Protein Alignment gsb and OTX1

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 95/287 - (33%)
• Similarity: 134/287 - (46%)
• Gaps: 53/287 - (18%)

  Fly   161 GAGSVGSEDESEDDAEPSV---QLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQST 222
            |...:|....:.|...|||   ...|||||.||||:..|:|.||.:||:|:|||::.|||:|...
Human    11 GMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKI 75

  Fly   223 GLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSG 287
            .|.|:||||||.||||:.|:|   ||..|            .|.:.||......:..|....|||
Human    76 NLPESRVQVWFKNRRAKCRQQ---QQSGS------------GTKSRPAKKKSSPVRESSGSESSG 125

  Fly   288 AYENHAAYGGSVASMSPASSTSGTSSAA------HSPV--QTQAQQPGTGSEFMTSTYGVGSSNA 344
            .: ...|...|.:|.|.|||:|...:||      .:||  .:....|...|.:..::...||:
Human   126 QF-TPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSA-- 187

  Fly   345 TYPSAAYSMPQ---TPATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSF---FPPASAA---GN 400
               .|:.|:|:   .|:.::...||..|.||.:.:.:|.   ||...||:   :|..|::   |.
Human   188 ---PASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPM---SYGQGGSYGQGYPTPSSSYFGGV 246

  Fly   401 HISGY------HHQVDQKSSMMTTAPT 421
            ..|.|      ||...|.|.|   ||:
Human   247 DCSSYLAPMHSHHHPHQLSPM---APS 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645
		Homeodomain	186..242	CDD:459649	32/55 (58%)
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		20/70 (29%)
		TF_Otx	178..274	CDD:427350	28/104 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		7/17 (41%)