DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gsb-n and PAX5

DIOPT Version :9

Sequence 1:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	398	Identity:	151/398 - (37%)
Similarity:	194/398 - (48%)	Gaps:	101/398 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRP 84
            |.|.||||||||:||||||:.:|.:|||:|..|||||.||||||||||||||||.||.|||||:|
Human    16 GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKP 80

  Fly    85 GVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSSISRLLRG---- 142
            ||||||||||.:|::..:|.|.:::||::|:||||::|:.|...|   .||.|||:|::|.
Human    81 GVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQ 145

  Fly   143 ----------------------SDRGSEDGRKDYTINGILG-----------GRDSDISDT---- 170
                                  |...::.....|:|:||||           .||..|.::
Human   146 PPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPN 210

  Fly   171 -ESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTE----ARIQVWF 230
             .|.||....|||.|. ..||.:|||.|:|.|.|..|.|::|..|..:....||    |.:....
Human   211 GHSLPGRDFLRKQMRG-DLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGL 274

  Fly   231 SNRRARLRKHSGGSNSGLSPMNSGSSNVG-------VGVGLSGATAPLGY----GPLGVGSMAGY 284
            .:.:|.|        :..:|.:.|||..|       .|..|:..|.| ||    .|.|.||   |
Human   275 DDMKANL--------ASPTPADIGSSVPGPQSYPIVTGRDLASTTLP-GYPPHVPPAGQGS---Y 327

  Fly   285 SPAPGTTATGAGMNDGVHHAAHAPSSHHSAATAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQPG 349
            | ||  |.||.           .|.|..|     .:.:.|.|...|:     ....||    .||
Human   328 S-AP--TLTGM-----------VPGSEFS-----GSPYSHPQYSSYN-----DSWRFP----NPG 364

  Fly   350 HFGSQNYY 357
            ..||..||
Human   365 LLGSPYYY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	79/123 (64%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	17/56 (30%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		2/4 (50%)
		PAX	16..140	CDD:128645	79/123 (64%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		19/47 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		10/35 (29%)
		Pax2_C	279..389	CDD:403565	38/134 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810