DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gsb-n and pax3b

DIOPT Version :9

Sequence 1:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster
Sequence 2:	NP_001315326.1	Gene:	pax3b / 100150137	ZFINID:	ZDB-GENE-080917-53	Length:	469	Species:	Danio rerio

Alignment Length:	479	Identity:	208/479 - (43%)
Similarity:	267/479 - (55%)	Gaps:	89/479 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLRPLF--AGYPFQ-----GQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVS 65
            ||.|.:  :|:|.:     |||||||||||||||||||||||.||||||..|:||||||||||||
Zfish    15 SLSPNYPRSGFPMEVSTPMGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVS 79

  Fly    66 HGCVSKILNRYQETGSIRPGVIGGSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFAD- 129
            ||||||||.|||||||||||.|||:|.|.|||::|.|::|.::|||.|||||||:||:|||..|
Zfish    80 HGCVSKILCRYQETGSIRPGAIGGTKSKTTSPDVEKRVEEYKRENPGIFSWEIRDKLLKEGICDR 144

  Fly   130 --PPSTSSISRLLRG------SDRGSEDGRKD--------------YTINGILGGRDS---DISD 169
              .|:.|||||::||      .:...|:..:|              ::|.|||..|.|   :.|:
Zfish   145 NNVPTVSSISRIMRGRSGTRADEEEEEEDEEDIERREREENAHRGAHSIEGILADRSSPSDEGSE 209

  Fly   170 TESEPGIPLKRKQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRR 234
            .||||.:|||||||||||||||:|||.|||||.||.|||:||||||||...|||||:||||||||
Zfish   210 VESEPDLPLKRKQRRSRTTFTADQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRR 274

  Fly   235 ARLRKHSGGSNSGLSPMNSGSSNVGVGVGLSGATAPLGYGPLGVGSMAGY--SPAPGTTATGAGM 297
            ||.||.:|.:.  |...|.              ..|.|:....:.|::.|  |.:|...|.....
Zfish   275 ARWRKQAGANQ--LMAFNH--------------LIPGGFSHHAMSSLSPYQLSESPYPPAALPQD 323

  Fly   298 NDGVHHAAHAPSSHHSAATAAAAAHHHTQMGGYDLVQSAAQHGFPGGFAQPGHFGSQNYY----- 357
            :..||.....|.|.|.::..|...      ||.....| ::||:.|   ....||..|.:
Zfish   324 SGTVHRPQPLPHSSHQSSGGAGPE------GGASYCLS-SRHGYTG---YSDAFGPHNTHNNNAI 378

  Fly   358 ------------------HQDYSKLTIDDFSKLTADSVSKISPSLHLSDNYSKLEAPSNWSQAAY 404
                              |...::.::|..|.::: |.|:...||......|.|..|.::|.|::
Zfish   379 NNGLSSQVMGLITPSGASHPTQAEFSLDSGSSVSS-SCSQRMESLSSLPALSNLSNPQSYSSASF 442

  Fly   405 HAAANYNAHVAQHQLNDYAAAAAH 428
            ::.    .|...:|.:.|...:.|
Zfish   443 YSL----EHSGHYQYSQYGQNSFH 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	94/123 (76%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	43/52 (83%)
pax3b	NP_001315326.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137820
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1126858at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		mtm6578
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1205
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.880