DRSC/TRiP Functional Genomics Resources

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Protein Alignment gsb-n and DUX4

DIOPT Version :10

Sequence 1:NP_523862.1 Gene:gsb-n / 38004 FlyBaseID:FBgn0001147 Length:449 Species:Drosophila melanogaster
Sequence 2:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens


Alignment Length:328 Identity:88/328 - (26%)
Similarity:116/328 - (35%) Gaps:91/328 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 ESEPGIPLKR---KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSN 232
            ||.|. |.:|   :.||.||..|..|...|.|||.:.::|.:..|||||:.|.|.|:|||:||.|
Human    81 ESRPW-PGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQN 144

  Fly   233 RRARLRKHSGGSNSGLSPMNSGS------------------SNVGV-GVGLSGATAPLGYGPLGV 278
            ||||   |.|  ..|.:|..:|.                  ::.|. |.||.....|...|.|..
Human   145 RRAR---HPG--QGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQ 204

  Fly   279 GSMAGYS--PAPGTTATGAGMNDGVHHAAHAPSSHHSAATA---AAAAH-------HHTQMGGYD 331
            |:....:  .||....:.|...:|:...|.|......||.|   .|.:|       .|......|
Human   205 GAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSRED 269

  Fly   332 LVQSAAQHGFPG--GFAQPG--HFGSQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLSDNYSK 392
              :...:.|.||  ..||||  ..|.|.              ..:.|...|:.||..        
Human   270 --RDPQRDGLPGPCAVAQPGPAQAGPQG--------------QGVLAPPTSQGSPWW-------- 310

  Fly   393 LEAPSNWSQAAYHAAANYN-----AHVAQHQLNDYAAAAAHGN------PASAYSHPLPTQGQAK 446
                 .|.:....|.|.:.     |...|....|.:|:|..|.      |:.|...|.|      
Human   311 -----GWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAP------ 364

  Fly   447 YWS 449
             ||
Human   365 -WS 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gsb-nNP_523862.1 HTH_CRP 20..141 CDD:481199
Homeodomain 183..239 CDD:459649 29/55 (53%)
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 9/21 (43%)
Homeodomain 95..149 CDD:459649 29/56 (52%)
PRK07764 <141..319 CDD:236090 47/211 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 35/172 (20%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 12/47 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Blue background indicates that the domain is not in the aligned region.

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