DRSC/TRiP Functional Genomics Resources

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Protein Alignment gsb-n and DUX4

DIOPT Version :9

Sequence 1:NP_523862.1 Gene:gsb-n / 38004 FlyBaseID:FBgn0001147 Length:449 Species:Drosophila melanogaster
Sequence 2:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens


Alignment Length:328 Identity:88/328 - (26%)
Similarity:116/328 - (35%) Gaps:91/328 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 ESEPGIPLKR---KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSN 232
            ||.|. |.:|   :.||.||..|..|...|.|||.:.::|.:..|||||:.|.|.|:|||:||.|
Human    81 ESRPW-PGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQN 144

  Fly   233 RRARLRKHSGGSNSGLSPMNSGS------------------SNVGV-GVGLSGATAPLGYGPLGV 278
            ||||   |.|  ..|.:|..:|.                  ::.|. |.||.....|...|.|..
Human   145 RRAR---HPG--QGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQ 204

  Fly   279 GSMAGYS--PAPGTTATGAGMNDGVHHAAHAPSSHHSAATA---AAAAH-------HHTQMGGYD 331
            |:....:  .||....:.|...:|:...|.|......||.|   .|.:|       .|......|
Human   205 GAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSRED 269

  Fly   332 LVQSAAQHGFPG--GFAQPG--HFGSQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLSDNYSK 392
              :...:.|.||  ..||||  ..|.|.              ..:.|...|:.||..        
Human   270 --RDPQRDGLPGPCAVAQPGPAQAGPQG--------------QGVLAPPTSQGSPWW-------- 310

  Fly   393 LEAPSNWSQAAYHAAANYN-----AHVAQHQLNDYAAAAAHGN------PASAYSHPLPTQGQAK 446
                 .|.:....|.|.:.     |...|....|.:|:|..|.      |:.|...|.|      
Human   311 -----GWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAP------ 364

  Fly   447 YWS 449
             ||
Human   365 -WS 366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
gsb-nNP_523862.1 PAX 20..141 CDD:278709
Homeobox 185..238 CDD:278475 27/52 (52%)
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
Homeobox 27..74 CDD:306543
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 9/21 (43%)
Homeobox 97..149 CDD:306543 27/54 (50%)
DNA_pol3_gamma3 <141..319 CDD:331207 47/211 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 35/172 (20%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 12/47 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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