Protein Alignment gsb-n and PAX1

DIOPT Version :10

• Sequence 1: NP_523862.1
• Gene: gsb-n / 38004
• FlyBaseID: FBgn0001147
• Length: 449
• Species: Drosophila melanogaster
• Sequence 2: NP_006183.2
• Gene: PAX1 / 5075
• HGNCID: 8615
• Length: 534
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 159/512 - (31%)
• Similarity: 212/512 - (41%)
• Gaps: 165/512 - (32%)

  Fly    19 QGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIR 83
            |..|.||||||||:|||||||.|||:|||:|..|:|||.||||||||||||||||.||.|||||.
Human    97 QTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSIL 161

  Fly    84 PGVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFADP---PSTSSISRLLRGSDR 145
            ||.||||||:||:|.:...|.:.::.:|.||:||||::|:.:|..|.   ||.|||||:||..
Human   162 PGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNK-- 224

  Fly   146 GSEDGRKDYTINGILGGRDSDISDTESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVY 210
                          :|        :.::||.....||..|:.|.....:         .|||
Human   225 --------------IG--------SLAQPGPYEASKQPPSQPTLPYNHI---------YQYP--- 255

  Fly   211 TREELAQTTALTEARIQVWFSNRRARLRKHSGGSNSGLSPMNSGSSNVGVGVGLSGATAPLGYGP 275
                .....:.|.|::                ||:.|: |..:|.    |.:..|..:|......
Human   256 ----YPSPVSPTGAKM----------------GSHPGV-PGTAGH----VSIPRSWPSAHSVSNI 295

  Fly   276 LGV-------GSMAG-----YSPAPGTTATGAGMND--GVHHAAH--APSSHHSAATAAAAAHHH 324
            ||:       |::||     |||.         |.|  ||:..|.  .|:.:.....|..|...:
Human   296 LGIRTFMEQTGALAGSEGTAYSPK---------MEDWAGVNRTAFPATPAVNGLEKPALEADIKY 351

  Fly   325 TQ-------MGGY---DLVQSAAQHGF---PGG----------------FAQPG-----HFG--- 352
            ||       :||:   ....::.|||.   |||                .|.||     |.|
Human   352 TQSASTLSAVGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELA 416

  Fly   353 -SQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLSDNYSKLEAP---SNWSQAAYHAAANYNAH 413
             :..:.|....       ..|.|.:....:||:..:|..|:...|   |..::|.....|:..|.
Human   417 AAMTFKHPSRE-------GSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQ 474

  Fly   414 VAQHQLNDYAAAAAHG-------------------NPASAYSHPL--PTQGQAKYWS 449
            |.       |||.|.|                   .|||..:.|.  |......|||
Human   475 VC-------AAAPAIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWS 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	HTH_CRP	20..141	CDD:481199	79/123 (64%)
		Homeodomain	183..239	CDD:459649	7/55 (13%)
PAX1	NP_006183.2	PAX	98..225	CDD:238076	81/142 (57%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	101..157		44/55 (80%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	176..224		20/47 (43%)
		PHA03247	<212..517	CDD:223021	83/388 (21%)
		PRK07003	<402..>518	CDD:235906	28/129 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..480		14/69 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511		3/18 (17%)