DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gsb and pax3b

DIOPT Version :9

Sequence 1:	NP_523863.1	Gene:	gsb / 38005	FlyBaseID:	FBgn0001148	Length:	427	Species:	Drosophila melanogaster
Sequence 2:	NP_001315326.1	Gene:	pax3b / 100150137	ZFINID:	ZDB-GENE-080917-53	Length:	469	Species:	Danio rerio

Alignment Length:	433	Identity:	197/433 - (45%)
Similarity:	259/433 - (59%)	Gaps:	57/433 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NMTPYF--GGYPFQ-----GQGRVNQLGGVFINGRPLPNHIRRQIVEMAAAGVRPCVISRQLRVS 64
            :::|.:  .|:|.:     |||||||||||||||||||||||.:|||||..|:||||||||||||
Zfish    15 SLSPNYPRSGFPMEVSTPMGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVS 79

  Fly    65 HGCVSKILNRFQETGSIRPGVIGGSKPRVATPDIESRIEELKQSQPGIFSWEIRAKLIEAGVCDK 129
            ||||||||.|:|||||||||.|||:|.:..:||:|.|:||.|:..|||||||||.||::.|:||:
Zfish    80 HGCVSKILCRYQETGSIRPGAIGGTKSKTTSPDVEKRVEEYKRENPGIFSWEIRDKLLKEGICDR 144

  Fly   130 QNAPSVSSISRLLRGSSGSGT------------------------SHSIDGILGGGAGSVGSEDE 170
            .|.|:||||||::||.||:..                        :|||:|||..  .|..|::.
Zfish   145 NNVPTVSSISRIMRGRSGTRADEEEEEEDEEDIERREREENAHRGAHSIEGILAD--RSSPSDEG 207

  Fly   171 SEDDAEPSVQLKRKQRRSRTTFSNDQIDALERIFARTQYPDVYTREELAQSTGLTEARVQVWFSN 235
            ||.::||.:.||||||||||||:.||::.|||.|.||.|||:||||||||...||||||||||||
Zfish   208 SEVESEPDLPLKRKQRRSRTTFTADQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSN 272

  Fly   236 RRARLRKQLNTQQVPSF-----------APTSTS---FGATPTTSAAPAPNMGMSLYSSQSWPSS 286
            ||||.|||....|:.:|           |.:|.|   ...:|...||...:.| :::..|..|.|
Zfish   273 RRARWRKQAGANQLMAFNHLIPGGFSHHAMSSLSPYQLSESPYPPAALPQDSG-TVHRPQPLPHS 336

  Fly   287 GAYENHAA--YGGSVASMSPASSTSGTSSA--AHSPVQTQAQQPGTGSEFMTSTYGVGSSNATYP 347
            ....:..|  .||:...:|.....:|.|.|  .|:.....|...|..|:.|......|:|:.|
Zfish   337 SHQSSGGAGPEGGASYCLSSRHGYTGYSDAFGPHNTHNNNAINNGLSSQVMGLITPSGASHPT-- 399

  Fly   348 SAAYSMPQTPATS---AEQLRSQFASAAASGSHHPSTWDSYNF 387
            .|.:|:....:.|   ::::.|..:..|.|...:|.::.|.:|
Zfish   400 QAEFSLDSGSSVSSSCSQRMESLSSLPALSNLSNPQSYSSASF 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb	NP_523863.1	PAX	19..143	CDD:128645	92/123 (75%)
gsb	NP_523863.1	homeodomain	186..243	CDD:238039	43/56 (77%)
pax3b	NP_001315326.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2805
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.880