DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb and eyg

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001014582.1	Gene:	eyg / 39419	FlyBaseID:	FBgn0000625	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	151/508 - (29%)
Similarity:	204/508 - (40%)	Gaps:	175/508 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SALNMTPYFGGYPFQGQGRVNQLGGVFINGRPLPNHIRRQ--IVEMAA-AGVRPCVISRQLRVSH 65
            :::.:.|.|||....| |..:..||.  .|..| |.:..|  ::|.:. .|:|...|::.:....
  Fly    84 TSVQIPPGFGGGGSTG-GIPHGAGGP--TGSTL-NTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQ 144

  Fly    66 GCVSKILNRFQETGSIR-PGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDK 129
            |.|||:|      ||:| ||:||||||:||||.:.|:||:.|:..|.||:||||.:||..|||..
  Fly   145 GAVSKLL------GSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTN 203

  Fly   130 QNAPSVSSISRLLRGSS------------------------GSGTSH---SIDG----------- 156
            ..|||||||:|:||..:                        ||.|.|   ::.|
  Fly   204 ATAPSVSSINRILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPS 268

  Fly   157 ---------------------------------ILGGGAGSV----------GSEDESE------ 172
                                             ::.||||..          ||.|..|
  Fly   269 ALWSVAAPTLANLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESADENR 333

  Fly   173 --------DDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARV 229
                    ||.||      |.||:|||||.:|::.||:.|.::.||.|.|||.|:..|.|:||||
  Fly   334 HIDSDYLDDDDEP------KFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARV 392

  Fly   230 QVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSWPSSGAYENHAA 294
            |||||||||:.|:    .|..:......|..|.|             |:|.||        |.|
  Fly   393 QVWFSNRRAKWRR----HQRMNLLKRQRSSPANP-------------LHSQQS--------NDA- 431

  Fly   295 YGGSVASMSPASSTSGTSSAAHSPVQTQAQQPGTGSEFMTSTYGVGSSNATYPSAAYSMPQTPAT 359
               ..:|.:|::.:|.::||..:|| ...|||                   .|......||.|..
  Fly   432 ---PASSPTPSNHSSASTSAPVAPV-PPPQQP-------------------LPLCGDHSPQGPPP 473

  Fly   360 SAEQLRSQFASAAASGSHHPSTWDSYNFAGSFFPPASAAGNHISGYHHQVDQK 412
            |. .|............|||          ...|...||...:|.||.|..|:
  Fly   474 SV-LLHPLHGPPGGHHHHHP----------LHLPTHPAALQLLSHYHQQQQQQ 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	56/127 (44%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	34/56 (61%)
eyg	NP_001014582.1	HTH	120..217	CDD:304362	48/102 (47%)
eyg	NP_001014582.1	Homeobox	352..404	CDD:278475	31/51 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450812
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840