DRSC/TRiP Functional Genomics Resources

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Protein Alignment gsb and DUX4

DIOPT Version :10

Sequence 1:NP_523863.1 Gene:gsb / 38005 FlyBaseID:FBgn0001148 Length:427 Species:Drosophila melanogaster
Sequence 2:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens


Alignment Length:279 Identity:70/279 - (25%)
Similarity:94/279 - (33%) Gaps:86/279 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 RRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSNRRARLRKQ------- 243
            ||.||..:..|...|.|.|.:.::|.:..|||||:.|||.|:|:|:||.|||||...|       
Human    95 RRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQ 159

  Fly   244 ------------------------------LNTQQVPSFAPTSTSFGATPTTSAAPAPNMGMSLY 278
                                          |....||. ||.:...||..:.:|..||    :|.
Human   160 AGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPC-APGALPQGAFVSQAARAAP----ALQ 219

  Fly   279 SSQSWPSSGAYENHAAYGGSVASMSPASSTSGTSS------------------------------ 313
            .||:.|:.| ....|...|..|..:||......|.                              
Human   220 PSQAAPAEG-ISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSREDRDPQRDGLPGPCAV 283

  Fly   314 AAHSPVQTQAQQPGT-------GSEFMTSTYGVGSSNATY-PSAAYSMPQTPA-----TSAEQLR 365
            |...|.|...|..|.       ||.:.....|...:.|.: |.|..:.|..||     .||.|.:
Human   284 AQPGPAQAGPQGQGVLAPPTSQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQ 348

  Fly   366 SQFASAAASGSHHPSTWDS 384
            .|...|.:.....|:.|.:
Human   349 MQGIPAPSQALQEPAPWSA 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gsbNP_523863.1 PAX 19..143 CDD:128645
Homeodomain 186..242 CDD:459649 27/55 (49%)
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 4/6 (67%)
Homeodomain 95..149 CDD:459649 26/53 (49%)
PRK07764 <141..319 CDD:236090 37/183 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 30/144 (21%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 11/41 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Blue background indicates that the domain is not in the aligned region.

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