:
Human    72 YYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSIN 136

  Fly   140 RLLRGS---------SGSGT---------------------------SHSIDGILG--------- 159
            |::|..         .|:||                           |:||:||||
Human   137 RIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKR 201

  Fly   160 ---------------GGAG--------SVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALE 201
                           ||.|        .|........|::..|...||..|: .||:..|::||:
Human   202 KRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRA-DTFTQQQLEALD 265

  Fly   202 RIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTS 266
            |:|.|..||||:...|..:|                    :|.|...:|:..|....  ...:.|
Human   266 RVFERPSYPDVFQASEHIKS--------------------EQGNEYSLPALTPGLDE--VKSSLS 308

  Fly   267 AAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSVASMSPASSTSGTSSAAHSPVQTQAQQPGT--- 328
            |:..|.:|.::..:|::|              |.:....:||:......|.|...|...|.:
Human   309 ASTNPELGSNVSGTQTYP--------------VVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLA 359

  Fly   329 ----GSEFMTSTYGVGSSNA-----TYPSAAYSMPQTPATSAEQLRSQFASAAASGSHHPSTWDS 384
                ||||..:.|......|     .:.:.|..||...|.....|.....:.:..|.|.....||
Human   360 GMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLMPPPGAPPLPLLPLPMTATSYRGDHIKLQADS 424

  Fly   385 Y 385
            :
Human   425 F 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	81/123 (66%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	15/56 (27%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	81/123 (66%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		41/55 (75%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		21/47 (45%)
		homeodomain	255..>278	CDD:412151	12/22 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..325		5/20 (25%)
		Pax2_C	305..>390	CDD:403565	19/98 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810