Protein Alignment gsb and PAX1

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_006183.2
• Gene: PAX1 / 5075
• HGNCID: 8615
• Length: 534
• Species: Homo sapiens
• Alignment Length: 419
• Identity: 149/419 - (35%)
• Similarity: 187/419 - (44%)
• Gaps: 102/419 - (24%)

  Fly    18 QGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILNRFQETGSIR 82
            |..|.||||||||:|||||||.||.:|||:|..|:|||.||||||||||||||||.|:.|||||.
Human    97 QTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSIL 161

  Fly    83 PGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRGSSG 147
            ||.||||||||.||::...|.:.||..||||:||||.:|:..|||||.|.||||||||:||...|
Human   162 PGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIG 226

  Fly   148 SGTSHSIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDV 212
            |                         .|:|......||..|:.|...:.|         .|||
Human   227 S-------------------------LAQPGPYEASKQPPSQPTLPYNHI---------YQYP-- 255

  Fly   213 Y------TREELAQSTGL--TEARVQV---W--------------FSNRRARLRKQLNTQQVPSF 252
            |      |..::....|:  |...|.:   |              |..:...|.....|...|..
Human   256 YPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGTAYSPKM 320

  Fly   253 ----APTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAAYGGSV-ASMSPASSTSGTS 312
                ....|:|.|||..:....|.:...:..:||      ....:|.||.: |...|||:..|..
Human   321 EDWAGVNRTAFPATPAVNGLEKPALEADIKYTQS------ASTLSAVGGFLPACAYPASNQHGVY 379

  Fly   313 SA------AHSPVQTQAQ-----QPGTG--------SEFMT-------STYGVGSSNATYPSAAY 351
            ||      |..|....||     .||.|        :..||       .:....::....||.||
Human   380 SAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSREGSLPAPAARPRTPSVAY 444

  Fly   352 ----SMPQTPATSAEQLRSQFASAAASGS 376
                |.|:.|..|:.:.|::....|..|:
Human   445 TDCPSRPRPPRGSSPRTRARRERQADPGA 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	86/123 (70%)
		Homeodomain	186..242	CDD:459649	14/80 (18%)
PAX1	NP_006183.2	PAX	98..225	CDD:238076	88/126 (70%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	101..157		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	176..224		28/47 (60%)
		PHA03247	<212..517	CDD:223021	70/304 (23%)
		PRK07003	<402..>518	CDD:235906	16/72 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..480		11/50 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511