DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and XIE

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_175858.1 Gene:XIE / 841898 AraportID:AT1G54560 Length:1529 Species:Arabidopsis thaliana


Alignment Length:1464 Identity:449/1464 - (30%)
Similarity:709/1464 - (48%) Gaps:300/1464 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDK----VEDMAELTCL 142
            ||:...:..::...:::.:|.:|||: |..||::..   .:.|:.|...:.    |:||.:|:.|
plant    16 VWIEDSDVAWIDGLVEKINGQDVEVQ-ATNGKKITA---KLSKIYPKDMEAPAGGVDDMTKLSYL 76

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKGIKRHEVPPHVFAITDS 206
            :|..||.|:|.||....||||:|...:.:||:::|| ||...:|::|||....|:.|||||:.|.
plant    77 HEPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPFGELSPHVFAVADV 141

  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271
            |||.|:.:.:..|||.:|||||||||.||.::::|||:      |..||                
plant   142 AYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYL------GGRAV---------------- 184

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336
                    .:.:|:                    |||:|::||:||||||||||:|:||||||||
plant   185 --------TEGRTV--------------------EQQVLESNPVLEAFGNAKTVRNNNSSRFGKF 221

  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFL 401
            :.|.||..|.||||.:.|||||:||..:.:..||.:|.|| ||..|..|:.||:.|...|::.:|
plant   222 VEIQFDKQGRISGAAVRTYLLERSRVCQISDPERNYHCFY-LLCAAPQEELEKYKLGHPKTFHYL 285

  Fly   402 SNGS-LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPD 465
            :... ..:.|:.|..::.||.::|:|:||:.::..:|||:|:|:|..|:::|.:.:..|.:...|
plant   286 NQSKCFELVGISDAHDYIATRRAMDIVGMSEKEQEAIFRVVAAILHLGNVEFTKGKEVDSSVPKD 350

  Fly   466 -------NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ-VEFAVEAIAKACYER 522
                   ||||:    ||...|..:..| |..|:.|..:.|.|.....| ...:.:.:||..|.|
plant   351 DKSKFHLNTVAE----LLMCDVKALEDA-LCKRVMVTPEEVIKRSLDPQSALISRDGLAKTIYSR 410

  Fly   523 MFKWLVNRINRSL--DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 585
            :|.|||.:||.|:  |.|.|   |.||:||:.|||.|:.|||||.|||:|||||||.||..:|.:
plant   411 LFDWLVEKINVSIGQDATSR---SLIGVLDIYGFESFKTNSFEQFCINFTNEKLQQHFNQHVFKM 472

  Fly   586 EQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            |||||.:|.|:|.:|:| :|.|..:|||: |||||:|||||.|.|||:|.:||.:||......|.
plant   473 EQEEYTKEAIDWSYIEF-VDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETFANKLYQTFKTHK 536

  Fly   650 KFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGM 714
            :|:|... ...|||:.||||.|.|.:..:|.||.|.:......||..|:.|||         ||:
plant   537 RFIKPKL-SRTDFAVAHYAGEVQYQSDLFLDKNKDYVIPEHQDLLGASKCPFV---------VGL 591

  Fly   715 AQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVL 779
            ......:|     ::...|.::...:|.||.:||:||.:|.|:::||:.||:..:....:...::
plant   592 FPPLPEET-----SKSSKFSSIGSRFKLQLQQLMETLNSTEPHYIRCVKPNNLLKPAVFENVNIM 651

  Fly   780 DQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLY 844
            .||||.||||.|||...|:|.|.||.||..|:.||.|..: :|..:.|.|.:|::..:.|..  |
plant   652 QQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLYPRAL-EGNYEEKAAAQKILDNIGLKG--Y 713

  Fly   845 RVGQSKIFFRAGVLAHLEEERDFKIS-----------------------DLIVNFQAFCRGFLAR 886
            :||::|:|.|||.:|.|:..|...:|                       ...::.||.|||.|:.
plant   714 QVGKTKVFLRAGQMAELDARRTMVLSAAAKKIQRRIRTHQAQRRFILLRKATISLQALCRGRLSS 778

  Fly   887 RNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTK-------VKPLLEVTKQEEKLVQKEDEL 944
            :.:....:|..|:: ||:|..           ||:::       |..|:..|........     
plant   779 KIFDNLRRQAAAVK-IQKNAR-----------RLHSRKSYKNLHVAALVVQTGLRAMAAH----- 826

  Fly   945 KQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDM-MQ 1008
            ||.|.:..|.|..|.:.:.:..:|    |...::|:..:.|    .::|.|....::||..: |.
plant   827 KQFRFRKQTKAATTIQAQFRCHRA----TLYFKKLKKGVIL----SQTRWRGKLARRELRQLKMA 883

  Fly  1009 ELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDL--- 1070
            ..||.         ||...|..||..:::|..:.:.|:.:|..|:.||.|   :|||.:..|   
plant   884 SRETG---------ALKEAKDMLEKKVEELTYRAQLEKRSRVDLEEEKNQ---EIKKLQSSLEEM 936

  Fly  1071 -ALTDDQNQKLLKE----KKLLEERANDLSQT--LAEEEEKAKHLAKLKAKHEATISELEERLHK 1128
             ...|:.|..|:||    ||.:||....:::|  |.|:.:|.          ||...|:|.....
plant   937 RKKVDETNGLLVKEREAAKKAIEEAPPVVTETQVLVEDTQKI----------EALTEEVEGLKAN 991

  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDE-----ESAT 1188
            .:|::|.:|.:.||.:    :.:|...:|:.::::.:    |:.::|.:::.|::|     ||..
plant   992 LEQEKQRADDATRKFD----EAQESSEDRKKKLEDTE----KKAQQLQESVTRLEEKCNNLESEN 1048

  Fly  1189 KATAQKA-----------------QRELESQLAEIQEDLEAEKAARAKAEKV-RRDLSEELEALK 1235
            |...|:|                 ||..||....:    :|..:....:..: ||||||      
plant  1049 KVLRQQAVSIAPNKFLSGRSRSILQRGSESGHLSV----DARPSLDLHSHSINRRDLSE------ 1103

  Fly  1236 NELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEG------VLADMRHK-------HSQE 1287
               :|.    ..|:.|..|:::....|.:.:    |.|.|      |.|.:.:|       ...|
plant  1104 ---VDD----KPQKSLNEKQQENQELLIRCI----VQHLGFQGKRPVTACIIYKCLLQWRSFEVE 1157

  Fly  1288 LNSINDQL-----------EN-------LRKAKTVLEKAKGTLEAEN-ADLATELRSVNSS---- 1329
            ..|:.|::           :|       |..|.|:|...:.||:|.. |.:|.:.|..:|:    
plant  1158 RTSVFDRIIQTIGQAIETQDNNNILAYWLSNASTLLLLLQRTLKASGAAGMAPQRRRSSSATLFG 1222

  Fly  1330 RQENDRR-----------------RKQAESQIAELQVK---LAEIERARSELQEKCTKLQQEAEN 1374
            |.....|                 .:|.|::...|..|   .|.:|:....:::   .|::|...
plant  1223 RMTQSFRGTPQGVNLAMINGGVDTLRQVEAKYPALLFKQQLTAYVEKIYGMIRD---NLKKEISP 1284

  Fly  1375 ITNQLEEAELKASAA-VKSASNMESQLTEAQQLL 1407
            :.....:|...:.|: ||.||..... |.|||.|
plant  1285 LLGLCIQAPRTSRASLVKGASRSVGN-TAAQQAL 1317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/34 (26%)
Myosin_head 133..854 CDD:278492 291/733 (40%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 285/721 (40%)
Myosin_tail_1 931..2011 CDD:279860 125/568 (22%)
Prefoldin 1431..1515 CDD:298833
FAM76 <1847..1926 CDD:292665
XIENP_175858.1 Myosin_N 14..51 CDD:280832 9/38 (24%)
MYSc 66..734 CDD:214580 296/745 (40%)
MYSc_Myo11 79..723 CDD:276835 285/721 (40%)
type_I_hlyD 723..>980 CDD:130902 69/303 (23%)
ApoLp-III_like <889..1026 CDD:304399 40/157 (25%)
TPR_MLP1_2 907..1054 CDD:285204 41/167 (25%)
bZIP <1016..1052 CDD:304365 8/39 (21%)
MyosinXI_CBD 1114..1495 CDD:271259 44/212 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - mtm946
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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