DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gsb-n and pax3

DIOPT Version :9

Sequence 1:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	XP_012825755.1	Gene:	pax3 / 448464	XenbaseID:	XB-GENE-482740	Length:	486	Species:	Xenopus tropicalis

Alignment Length:	483	Identity:	216/483 - (44%)
Similarity:	259/483 - (53%)	Gaps:	97/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GYPFQ-----GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILN 74
            |:|.:     |||||||||||||||||||||||.||||||..|:||||||||||||||||||||.
Frog    25 GFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILC 89

  Fly    75 RYQETGSIRPGVIGGSKPK-VTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD---PPSTSS 135
            |||||||||||.||||||| ||:||:|.:|:|.:::||.:||||||:||:|:|..|   .||.||
Frog    90 RYQETGSIRPGAIGGSKPKQVTTPEVEKKIEEFKRDNPGMFSWEIRDKLLKDGVCDRNTVPSVSS 154

  Fly   136 ISRLLR-----GSDRGSEDGRKD---------YTINGILGGR------DSDISDTESEPGIPLKR 180
            |||:||     |.:...|..||:         ::|:|||..|      ..:.||.:|||.:||||
Frog   155 ISRILRSKFGKGDEEDIELDRKEQEESEKRAKHSIDGILRERAPASPESEEGSDIDSEPDLPLKR 219

  Fly   181 KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSGGSN 245
            |||||||||||||||.|||||.||.|||:||||||||...|||||:||||||||||.||.:|.:.
Frog   220 KQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQ 284

  Fly   246 SGLSPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMA--GYSPAPGTTATGAGMNDGVHHAAH-A 307
              |...|.         .:.||..|.....|....::  .|.|.....|.....|. ||.... .
Frog   285 --LMAFNH---------LIPGAFPPAAMPALPTYQLSETSYQPTSIPQAVSDPSNT-VHRPQPLP 337

  Fly   308 PSSHHSAATAAAAAHHHTQMGGYDLVQSAAQHGF---------PGGFAQP--------------- 348
            |||.|.::..:    :......|.|  .:.:|||         |.|.:.|
Frog   338 PSSVHQSSLPS----NPESSSAYCL--PSGRHGFSSYTDSFVPPSGPSNPMNPAIGNGLSPQVMG 396

  Fly   349 ---GHFGSQNYYHQDY--SKLTIDDFSKLTADSVS--------KISPSLHLSDNYSKLEAPSNWS 400
               .|.|..:....||  |.|| ......||.|.|        |...||..|.:|    .|..:|
Frog   397 LLTNHGGVPHQPQTDYALSPLT-GGLEPPTAVSASCSQRLEHMKSLDSLSTSQSY----CPPTYS 456

  Fly   401 QAAYHAAANYNAHVAQHQLNDYAAAAAH 428
            .:.|....     |..:|...|..:|.|
Frog   457 TSGYSMEP-----VTGYQYPQYGQSAFH 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	95/124 (77%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	44/52 (85%)
pax3	XP_012825755.1	PAX	35..162	CDD:238076	97/126 (77%)
		Homeobox	224..278	CDD:365835	44/53 (83%)
		Pax7	349..393	CDD:372070	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	333	1.000	Inparanoid score	I2376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm9489
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4594
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.100