DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gsb-n and PAX7

DIOPT Version :9

Sequence 1:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_002575.1	Gene:	PAX7 / 5081	HGNCID:	8621	Length:	520	Species:	Homo sapiens

Alignment Length:	452	Identity:	210/452 - (46%)
Similarity:	259/452 - (57%)	Gaps:	87/452 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILN 74
            |:|.:     |||||||||||||||||||||||.||||||..|:||||||||||||||||||||.
Human    24 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 88

  Fly    75 RYQETGSIRPGVIGGSKPK-VTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD---PPS--T 133
            |||||||||||.||||||: |.:|::|.:|:|.::|||.:||||||::|:|:|..|   .||  .
Human    89 RYQETGSIRPGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPSGLV 153

  Fly   134 SSISRLLR----------GSDRGSEDGRK--DYTINGILGGRDSDI---SDTESEPGIPLKRKQR 183
            |||||:||          .:|:..:||.|  .::|:||||.:.:.:   ||.||||.:|||||||
Human   154 SSISRVLRIKFGKKEEEDEADKKEDDGEKKAKHSIDGILGDKGNRLDEGSDVESEPDLPLKRKQR 218

  Fly   184 RSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGL 248
            ||||||||||||.||:||.||.|||:||||||||.|.|||||:||||||||||.||.:|.:.  |
Human   219 RSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQ--L 281

  Fly   249 SPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMAGYSPAPGTTATGAGMNDG---VHHAAH-APS 309
            :..|.              ..|.|:.|.|:.::..|.....|..|.....||   ||.... .||
Human   282 AAFNH--------------LLPGGFPPTGMPTLPPYQLPDSTYPTTTISQDGGSTVHRPQPLPPS 332

  Fly   310 SHHSAATAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQPGHFGSQNYYHQDYSKLTIDDFSKLTA 374
            :.|....|||||...|. ..|     .|:|.|                 ..||    |.|
Human   333 TMHQGGLAAAAAAADTS-SAY-----GARHSF-----------------SSYS----DSF----- 365

  Fly   375 DSVSKISPSLHLSDNYSKLEAPSNWSQAAYHAAANYNAHVAQHQLNDYAAAAAHGNPASAYS 436
              ::..:||.|::      ...:..|........|.:|...|.|. |::.:..||...||.|
Human   366 --MNPAAPSNHMN------PVSNGLSPQVMSILGNPSAVPPQPQA-DFSISPLHGGLDSATS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	92/126 (73%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	44/52 (85%)
PAX7	NP_002575.1	paired box domain	34..164		94/129 (73%)
		PAX	34..163	CDD:238076	94/128 (73%)
		octapeptide	86..93		5/6 (83%)
		paired homeodomain	217..275		48/57 (84%)
		Homeobox	220..273	CDD:278475	44/52 (85%)
		Pax7	347..385	CDD:289156	13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..409		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm8597
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4594
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.950