Protein Alignment gsb-n and PAX2

DIOPT Version :10

• Sequence 1: NP_523862.1
• Gene: gsb-n / 38004
• FlyBaseID: FBgn0001147
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_003981.3
• Gene: PAX2 / 5076
• HGNCID: 8616
• Length: 432
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 150/401 - (37%)
• Similarity: 197/401 - (49%)
• Gaps: 117/401 - (29%)

  Fly     1 MDMSSANSLRPLFAGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVS 65
            |||..  ...|..|.:|  |.|.||||||||:||||||:.:|.:|||:|..|||||.||||||||
Human     1 MDMHC--KADPFSAMHP--GHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVS 61

  Fly    66 HGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD- 129
            ||||||||.||.|||||:|||||||||||.:|::..:|.|.:::||::|:||||::|:.||..|
Human    62 HGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDN 126

  Fly   130 --PPSTSSISRLLR------------GSDRG--------------------SEDGRKDYTINGIL 160
              .||.|||:|::|            |:..|                    |.|....|:|||||
Human   127 DTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGIL 191

  Fly   161 G---------GRDS-----------------------DISD-----TESEPGIPLKRKQRRSRTT 188
            |         .||.                       |:|:     .:|:.|:...||..|: .|
Human   192 GIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRA-DT 255

  Fly   189 FTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSNS------G 247
            ||.:|||||:|.|.|..||||:...|                     .::...|...|      |
Human   256 FTQQQLEALDRVFERPSYPDVFQASE---------------------HIKSEQGNEYSLPALTPG 299

  Fly   248 LSPMN---SGSSNVGVGVGLSGA-TAPLGYG-PLGVGSMAGYSP-APGT------TATGAGMNDG 300
            |..:.   |.|:|..:|..:||. |.|:..| .:...::.||.| .|.|      |:|.|||..|
Human   300 LDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPG 364

  Fly   301 VHHAAHAPSSH 311
            ...:.: |.||
Human   365 SEFSGN-PYSH 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	HTH_CRP	20..141	CDD:481199	80/123 (65%)
		Homeodomain	183..239	CDD:459649	17/55 (31%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	80/123 (65%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		20/47 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		6/20 (30%)
		Pax2_C	305..>390	CDD:463563	23/71 (32%)