DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and MYO1

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_011888.1 Gene:MYO1 / 856418 SGDID:S000001065 Length:1928 Species:Saccharomyces cerevisiae


Alignment Length:2109 Identity:624/2109 - (29%)
Similarity:1016/2109 - (48%) Gaps:372/2109 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 LVWVPHENQGFVAASI-------KREHGDEVEV------ELAETGKRVMILRDDIQKMNPPKFDK 132
            :||:|.|.:.||...:       .:..|.|.::      :..|....|.:...|:..:||..|||
Yeast    12 IVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDK 76

  Fly   133 VEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRH--- 194
            ||:|:|||.|||.|||:|::.||...|||||||||.|.:|||..|.:|:|..:..|.  .:|   
Yeast    77 VENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYH--NKHNRL 139

  Fly   195 -----------EVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASK 248
                       ::|||:|||.:.||.|:|.:.:|||||.||||||||||||||::|:||.:.:..
Yeast   140 SKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGS 204

  Fly   249 PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQAN 313
            |                                 ..|..|:|..:||        ..|.::||:|
Yeast   205 P---------------------------------SNIAPVSGSSIVE--------SFEMKILQSN 228

  Fly   314 PILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQL 378
            ||||:||||:||:|:|||||||||:|.|:..|.|:||:||.|||||||.:.|...||.:||||||
Yeast   229 PILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQL 293

  Fly   379 LAGATPEQREKFILD--DVKSYAFLSNGSLP-VPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRI 440
            |:|....:.:...|.  :||.|..|||.:.. :||::|...|:..:.::||:|.:.:....||::
Yeast   294 LSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVENFKELLSALNIIGFSKDQIRWIFQV 358

  Fly   441 VSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTK 505
            |:.:||.|:::|..:| .:||:..::..|  |...||:...|...|.|.||.|.|:::|::::..
Yeast   359 VAIILLIGNIEFVSDR-AEQASFKNDVSA--ICSNLGVDEKDFQTAILRPRSKAGKEWVSQSKNS 420

  Fly   506 EQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYT 570
            :|.:|.:.|:::..|||:|.::|:.||::||..... .::||:||:|||||||.|||||||||||
Yeast   421 QQAKFILNALSRNLYERLFGYIVDMINKNLDHGSAT-LNYIGLLDIAGFEIFENNSFEQLCINYT 484

  Fly   571 NEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDK---PGGIMALLDEECWFPKA 632
            ||||||.||:.||:|||.||.:|.|:|.:||:|.|||.|||||:.   |.|::.|||||...||:
Yeast   485 NEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPTGVLPLLDEEAVLPKS 549

  Fly   633 TDKTFVDKLVSAHSMH-PKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            ||::|..||:|....: .||.::..:.  .|.:.||||.|:|:...||.||.||||:|::|||..
Yeast   550 TDESFYSKLISTWDQNSSKFKRSRLKN--GFILKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSS 612

  Fly   697 SQDPFVVNIWK-DAEIVGMA--QQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNF 758
            ||:..:..::: :.|....|  :..:::.:.....|...|:|.|..::||...|::.|.:|:|:|
Yeast   613 SQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKTTSSRHREQQITLLNQLASTHPHF 677

  Fly   759 VRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTP-NVIPKG 822
            |||||||:.|:....:..|:||||||||||||||:.|:|:||||.||||.|||.:|.| |.....
Yeast   678 VRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTT 742

  Fly   823 FMDGKKA-----CEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRG 882
            |....||     ||.::.:|:||:.:|::|.:|:||:|||||.||:::|.|::::::...|..||
Yeast   743 FSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRG 807

  Fly   883 FLARRNYQKRLQQLNAIRIIQRNCAAYLKL-RNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQ 946
            :..|:.....||:|...|:|......|.:| :...|:.|:.::||||..:....:       .|:
Yeast   808 YTVRKEITYHLQKLKKTRVIGNTFRLYNRLVKEDPWFNLFIRIKPLLTSSNDMTR-------TKK 865

  Fly   947 VREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQEL---EDMMQ 1008
            ..|:::.|..:.||.|.|       |..|.|:.|..:.   |.|.::..|...|:.|   |.::.
Yeast   866 FNEQINKLKNDLQEMESK-------KKFLEEKNQKTVN---ELENTQDLLNQEKENLRKNESLLN 920

  Fly  1009 ELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALT 1073
            .::|..|..:::...|..||.::.....::.:.|||   |.||:|    .|...|::.|..|...
Yeast   921 RVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEE---AHQKIQ----GLQETIREREATLEKL 978

  Fly  1074 DDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDR 1138
            ..:|.:|:|:                                   ||:|...:.|:|..:.....
Yeast   979 HSKNNELIKQ-----------------------------------ISDLNCDISKEQSSQSLIKE 1008

  Fly  1139 SKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQL 1203
            ||.|:|.|:..||:.:|.:..::.....:|:..||:|...|:.:::      ....|...|:|.:
Yeast  1009 SKLKLENEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDIKLVTLEK------NCNIAMSRLQSLV 1067

  Fly  1204 AEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEE 1268
            .| ..||      |:|.|..::    |..||.|:|.:........:|.....::||||..|..::
Yeast  1068 TE-NSDL------RSKNENFKK----EKAALNNQLKNKESELLKMKEKIDNHKKELATFSKQRDD 1121

  Fly  1269 ETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQEN 1333
            ....|..:.|:::....|    :.:...|.:|.|.         |..|....|:       .||.
Yeast  1122 AVSEHGKITAELKETRIQ----LTEYKSNYQKIKE---------EYSNFQRETK-------EQEQ 1166

  Fly  1334 DRRRKQAE----SQIAELQVKLAEIERARSELQEKCTKLQQEAENITN-----QLEEAELKASAA 1389
            .:|....|    |:|.||:.:|::.......|.::.:....|. ||::     ...:..|.....
Yeast  1167 KKRNSLVESLNDSKIKELEARLSQEISLNQYLNKRISGNSVET-NISSTRRSTSYSDDPLDKEDI 1230

  Fly  1390 VKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTT 1454
            :|...:::...||..:.||.|..:|..|.|:||..|:.   |.....||.:.|           .
Yeast  1231 IKKYYDLQLAFTEITRNLENEIEEKKNLISRLRFTETR---LASSSFEDQKIK-----------A 1281

  Fly  1455 QMQEIKKKAE-------------EDADLAKELEEGKKRLNKDIEALERQVK-ELIAQND------ 1499
            ||:::||..:             |..|...:.|....:|..:::.|:||:. |..|..|      
Yeast  1282 QMKKLKKLIQDMDPSIPLDSILNEPLDNCPDKESDINKLMLEVDYLKRQLDIETRAHYDAENAIS 1346

  Fly  1500 RLDKSKKKIQSE--LEDATI---ELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTA-- 1557
            .|....:|||.|  |..:.|   :.||...:|..||.|.|...........:.: |.:.||:.  
Yeast  1347 ALHSKFRKIQGESSLSSSDIYKLKFEASEERVKSLEDKLKTMPLRDRTNLPVGD-IIKNRDSISK 1410

  Fly  1558 -EREAREKETKVLSVSRELDEAFDKIEDL-------ENKRKTLQNELDDLANTQGTADKNVHELE 1614
             |.|.|..:.:...:...|:|:..|:..|       ::|...|..:||.|       .|::...|
Yeast  1411 YEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRL-------QKDLESTE 1468

  Fly  1615 KAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVK 1679
            :.|..|.|.:.:.|.|.|...||||..|   |||..::.||: |.|.|               ||
Yeast  1469 RQKELLSSTIKQQKQQFENCMDDLQGNE---LRLREHIHALK-QAEED---------------VK 1514

  Fly  1680 QLRDLETELDEERKQRTAAVASK--KKLEGDLKEIETTMEMH-----NKVKEDALKHAKKLQAQV 1737
            .:..:..:|..:.||:...:..:  ::.:.|::..||.:|:.     .|:..|.|.|.|:..:.|
Yeast  1515 NMASIIEKLKTQNKQKEKLIWEREMERNDSDMQLQETLLELKRVQDVKKILSDDLAHLKERLSAV 1579

  Fly  1738 KDALRDAEEAKAAKEELQA-------LSKE-------AERKVKALEAEVLQLTEDLASSERARRA 1788
            :|..:..:|....||||..       |.||       .|......||::..|.:.|....:....
Yeast  1580 EDRSQYTDEINRLKEELNCSLKAETNLKKEFATLKYKLETSTNDSEAKISDLLKQLDHYTKVVEM 1644

  Fly  1789 AETERDELAEEIANNANKGSLMIDEKRRLEARIATL---EEELEEE------------------- 1831
            ...|:|.::........|...:..|...|:.:|.:|   ::|||.:                   
Yeast  1645 LNNEKDAISLAEKELYQKYEALNTECESLKGKIVSLTKIKQELESDLNQKTDALQISNAALSSST 1709

  Fly  1832 QSNSEV-----LLDRSRKAQLQIEQLTTELA----------NEKSNSQKNEN-----GRALLERQ 1876
            |.|.|:     .|:.:.:.|::......||.          .:|.:.:|.:|     ....|::.
Yeast  1710 QKNKEITEKIKYLEETLQLQMEQNSRNGELVKTLQASCNGYKDKFDDEKQKNIDLYEENQTLQKL 1774

  Fly  1877 NKELKAKLAEI-----ETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKE 1936
            |.:|:.:|..:     :|.::....:.|..|| .:.:||..|:.|      :.|.|:.:::.::|
Yeast  1775 NTDLQLQLKNLHERLSDTTEKNAWLSKIHELE-NMVSLETDLKYE------EMKKNKSLERAVEE 1832

  Fly  1937 L-TMN------IEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMI 1994
            | |.|      ||...::..:.:|...|..::|..|::.:.:.|.|::|.......|:.:.::|.
Yeast  1833 LQTKNSQQTDVIELANKNRSEFEEATLKYEAQISDLEKYISQQELEMKKSIRDNSSYRDKVQEMA 1897

  Fly  1995 ESQE------------AMNREINSLKTKL 2011
            :..|            :.|.:.|:.::|:
Yeast  1898 QEIEFWKSRYESTMIGSKNIDSNNAQSKI 1926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 10/53 (19%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 313/738 (42%)
Myosin_tail_1 931..2011 CDD:460256 258/1213 (21%)
MYO1NP_011888.1 COG5022 2..1691 CDD:227355 581/1865 (31%)
Smc 1607..>1901 CDD:440809 56/300 (19%)

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