DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and ATM2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001078755.1	Gene:	ATM2 / 835516	AraportID:	AT5G54280	Length:	1220	Species:	Arabidopsis thaliana

Alignment Length:	1295	Identity:	374/1295 - (28%)
Similarity:	602/1295 - (46%)	Gaps:	264/1295 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PVSNIHYPKA-----ANYR-------QTRNYLEIAAKMSEEVDRNDPELKY----LSVERNQF-- 67
            |.|....|.|     ||:.       |..:.:.:...:..|.:|.:..:|.    |.|:||.|
plant    42 PNSRARLPSARRSLPANFNVSSVMEDQNGSVVSVTPAVEAESERKEEGVKRKEKDLGVKRNSFGS 106

  Fly    68 --------------------------------------NDPATQAEWT-------QKRL-VWVPH 86
                                                  |.|  ::||.       :|:| ||...
plant   107 KKMRTGLRSESPYAAEKEEEGVKISIAKVSLVENTEEHNKP--ESEWNNNVEYFIKKKLRVWCRV 169

  Fly    87 ENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNI 151
            .|..:....|:....|...|.|: |...|.:..:::...||...:.|||:.:|:.|||.|||:|:
plant   170 SNGQWQLGKIQSTSADTSLVMLS-TANVVKVSTEELFPANPDILEGVEDLIQLSYLNEPSVLYNL 233

  Fly   152 KDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDRE 216
            :.||...:||:.:|...:.|||:|.:.||...::..|:  |:....|||:|:.|:||..|:.:.:
plant   234 RVRYLQDVIYSKAGPVLIAVNPFKNVEIYGNDVISAYQ--KKVMDAPHVYAVADAAYDEMMREEK 296

  Fly   217 DQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQ 281
            :||::.:|||||||||..|..:|:||.:      |.|
plant   297 NQSLIISGESGAGKTETAKFAMQYLAAL------GGG---------------------------- 327

  Fly   282 NQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGF 346
                             :|   .:|.::|:...||||||||||.:|.|||||||.|.|:|.|.|.
plant   328 -----------------SC---GVEYEILKTTCILEAFGNAKTSRNANSSRFGKLIEIHFSAMGK 372

  Fly   347 ISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGS-LPVPG 410
            |.||.:||:||||||.::....||::||||:|.|||:|..:|:..|.....|.:||... |.:.|
plant   373 ICGAKLETFLLEKSRVVQLFNGERSYHIFYELCAGASPILKERLKLKTASEYTYLSQSDCLTIAG 437

  Fly   411 VDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHL 475
            |||..:|...:::.:|:.:..|.....|.:::|||..|::.||...|.:...:..:......|.|
plant   438 VDDAQKFHKLLEAFDIVQIPKEHQERAFALLAAVLWLGNVSFRVTDNENHVEVVADEAVANAAML 502

  Fly   476 LGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKR 540
            :|.:..::.....|.:::.|.|.:.|..|..|.....:.|||..|..:|.|||.:||.:|:..|.
plant   503 MGCNTEELMVVLSTRKLQAGTDCIAKKLTLRQATDMRDGIAKFIYANLFDWLVEQINIALEVGKS 567

  Fly   541 QGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLD 605
            :....|.|||:.|||.|:.|||||.||||.||:|||.||..:|.||||||:.:||:|..::| :|
plant   568 RTGRSISILDIYGFESFKNNSFEQFCINYANERLQQHFNRHLFKLEQEEYEEDGIDWTKVEF-VD 631

  Fly   606 LQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTD--FRGVAD--FAIV 665
            .|..:|||: ||.|:::|||||..||||||.||.:||       .:.:||:  |:|...  |.:.
plant   632 NQECLDLIEKKPIGLLSLLDEESNFPKATDLTFANKL-------KQHLKTNSCFKGERGRAFRVN 689

  Fly   666 HYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRK 730
            ||||.|.|....:|.||.|||..::::||...          |.:::     .|..|:...:::|
plant   690 HYAGEVLYDTNGFLEKNRDPLPADLINLLSSC----------DCQLL-----KLFSTKMRGKSQK 739

  Fly   731 GMF------RTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLE 789
            .:.      :||...:|.||.|||:.|.||:|:|:|||.||.::.....:..|||.||||.||||
plant   740 PLMLSDSTNQTVGTKFKGQLFKLMNKLENTSPHFIRCIKPNSKQLPRVYEEDLVLQQLRCCGVLE 804

  Fly   790 GIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACE-------KMIQALELDSNLYRVG 847
            .:||.|.|:|.|:..|||..||..|         :..||..:       .:::..::...:|:||
plant   805 VVRISRSGYPTRLTHQEFAGRYGFL---------LSDKKVAQDPLSVSIAVLKQYDVHPEMYQVG 860

  Fly   848 QSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKL 912
            .:|::.|.|.:...|:.|. |:...||..|...||.|:|..:|.       :|.:.....:|::.
plant   861 YTKLYLRTGQIGIFEDRRK-KVLQGIVGLQKHFRGHLSRAYFQN-------MRKVTLVLQSYIRG 917

  Fly   913 RNWQWWRLY-TKVK----PLLEVTKQEEKLV-------------------QKEDELKQVREKLDT 953
            .|.:  ||: |:.|    .:.|.:..|...|                   |::.||:.|..|...
plant   918 ENAR--RLFDTEAKFHADSVSEASTDELSAVIHLQSAVRGWLARKHFNSMQRQKELRNVATKSKR 980

  Fly   954 LA--KNTQEYERKYQQALVEKTTLAEQ----LQAEIELCAEAEESRSRLMARKQELEDMMQELET 1012
            .|  :.:::.:...:|..|:.|::::.    |::|..| ::.||..:.|..:.::.|:...|.:.
plant   981 KAGRRISEDKDIPLEQPQVQPTSMSDLQKRILKSEAAL-SQKEEENTALREQLRQFEERWSEYDI 1044

  Fly  1013 RIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKV------QLDAKIKKY---EE 1068
            :::..||          ..:..:..|:..|   .|||:.|..|.:      :.|..|..:   .|
plant  1045 KMKSMEE----------TWQKQMSSLQMSL---AAARKSLAAESITGQAGGRQDTSISPFGYDSE 1096

  Fly  1069 DLALT------------DDQNQKLLKEKKL------LEERANDLSQTLAEEEEKAKHLAKLKAKH 1115
            |...|            .:.|...|:.::|      :...|.:..|.....:|.|:.:.::|...
plant  1097 DTMSTGTPGVRTPTNKFTNGNTPELRIRELNGSLNAVNHLAREFDQRRLNFDEDARAIVEVKLGP 1161

  Fly  1116 EATISELEERLHKDQQQRQESD--RSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREE 1173
            :||       .:..|||..|.:  |.|.:.||...|.|.:|.:.:.::..:.....:..:
plant  1162 QAT-------PNGQQQQHPEDEFRRLKLRFETWKKDYKARLRDTKARLHRVDGDKGRHRK 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/37 (27%)
		Myosin_head	133..854	CDD:278492	267/739 (36%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	260/727 (36%)
		Myosin_tail_1	931..2011	CDD:279860	54/297 (18%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
ATM2	NP_001078755.1	MYSc	208..879	CDD:214580	272/758 (36%)
ATM2	NP_001078755.1	MYSc_Myo8	227..867	CDD:276834	260/727 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I246
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.960