DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb and toy

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	181/523 - (34%)
Similarity:	251/523 - (47%)	Gaps:	132/523 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SALNMTPYFGGYPFQGQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVSHGCV 68
            |::..:..| |....|...:||||||::||||||:..|::|||:|.:|.|||.|||.|:||:|||
  Fly    15 SSVGQSTLF-GCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCV 78

  Fly    69 SKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAP 133
            ||||.|:.|||||:|..||||||||||..:..:|.:.|:..|.||:||||.:|:...||:..|.|
  Fly    79 SKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIP 143

  Fly   134 SVSSISRLLR-------------------------GSSG--------SGTSH------------- 152
            |||||:|:||                         |.:|        :.|:|
  Fly   144 SVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSP 208

  Fly   153 ---------------------------SIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRT 190
                                       |.|....|.:....|.||   |::..::||||.:|:||
  Fly   209 ANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDE---DSQMRLRLKRKLQRNRT 270

  Fly   191 TFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQ--LNTQQ----- 248
            :|||:|||:||:.|.||.||||:.||.||...||.|||:|||||||||:.|::  :.||:
  Fly   271 SFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADT 335

  Fly   249 VPSFAPTSTS---FGATPTTSAAPAPNMGMSLYSS----QSWPSSGAYEN---HAAYGGSVASMS 303
            |.....|||:   .|.|.::|.|.:.|....:.:|    ....||....|   .|:.|.:|  :.
  Fly   336 VDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNSAINVAERTSSALVSNSLPEASNGPTV--LG 398

  Fly   304 PASSTSGTSSAAHSPVQTQAQQPGTGSEFMTSTYGVGSSNATYPSAAYSMPQTPATSAEQLRSQF 368
            ..::|:.|||.: .|:|..|.:....|.|          |..|.    |:||..||.||...|..
  Fly   399 GEANTTHTSSES-PPLQPAAPRLPLNSGF----------NTMYS----SIPQPIATMAENYNSSL 448

  Fly   369 ASAAASGSHHPSTW---DSYNFAGSFFPPASAAGNHISGYH----------HQVDQKSSMMTTAP 420
                  ||..||..   |:|.:  .|..|.|....::|.:|          ||...:..:.|.:.
  Fly   449 ------GSMTPSCLQQRDAYPY--MFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSS 505

  Fly   421 TYP 423
            ..|
  Fly   506 PMP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	72/123 (59%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	37/56 (66%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	72/123 (59%)
		COG5576	<253..368	CDD:227863	54/117 (46%)
		Homeobox	269..322	CDD:395001	35/52 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910