DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYO5

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_013827.1	Gene:	MYO5 / 855136	SGDID:	S000004715	Length:	1219	Species:	Saccharomyces cerevisiae

Alignment Length:	1105	Identity:	314/1105 - (28%)
Similarity:	506/1105 - (45%)	Gaps:	190/1105 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 ASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSG 158
            |.:||....:|..|.|:....:.....|..|   .|...|.|:..|:.:::.::..|:|.|:.:.
Yeast     2 AILKRGARKKVHQEPAKRSANIKKATFDSSK---KKEVGVSDLTLLSKISDEAINENLKKRFLNA 63

  Fly   159 LIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCT 223
            .||||.|...:.|||::.|.|||:.:|..|||..|.|||||||||.:|.|.||....|:|.::.:
Yeast    64 TIYTYIGHVLISVNPFRDLGIYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIIS 128

  Fly   224 GESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVV 288
            |||||||||..|:::|::|  |||                 |.:|....|:|.|
Yeast   129 GESGAGKTEAAKRIMQYIA--AAS-----------------STHTESIGKIKDM----------- 163

  Fly   289 NGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIE 353
                                :|..||:||:||.|||::|:||||.||::.|.|:........||.
Yeast   164 --------------------VLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNIT 208

  Fly   354 TYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAF-LSNGSLPVPGVDDYAEF 417
            .|||||.|.:.|.|:||.||||||...||:...|:.|.:...:.|.: .:.|.:....:||..::
Yeast   209 NYLLEKQRVVSQIKNERNFHIFYQFTKGASDAYRQTFGVQKPEQYVYTAAAGCISAETIDDLQDY 273

  Fly   418 QATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTD 482
            |.|:|:|.::|:..|:.:.|||:::|:|..|::.| .|.....|.:.|.:|...:|:||.:....
Yeast   274 QETLKAMRVIGLGQEEQDQIFRMLAAILWIGNVSF-IENEEGNAQVRDTSVTDFVAYLLQIDSQL 337

  Fly   483 MTRAFLTPRIKVGRDFVTKAQTKE------QVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQ 541
            :.:: |..||......:.:.....      |.:...:|:|||.|..:|.|:|:|:|:||......
Yeast   338 LIKS-LVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQAFPGA 401

  Fly   542 GASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDL 606
            ..| |||||:.||||||.|||||:||||.||||||:|.......|||.|:||.|:|..|.: .|.
Yeast   402 EKS-IGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKY-FDN 464

  Fly   607 QPTIDLID--KPGGIMALLDEECWF----PKATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIV 665
            :...|||:  :|.||.|.:::....    ..|.|:.|..:| :..:.:|.|   |.|. ..|.|.
Yeast   465 KVVCDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRL-NLFTTNPHF---DLRS-NKFVIK 524

  Fly   666 HYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRK 730
            ||||.|.|.......||.|.|.:::|.|:..:.:.|:..|:.|.          .|     |..|
Yeast   525 HYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDT----------VD-----RESK 574

  Fly   731 GMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICR 795
            ....|......:....|::||....|:::|.|.||..|.....|...||.|::..|:.|.:||.|
Yeast   575 RRPPTAGDKIIKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRR 639

  Fly   796 QGFPNRIPFQEFRQRYELLTPNVIPKGFM----DGKKACEKMIQALELDSNLYRVGQSKIFFRA- 855
            .||..|..|::|.:|:.||:|:....|..    |...|.:.::|...:....|::|.:.:|.:.
Yeast   640 AGFAYRQVFEKFVERFYLLSPHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTP 704

  Fly   856 GVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCA------AYLKLRN 914
            ..|..||..||....::....|...|.||.||        ::|...|||...      .|.|||:
Yeast   705 ETLFALEHMRDRYWHNMAARIQRAWRRFLQRR--------IDAATKIQRTIRERKEGNKYEKLRD 761

  Fly   915 WQWWRLYTKV---------KPLL------------EVTKQEEKLVQKEDELKQV------REKLD 952
            :.     |||         ..||            ..:|.:...::::..:|:.      .|.|.
Yeast   762 YG-----TKVLGGRKERRSMSLLGYRAFMGDYLSCNESKSKGAYIKRQVSIKEKVIFSIHGEALH 821

  Fly   953 T-LAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELE----T 1012
            | ..::.|..::.:   |:..|||....|..::          ..|...|:.:..::.::    |
Yeast   822 TKFGRSAQRLKKTF---LLTPTTLYIVGQTLVQ----------NAMTYTQDYKIDVRNIQAVSLT 873

  Fly  1013 RIEEEEERV-LALGGE---------KKKLELNIQDLEEQLE-------EEEAARQKLQLEKVQLD 1060
            .::::...: ||..|:         |.:|..:::.|.::::       |.:....||...|.|::
Yeast   874 NLQDDWVAIKLASSGQPDPLINTYFKTELITHLKRLNDKIQIKIGSAIEYQKKPGKLHSVKCQIN 938

  Fly  1061 AKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEER 1125
            ....||.:           :.|...:...|.|..:   ::..:|.:..:.:.:.:.|:.|:...|
Yeast   939 ESAPKYGD-----------IYKSSTISVRRGNPPN---SQVHKKPRKKSSISSGYHASSSQATRR 989

Fly 1126 1125
Yeast 990 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	6/22 (27%)
		Myosin_head	133..854	CDD:278492	247/737 (34%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	244/725 (34%)
		Myosin_tail_1	931..2011	CDD:279860	34/223 (15%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	314/1105 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910