DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH13

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_003793.2 Gene:MYH13 / 8735 HGNCID:7571 Length:1938 Species:Homo sapiens


Alignment Length:1978 Identity:735/1978 - (37%)
Similarity:1173/1978 - (59%) Gaps:82/1978 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            ||.:.:..:...|:         .|:..:|....:.:|...|:....|:|.|:..:  .|::.|.
Human    20 PEKERIEAQNRPFD---------SKKACFVADNKEMYVKGMIQTRENDKVIVKTLD--DRMLTLN 73

  Fly   120 DD-IQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEK 183
            :| :..||||||||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..:
Human    74 NDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPE 138

  Fly   184 IMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASK 248
            ::..|:|.||.|.|||:|:|:|:||:.||.||::||||.|||||||||.|||:|||:.|.:|   
Human   139 VVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIA--- 200

  Fly   249 PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQAN 313
                                                   |.|.|..|......:|.||.|::|||
Human   201 ---------------------------------------VTGDKKKETQPGKMQGTLEDQIIQAN 226

  Fly   314 PILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQL 378
            |:||||||||||:|||||||||||||:|.|:|.::.|:||||||||||...|...||::|||||:
Human   227 PLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQI 291

  Fly   379 LAGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVS 442
            ::...||..:..::. :...:.|:|.|.:.|..:||..|..||..:::|:|.:||:...|:::..
Human   292 MSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSSEEKVGIYKLTG 356

  Fly   443 AVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKE 506
            ||:.:|:|||:|::..:||. ||.| ||.|..:|:||:..:|.:....||:|||.::|||.|..:
Human   357 AVMHYGNMKFKQKQREEQAE-PDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQ 420

  Fly   507 QVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTN 571
            ||..:|.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:||
Human   421 QVTNSVGALAKAVYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTN 484

  Fly   572 EKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKT 636
            |||||.|||.||:||||||::|||||:|||||:||...|:||:||.||.::|:|||.||||||.:
Human   485 EKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTS 549

  Fly   637 FVDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQ 695
            |.:||...|      ...||..|.  :..|.|::|||||.|||:.|.||.||.|||||.:|.|.|
Human   550 FKNKLYDQHLGKSNNFQKPKPAKG--KAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQ 612

  Fly   696 GSQ---DPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757
            .|.   ..|:.:.:..||.....     .::.|.:.:...|:|||.:::|.|.|||..||:|:|:
Human   613 KSSLKLLSFLFSNYAGAETGDSG-----GSKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPH 672

  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG 822
            ||||:|||..|..|.:|..||:.|||||||||||||||:|||:||.:.:|:|||.:|..:.||:|
Human   673 FVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEG 737

  Fly   823 -FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLAR 886
             |:|.|.|.||::.::::|...:|.|.:|:||:||:|..|||.||.|:..|:.:.||.|||:|.|
Human   738 QFIDSKNASEKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMR 802

  Fly   887 RNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKL 951
            ..::|.:::.::|..||.|..:::.:::|.|..|:.|:||||:..:.|:::...:::.::.:|:|
Human   803 VEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEEL 867

  Fly   952 DTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEE 1016
            .......:|.|.|....|.||..|..|:|:|.|...:|||....|:..|..||..::||..|:||
Human   868 ARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEE 932

  Fly  1017 EEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLL 1081
            |||....|..:|:.||.....|:..:::.|....|::.||...:.|:|...|::...::...||.
Human   933 EEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT 997

  Fly  1082 KEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETE 1146
            ||||.|:|........|..||:|...|.|:.||.|....:||..|.::::.|.:.:|:|||:|.:
Human   998 KEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD 1062

  Fly  1147 VADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLE 1211
            :...:|.:.:......:::.:|.|:|.||:|...:||:|.......||..:||::::.|::|::|
Human  1063 LKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIE 1127

  Fly  1212 AEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGV 1276
            ||...|||.||.|.||:.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||..
Human  1128 AEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192

  Fly  1277 LADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAE 1341
            .|.:|.|.:..:..:.:|::||::.|..|||.|..|:.|..|:|:.:.:::.|:...:|..:..|
Human  1193 AATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVE 1257

  Fly  1342 SQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQL 1406
            .|.:|::.|..:..:...:|..:..:||.:...:::::||.|...|...||...:..||.|.::.
Human  1258 DQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322

  Fly  1407 LEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLA 1470
            :||||:.|..::..|:....:.:.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...
Human  1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387

  Fly  1471 KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKN 1535
            :||||.||:|.:.::..|...:...::...|:|:|:::|.|:||...:||...|....|:|||:|
Human  1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRN 1452

  Fly  1536 FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1600
            |||:|||.|...::...|.:.|::|:|...|::..:....:|..|::|.|..:.|.||.|:.||.
Human  1453 FDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLT 1517

  Fly  1601 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA 1665
            .......||:.|.||.|:.:|.:.::|:...||:|..|:..|...||:::.:..::|:.:|.::.
Human  1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIE 1582

  Fly  1666 KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHA 1730
            |:|..|:.:|...:....|::.||.|.:.|..|:..|||:||||.|:|..:...|:...:..||.
Human  1583 KDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHL 1647

  Fly  1731 KKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDE 1795
            :.:|.|:||:....::|..:.|:|:......||:...|..|:.::...|..:||.||.:|.|..:
Human  1648 RTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLD 1712

  Fly  1796 LAEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELA 1857
            .::.:....::.:.:|:.|::|||.||..:.|:|   :|..|:|   ::::||......:..||.
Human  1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAE---EKAKKAITDAAMMAEELK 1774

  Fly  1858 NEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLL 1922
            .|:..|...|..:..||:..|:|:.:|.|.|.......|..|..||.::..||.:|:.|.|....
Human  1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAE 1839

  Fly  1923 QQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQ 1987
            ..|...|.::|:||:|...|::.:::.:.::.:|||.:::|..||..:|.||:...:.::.|:.|
Human  1840 ALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQ 1904

  Fly  1988 RECEDMIESQEAMNREINSLKTKLRRTG 2015
            .|.|:..|..:....::|.|:.|.|..|
Human  1905 HELEEAAERADIAESQVNKLRAKSRDVG 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 7/36 (19%)
Myosin_head 133..854 CDD:278492 355/732 (48%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 348/720 (48%)
Myosin_tail_1 931..2011 CDD:279860 325/1083 (30%)
Prefoldin 1431..1515 CDD:298833 28/84 (33%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
MYH13NP_003793.2 Myosin_N 36..73 CDD:280832 7/38 (18%)
Myosin_head 88..770 CDD:278492 355/732 (48%)
MYSc_Myh13 100..770 CDD:276887 348/720 (48%)
Actin-binding. /evidence=ECO:0000250 659..681 14/21 (67%)
Actin-binding. /evidence=ECO:0000250 761..775 7/13 (54%)
Myosin_tail_1 850..1927 CDD:279860 325/1079 (30%)
RILP-like <1273..1399 CDD:304877 39/125 (31%)
TMPIT 1744..>1837 CDD:285135 28/95 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1917..1938 5/16 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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