DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYO2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_014971.1	Gene:	MYO2 / 854504	SGDID:	S000005853	Length:	1574	Species:	Saccharomyces cerevisiae

Alignment Length:	1459	Identity:	436/1459 - (29%)
Similarity:	711/1459 - (48%)	Gaps:	225/1459 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 WVPHENQGFVAAS-IKREHGD---EVEVELAETGKRVMILRDDIQK---------MNPPKFDKVE 134
            |.||:..|::.|. ||.|..|   .:|::| |..:.|.:...|:..         .|||..:..|
Yeast    10 WYPHKELGWIGAEVIKNEFNDGKYHLELQL-EDDEIVSVDTKDLNNDKDQSLPLLRNPPILEATE 73

  Fly   135 DMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKL-PIYTEKIMERYKGIKRHEVPP 198
            |:..|:.|||.:|||.||.||....||||||:..:..||:.:: .:||:.:::.|.|.:|.|:.|
Yeast    74 DLTSLSYLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEP 138

  Fly   199 HVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLIN 263
            |:|||.:.|||.|..|:::|:|:.:||||||||.:.|.:::   |.|:.:.:.|..|.|
Yeast   139 HLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMR---YFASVEEENSATVQH------ 194

  Fly   264 FSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKND 328
                                         .||::      |.||::|..|||:||||||||.:||
Yeast   195 -----------------------------QVEMS------ETEQKILATNPIMEAFGNAKTTRND 224

  Fly   329 NSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILD 393
            |||||||::.|.||....|.||.|.|||||:||.:.|...||.:||||||:||...:.:|:..|.
Yeast   225 NSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQLMAGLPAQTKEELHLT 289

  Fly   394 DVKSYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERN 457
            |...|.::: .|...:.|:||..|::.||.::.::|:|.|..:.||:|::|:|..|:::.::.||
Yeast   290 DASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQHQIFKILAALLHIGNIEIKKTRN 354

  Fly   458 NDQATLPDNTVAQKIA-HLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYE 521
            :  |:|..:....|:| .|||:...:..:.....:|....:.:.......|...|.:::||..|.
Yeast   355 D--ASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYS 417

  Fly   522 RMFKWLVNRINRSL--DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 584
            .:|.|||..||..|  .....|.:||||:||:.|||.||.|||||.||||.||||||.||..:|.
Yeast   418 ALFDWLVENINTVLCNPAVNDQISSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFK 482

  Fly   585 LEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            ||||||.:|.|||.||:|. |.||.||||:...||::|||||...|..:|:::..||.......|
Yeast   483 LEQEEYVKEEIEWSFIEFN-DNQPCIDLIENKLGILSLLDEESRLPAGSDESWTQKLYQTLDKSP 546

  Fly   650 K---FMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEI 711
            .   |.|..| |...|.:.|||..|.|....::.||.|.:::..:.:|:.|.:..::||.:..|
Yeast   547 TNKVFSKPRF-GQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLKASTNETLINILEGLE- 609

  Fly   712 VGMAQQALTDT------QFGARTRKGMFRTVSH------LYKEQLAKLMDTLRNTNPNFVRCIIP 764
              .|.:.|.:.      |.|:: :.|..|||:.      ::|:.|.:||:|:.:||.:::|||.|
Yeast   610 --KAAKKLEEAKKLELEQAGSK-KPGPIRTVNRKPTLGSMFKQSLIELMNTINSTNVHYIRCIKP 671

  Fly   765 NHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKA 829
            |.:|.|.:.|..:||.|||..||||.|||...|||:|..|:||..||.:|.|:.........|:.
Yeast   672 NADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIPHEQWDLIFKKKET 736

  Fly   830 CE-------KMI-QALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLAR 886
            .|       ||| .|...|.:.|::|.:||||:||:||:||:.|..|:.:.||..|...|....|
Yeast   737 TEEDIISVVKMILDATVKDKSKYQIGNTKIFFKAGMLAYLEKLRSNKMHNSIVMIQKKIRAKYYR 801

  Fly   887 RNYQKRLQQLNAIRIIQR-----------------NCAAYLKLRNWQWWRLYTKVKPLLEVTKQE 934
            :.|   ||...||:.:|.                 |||..|:.. ::...:...|..:|......
Yeast   802 KQY---LQISQAIKYLQNNIKGFIIRQRVNDEMKVNCATLLQAA-YRGHSIRANVFSVLRTITNL 862

  Fly   935 EKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMAR 999
            :|.::||.:.:|:::            |.:|..|:.        :|:::    ...|.|||.:..
Yeast   863 QKKIRKELKQRQLKQ------------EHEYNAAVT--------IQSKV----RTFEPRSRFLRT 903

  Fly  1000 KQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIK 1064
            |::...:...:..|            ..::||        :||:.:..:...|:....:|:.|:.
Yeast   904 KKDTVVVQSLIRRR------------AAQRKL--------KQLKADAKSVNHLKEVSYKLENKVI 948

  Fly  1065 KYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKD 1129
            :..::||       ..:||.|.:.||..:|...:.|..:..:.|..:|.:|   :.:::.:..||
Yeast   949 ELTQNLA-------SKVKENKEMTERIKELQVQVEESAKLQETLENMKKEH---LIDIDNQKSKD 1003

  Fly  1130 QQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQK 1194
            .:.::..:.:.:..|..:.|.:.:|.:...|.||::.:..|:.|||.||...:.|........|.
Yeast  1004 MELQKTIENNLQSTEQTLKDAQLELEDMVKQHDELKEESKKQLEELEQTKKTLVEYQTLNGDLQN 1068

  Fly  1195 AQRELESQLAEIQEDLEAEKAARAKAEK--VRRDLSEELEALKNELLDSLDTTAAQQELRSKREQ 1257
            ..:.|:.::|.:|..:.......:...:  ::..:........|.:|::.|.:.....|:|
Yeast  1069 EVKSLKEEIARLQTAMSLGTVTTSVLPQTPLKDVMGGGASNFNNMMLENSDLSPNDLNLKS---- 1129

  Fly  1258 ELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVL--EKAKGTL---EAENA 1317
                  :|......||...|: :..::......||::|..|.:...:|  |..:|.|   |..:|
Yeast  1130 ------RSTPSSGNNHIDSLS-VDRENGVNATQINEELYRLLEDTEILNQEITEGLLKGFEVPDA 1187

  Fly  1318 DLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEI------ERARSELQEKCTKLQQEAENIT 1376
            .:|.:|          .:|.....::|  |.:.|:|:      :::.|.|.:..|.:|:    :.
Yeast  1188 GVAIQL----------SKRDVVYPARI--LIIVLSEMWRFGLTKQSESFLAQVLTTIQK----VV 1236

  Fly  1377 NQLEEAELKASAAVKSASNMESQ---LTEAQQLLEEETRQKLGLSSKLRQIESEKE--ALQEQLE 1436
            .||:..:|..|.....|:..|..   :.....:|.||| .|.|::.     |..||  :|..:|:
Yeast  1237 TQLKGNDLIPSGVFWLANVRELYSFVVFALNSILTEET-FKNGMTD-----EEYKEYVSLVTELK 1295

  Fly  1437 EDDEA--KRNYERKLAEVTTQMQEIKKKA 1463
            :|.||  ...|...|.::..|:|   |||
Yeast  1296 DDFEALSYNIYNIWLKKLQKQLQ---KKA 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	13/37 (35%)
		Myosin_head	133..854	CDD:278492	284/748 (38%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	278/736 (38%)
		Myosin_tail_1	931..2011	CDD:279860	109/553 (20%)
		Prefoldin	1431..1515	CDD:298833	12/35 (34%)
		FAM76	<1847..1926	CDD:292665
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	436/1459 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910