DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and XIH

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_194600.2	Gene:	XIH / 828991	AraportID:	AT4G28710	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1251	Identity:	391/1251 - (31%)
Similarity:	617/1251 - (49%)	Gaps:	230/1251 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDK----VEDMAELTCL 142
            |||......::...:....|.:::|: ..:||.|.|   .:....|...:.    |:||..|..|
plant    12 VWVEDPEVAWIDGEVIEVKGSDIKVK-CTSGKTVAI---KVSSAYPKDVEAPASGVDDMTRLAYL 72

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKGIKRHEVPPHVFAITDS 206
            :|..||.|:|.|:....||||:|...:.|||:::|| :|...:|::|||....|:.||.||:.|:
plant    73 HEPGVLQNMKSRFDINEIYTYTGNILIAVNPFRRLPHLYNNHMMQQYKGAGFGELSPHPFAVADA 137

  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271
            |||.|......||||.:|||||||||.||.::|:||      ..|..||
plant   138 AYRQMKNQGISQSILVSGESGAGKTETTKLLMQYLA------DMGGRAV---------------- 180

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336
                    ::.:|:                    |:::|::||:||||||||||:|:||||||||
plant   181 --------SEGRTV--------------------EKKVLESNPVLEAFGNAKTVRNNNSSRFGKF 217

  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFL 401
            :.|.||..|.||||.|.|||||:||..:.:..||.:|.||.|.| |.||..:|:.|.|.:.:.:|
plant   218 VEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCA-APPEDIKKWKLADPRKFHYL 281

  Fly   402 SNGS-LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPD 465
            :... :.:..:||..|::.|.|:|:::|:.||:..:||::|:|:|..|:::|.:.:..|.:...|
plant   282 NQSQCIELERMDDAKEYRETRKAMDVVGINSEEQEAIFQVVAAILHLGNVEFGKGKEADSSAPKD 346

  Fly   466 NTVAQKIAHLLGLSVTD--MTRAFLTPRIKVGR-DFVTKAQTKEQVEFAVEAIAKACYERMFKWL 527
            :|....:.....|.:.|  .....|..|:.|.| :.:||...:|....:.:|:||..|.|:|.|:
plant   347 DTSNYHLKTAAELFMCDEQALEDSLCKRVIVTRGETITKCLDQESAALSRDALAKTVYSRLFDWI 411

  Fly   528 VNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQR 592
            ||:||.|:.:.. .....||:||:.|||.|:.|||||.|||.|||||||.||..:|.:||:||.:
plant   412 VNKINDSIGQDP-DSEYLIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQDEYNK 475

  Fly   593 EGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSA-----HSMHPKF 651
            |.|:|.:|:| :|.|..:|||: |.|||::||:|.|.||:||.:||.:|:...     |...||.
plant   476 EEIDWSYIEF-VDNQEILDLIEKKAGGIISLLNEACMFPRATHETFAEKMYQTFKDHKHFSKPKL 539

  Fly   652 MKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQ 716
            .:|      ||.|.||||.|.|...::|.||.|.:.....:||..|:..||.:::.     .:|:
plant   540 SRT------DFTICHYAGDVTYQTEQFLEKNKDYVVAEHQTLLNASRCAFVASLFP-----LLAE 593

  Fly   717 QALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQ 781
            .|         .:|..|.::|..:|:||..|::||..|.|:::||:.||:..:....:...||.|
plant   594 DA---------NKKSKFSSISSRFKQQLVTLLETLSTTEPHYIRCVKPNNLLKPLIFENQNVLQQ 649

  Fly   782 LRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDG-------KKACEKMIQALEL 839
            |||.||:|.|||...|||.|..|:||.:|:.:|.|.|:.|. .||       ..||:|:::.:.|
plant   650 LRCGGVMEAIRISCAGFPTRKKFEEFLERFSVLAPEVLDKS-TDGWPLSSTDDVACKKLLEKVAL 713

  Fly   840 DSNLYRVGQSKIFFRAGVLAHLEEERD-----------------------FKISDLIVNFQAFCR 881
            ..  |::|::|:|.|||.:|.|:..|:                       ..:..:..|.||.||
plant   714 QG--YQIGKTKVFLRAGQMADLDARRNEVLGRAASRIQRKFRSYLSRKTFLMLRKVATNMQAVCR 776

  Fly   882 GFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLY-TKVKPLLEVTKQEEKLVQKEDELK 945
            |.|:|..:: .|::..|:..|||:...:|..::::  .|| ..|...|.:     :.:.....|:
plant   777 GQLSRLIFE-GLRRDAAVLEIQRDIRMHLARKSYK--ELYFAAVSIQLGI-----RGMASRGRLR 833

  Fly   946 QVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEES--RSRLMARKQELEDMMQ 1008
            ..|:  |..|...|.:.||:         ||:.....::..|...:|  |:|| |||:..:..|.
plant   834 FQRQ--DKAAIMIQSHCRKF---------LAQLHYQRLKKAAITTQSAWRARL-ARKELRKLKMA 886

  Fly  1009 ELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALT 1073
            ..||.:         |...|.|||..:::|..:|:.|:..|..::..|.|.:||::...|::.|.
plant   887 AKETGV---------LEAAKSKLEKQVEELTWKLQLEKRMRTDMEESKTQENAKLRSALEEMQLQ 942

  Fly  1074 DDQNQKL-LKEKKLLEERA-------------NDLSQTLAEEEEKAKHL-AKLKAKHEATISELE 1123
            ..:.:.| |:|.:..::.|             .:|.:.|..|.||.|.| :.|..|.:.|..:.|
plant   943 FKETKALHLQEVEAAKKMAETVPVLQEVPVVDTELVEKLTSENEKLKSLVSSLDQKIDETEKKFE 1007

  Fly  1124 ERLHKDQQQRQESDRSKRKIETE--VADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEES 1186
            ||      .:...:|.|:.||.|  :.:||       ..|.|:|.::             :|.||
plant  1008 ER------SKINEERLKQAIEAETTIVNLK-------TAVHELQEKI-------------LDVES 1046

  Fly  1187 ATKATAQKA-----------------------------QRELESQLAEIQEDLEAEKAARAKAEK 1222
            ..|...||:                             ..|:|: ||..||.....|..|...::
plant  1047 ENKILRQKSLIQASGHLPPTPVKGSQNGHFSSKESPFNGSEIET-LARTQEQESDAKTRRYHLDR 1110

  Fly  1223 VRRDLSEELEALKNEL 1238
            .|.::...:..:.|.:
plant  1111 QRENIGALINCVVNNI 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	8/34 (24%)
		Myosin_head	133..854	CDD:278492	279/738 (38%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	273/726 (38%)
		Myosin_tail_1	931..2011	CDD:279860	78/356 (22%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
XIH	NP_194600.2	Myosin_N	12..47	CDD:280832	9/38 (24%)
		MYSc	56..738	CDD:214580	284/757 (38%)
		MYSc_Myo11	75..726	CDD:276835	273/726 (38%)
		Apolipoprotein	893..1041	CDD:279749	42/160 (26%)
		DUF4355	893..1011	CDD:290964	32/123 (26%)
		Ax_dynein_light	<978..1023	CDD:287215	15/50 (30%)
		MyosinXI_CBD	1109..1486	CDD:271259	2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910