Protein Alignment gsb and Pitx2

DIOPT Version :10

• Sequence 1: NP_523863.1
• Gene: gsb / 38005
• FlyBaseID: FBgn0001148
• Length: 427
• Species: Drosophila melanogaster
• Sequence 2: NP_001035967.1
• Gene: Pitx2 / 18741
• MGIID: 109340
• Length: 324
• Species: Mus musculus
• Alignment Length: 349
• Identity: 96/349 - (27%)
• Similarity: 137/349 - (39%)
• Gaps: 75/349 - (21%)

  Fly    89 SKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDKQNAPSVSSISRLLRGSSGSGTSHS 153
            |.|....|...:....|...||.  |.:.....:|.......::|.|:...   :|..|...
Mouse    23 SSPFCHHPQALAMASVLAPGQPR--SLDSSKHRLEVHTISDTSSPEVAEKD---KGQQGKNE--- 79

  Fly   154 IDGILGGGAGSVGSEDESEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREEL 218
                      .||:||.|:         |::|||.||.|::.|:..||..|.|.:|||:.||||:
Mouse    80 ----------DVGAEDPSK---------KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEI 125

  Fly   219 AQSTGLTEARVQVWFSNRRARLRKQLNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLYSSQSW 283
            |..|.||||||:|||.||||:.||:...||...   ....||        |..|..|..|... :
Mouse   126 AVWTNLTEARVRVWFKNRRAKWRKRERNQQAEL---CKNGFG--------PQFNGLMQPYDDM-Y 178

  Fly   284 PSSGAYENHAAYGGSVASM----------------------SPASSTSGTSSAAHSPVQTQAQQP 326
            |.. :|.|.||.|.:.||:                      ||.:|.|..|.::..........|
Mouse   179 PGY-SYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVP 242

  Fly   327 GTGSEFMTSTYGVGSS--NATYPSAA--YSMPQTPATSAEQLRSQFASAAASGSHHPSTWDSYNF 387
            |:....:.:...:.|.  |:..|:.|  |:.|..|....:...|..||.......|    .|:.:
Mouse   243 GSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQH----SSFGY 303

  Fly   388 AGSFFPPASAAGNHISGYHHQVDQ 411
            | |...|||    ::|...:.||:
Mouse   304 A-SVQNPAS----NLSACQYAVDR 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	10/53 (19%)
		Homeodomain	186..242	CDD:459649	32/55 (58%)
Pitx2	NP_001035967.1	Homeodomain	93..149	CDD:459649	32/55 (58%)
		OAR	282..299	CDD:461067	4/20 (20%)