DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb and pax3

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	XP_012825755.1	Gene:	pax3 / 448464	XenbaseID:	XB-GENE-482740	Length:	486	Species:	Xenopus tropicalis

Alignment Length:	474	Identity:	208/474 - (43%)
Similarity:	266/474 - (56%)	Gaps:	85/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCVSKILN 73
            |:|.:     |||||||||||||||||||||||.:|||||..|:||||||||||||||||||||.
Frog    25 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 89

  Fly    74 RFQETGSIRPGVIGGSKPR-VATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSS 137
            |:|||||||||.||||||: |.||::|.:|||.|:..||:||||||.||::.||||:...|||||
Frog    90 RYQETGSIRPGAIGGSKPKQVTTPEVEKKIEEFKRDNPGMFSWEIRDKLLKDGVCDRNTVPSVSS 154

  Fly   138 ISRLLRGSSGSG------------------TSHSIDGILGGGA-GSVGSEDESEDDAEPSVQLKR 183
            |||:||...|.|                  ..|||||||...| .|..||:.|:.|:||.:.|||
Frog   155 ISRILRSKFGKGDEEDIELDRKEQEESEKRAKHSIDGILRERAPASPESEEGSDIDSEPDLPLKR 219

  Fly   184 KQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQ 248
            |||||||||:.:|::.|||.|.||.|||:||||||||...||||||||||||||||.|||....|
Frog   220 KQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQ 284

  Fly   249 -------------------VPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAA 294
                               :|::..:.||:..|....|...|:  .:::..|..|.|..:::
Frog   285 LMAFNHLIPGAFPPAAMPALPTYQLSETSYQPTSIPQAVSDPS--NTVHRPQPLPPSSVHQS--- 344

  Fly   295 YGGSVASMSPASSTS--------GTSSAAHSPV----QTQAQQPGTGSEFMTSTYGVGSSNATYP 347
               |:.| :|.||::        |.||...|.|    .:....|..|:.......|:.:::...|
Frog   345 ---SLPS-NPESSSAYCLPSGRHGFSSYTDSFVPPSGPSNPMNPAIGNGLSPQVMGLLTNHGGVP 405

  Fly   348 SAAYSMPQT-----PATSAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPASAAGNHISGYHH 407
                ..|||     |.|...:..:..:::.:....|..:.||.:.:.|:.||..:.    |||
Frog   406 ----HQPQTDYALSPLTGGLEPPTAVSASCSQRLEHMKSLDSLSTSQSYCPPTYST----SGY-- 460

  Fly   408 QVDQKSSMMTTAPTYPYFG 426
                 |....|...||.:|
Frog   461 -----SMEPVTGYQYPQYG 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	95/124 (77%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	42/56 (75%)
pax3	XP_012825755.1	PAX	35..162	CDD:238076	97/126 (77%)
		Homeobox	224..278	CDD:365835	39/53 (74%)
		Pax7	349..393	CDD:372070	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	211	1.000	Domainoid score	I2745
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm9489
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020