DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gsb and Vsx2

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	90/373 - (24%)
Similarity:	140/373 - (37%)	Gaps:	106/373 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 QNAPSVSSISRLLRGSSGSGT---------SHSIDGILGGGAGSVGSEDESEDDAEPSVQLKRKQ 185
            |..|.:.|.      ::|:||         ...::.:.|.|.|             |:.:.|:|:
  Fly   184 QGFPQLKSF------AAGAGTCLPGSLAPKDFGMESLNGFGVG-------------PNSKKKKKK 229

  Fly   186 RR-SRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQLNTQQV 249
            || |||.|::.|::.||..|....|||||.||.|:..|.|.|.|:||||.||||:.||   |::|
  Fly   230 RRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRK---TEKV 291

  Fly   250 PSFAPTSTSFG--ATPTTSAAPAPN----------------MGM--------SLYSSQSWPSSGA 288
            ...:.....:|  ......:.|.|:                :||        |:.:..:......
  Fly   292 WGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDSG 356

  Fly   289 YENHAAYGGSVAS----------------------MSPASSTSGTSSAAHSPVQTQAQQPGTGSE 331
            ..:|....||.::                      :|||.|:..||::..:|..:.:...|..|.
  Fly   357 VSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPAPSSCPTSASTSAPPTSTSGYAGAASS 421

  Fly   332 FMTSTYGVGSSN-ATYPSAAYSMPQTPATSAEQLRSQ---------FASAAASG----SHHPSTW 382
            ..|:..|..::| ::.|......|........||:.|         .|.|..:|    |:|| ..
  Fly   422 AATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQASLYLGAGAVVTGCAPPSYHP-LL 485

  Fly   383 DSYNFAGS-----------FFPPASAAGNHISGYHHQVDQKSSMMTTA 419
            |:.|.||:           ....|.||....:...||..|:.....||
  Fly   486 DAANAAGAGAAASSKDFHMIMNTAVAAAAAAAQQQHQQQQQQQQQATA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	3/12 (25%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	31/57 (54%)
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	28/52 (54%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450955
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840