DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and XIF

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001323600.1	Gene:	XIF / 817748	AraportID:	AT2G31900	Length:	1557	Species:	Arabidopsis thaliana

Alignment Length:	1625	Identity:	469/1625 - (28%)
Similarity:	739/1625 - (45%)	Gaps:	389/1625 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMIL 118
            ||||.::|.|       .|:.:.|..::|..   |...|.|||...:..:.|.
plant    17 DPELAWISGE-------VTEIKGTNAKIVTA---NGKTVVASISSIYPKDTEA------------ 59

  Fly   119 RDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTE 182
                    ||.  .|:||.:|..|:|..||||:..|:....||||:|...:.|||:::|| :|:.
plant    60 --------PPA--GVDDMTKLAYLHEPGVLHNLDCRFALNEIYTYTGNILIAVNPFQRLPHLYSV 114

  Fly   183 KIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAAS 247
            .:||:|||....|:.||:||:.|::||.|:.:...||||.:|||||||||.||.::::||::..
plant   115 HMMEQYKGAAFGELSPHLFAVADTSYRAMINEARSQSILVSGESGAGKTETTKMLMRYLAFMGG- 178

  Fly   248 KPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQA 312
                                                             .|:.:...:|||:|::
plant   179 -------------------------------------------------RSDTEGRSVEQQVLES 194

  Fly   313 NPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQ 377
            ||:||||||||||||:||||||||:.|.||..|.||||.|.|||||:||..:.:..||.:|.||.
plant   195 NPVLEAFGNAKTVKNNNSSRFGKFVEIQFDKRGKISGAAIRTYLLERSRVCQVSDPERNYHCFYM 259

  Fly   378 LLAGATPEQREKFILDDVKSYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIV 441
            |.| |.||:.:||.:.|.:::.:|: .....|..|||..|:..|..:|:|:|:..|..::|||:|
plant   260 LCA-APPEEAKKFKVGDPRTFHYLNQTNCYEVSNVDDAREYLETRNAMDIVGIGQEAQDAIFRVV 323

  Fly   442 SAVLLFGSMKFRQERNNDQATLPDNTV---AQKIAHLLGLSVTDMTRAFLTPRIKVGRD-FVTKA 502
            :|:|..|::.|.:....|.:.|.|:..   .|..|.|| :....|....|..|:.|..| .:||.
plant   324 AAILHLGNVNFIKGEEADSSKLRDDKSRYHLQTAAELL-MCNEKMMEDSLCKRVIVTPDGNITKP 387

  Fly   503 QTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCI 567
            ...|......:|:||..|.|:|.|:|::||.|:.:.. ...|.||:||:.|||.|::||||||||
plant   388 LDPESAASNRDALAKTVYSRLFDWIVDKINSSIGQDP-DAKSLIGVLDIYGFESFKINSFEQLCI 451

  Fly   568 NYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPK 631
            |.|||||||.||..:|.:|||||.||.|.|.:::| :|.|..:|||: |||||:|||||.|.|||
plant   452 NLTNEKLQQHFNQHVFKMEQEEYTREEINWSYVEF-VDNQDVLDLIEKKPGGIIALLDEACMFPK 515

  Fly   632 ATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            :|.:||..|:...:..|.:|.|......| |.:.||||.|.|||.::|.||.|.:.....:||..
plant   516 STHETFAQKMYQTYKGHKRFSKPKLAQTA-FTVNHYAGDVTYSAEQFLDKNKDYVVAEHQALLDA 579

  Fly   697 SQDPFVVNIW----KDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757
            |:..||.|::    :||                  :::..|.::...:|:||..||:||..|.|:
plant   580 SKCSFVANLFPPLPEDA------------------SKQSKFSSIGTRFKQQLQALMETLNTTEPH 626

  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG 822
            ::||:.||...:.|..:...||:||||.||||.|||...|:|.:..|.||..|:.:|..:| |:|
plant   627 YIRCVKPNAVLKPGIFENDNVLNQLRCGGVLEAIRISCAGYPTKRAFDEFLDRFVMLATDV-PEG 690

  Fly   823 FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARR 887
             .|.|.||..:...:.|..  |::|::|||.|||.:|.|:..|...::......|...|.:|.|:
plant   691 -SDEKSACASICNKMGLKG--YQIGKTKIFLRAGQMAELDARRTEVLAGATKLIQRQIRTYLTRK 752

  Fly   888 NY--QKR----LQQLNAIRI----------------IQRNCAAYLKLRNWQWWRLYTKVKPLLEV 930
            .:  |||    :|:|...::                ||:|..|:...:|      |||::....|
plant   753 EFLGQKRATIYMQKLWRAKLARKLYQNMRREAASICIQKNIRAHRARKN------YTKLQASATV 811

  Fly   931 TKQEEKLVQKEDELKQVREKLDTL-AKNTQEYERKYQQALV-----------------EKTTLAE 977
                            ::..|.|: |:|...:.|:.:.|::                 :|.|||.
plant   812 ----------------IQTGLRTMSARNKHRHRRRTKAAIIIQREWRRHQVHEAYKKHKKATLAL 860

  Fly   978 QL--QAEIELCAEAEESRSRLMAR--------KQELEDMMQELETRIEEEEERVLALGGEK---- 1028
            |.  :|::   |..|....|:.||        |.:||..::||..|:|.|:.:...|...|
plant   861 QCLWRAKV---ARKELKNLRMAARETGALKEAKDKLEKRVEELTWRLELEKNQKADLEDAKAQEI 922

  Fly  1029 KKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERAND 1093
            .||:.|:.:|:|:|:|..||              |.:.:|...|..:|...::||..:::....:
plant   923 AKLQNNLTELQEKLDEAYAA--------------IIRDKEAAKLAIEQAPPIIKEVPVVDNTQLE 973

  Fly  1094 LSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERR 1158
            |..  ::..|....:||||.|    |.|.|.:..     ..|:|  .|...||..|.|.:..|.:
plant   974 LLN--SQNNELEVEVAKLKGK----IKEFEVKCF-----ALEND--SRASVTEAEDAKSKAVEFQ 1025

  Fly  1159 VQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELES---QLAEIQEDLEAEKAARAKA 1220
            ..::.:...|:..|.|  ..:||  :::...:|:.:...||.|   ::|.::.:.|..:.....|
plant  1026 EIIERLHTNLSNLESE--NQVLR--QQALAASTSVEEIGELNSLKDKVAILESENETLRRQTESA 1086

  Fly  1221 EKV---------RRDL-----SEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEET- 1270
            ||.         .::|     ::|::|.| |..:.::..|.|..|..::::....|.|.|.:|.
plant  1087 EKTMPPARVFASEKNLENEHQTKEIQATK-EPRNPINVLAKQGSLTDRQQESHEVLMKCLTDERR 1150

  Fly  1271 -VNHEGVLADMRHK-------HSQELNSINDQLEN-------------------LRKAKTVLEKA 1308
             .|.:.|.|.:.:|       ...|..:|.|::.:                   |..:.|:|...
plant  1151 FDNEKSVAAWIVYKALLQWRLFEAEKTNIFDRIVHKIRSSIEKGQDDTRELAYWLTTSSTLLYLL 1215

  Fly  1309 KGTLEAENADLATELRSVNSSRQ----------------------------ENDRRRKQAESQIA 1345
            :.||:..|.:.|...|:.:|...                            .||::..:|:....
plant  1216 QSTLKFSNTNNAASRRNRSSHATLFGRLVQGMQPSSVGLETSSGYSGMAGIPNDQQMVEAKYPAL 1280

  Fly  1346 ELQVKLAE-IERARSELQEKCTK---------------------------------LQQEA---- 1372
            ..:..||. :|:....:::|..|                                 .:|:|
plant  1281 LFKQHLAAYVEKTYGMIRDKLKKEINPLLNLCIHAPRPTRAKTLRDVTKSIHLTTIAKQQASYVQ 1345

  Fly  1373 -ENITNQLEEAELKASAAVKSASNMESQLTEA---------------QQLLEEETRQ-------K 1414
             :||.|:||.     :....:.:::.|.:|..               ..||..|...       |
plant  1346 WQNIVNKLEH-----TLTFMAENHVPSMITRKLFHQVFSYINVQLFNSLLLRRECCSVSNGEYLK 1405

  Fly  1415 LGLSSKLRQIESEKEALQEQLEEDDEAKRN------YERKLAEVTTQMQEIKKKAEEDADLAKEL 1473
            :||          .|..|..|:.||||.|:      :.|:........|:.:|..:|   :|||:
plant  1406 MGL----------HELEQWCLKADDEATRSPWDELQHIRQAVMFLVSHQKTQKSLDE---IAKEI 1457

Fly 1474 1473
plant 1458 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	7/36 (19%)
		Myosin_head	133..854	CDD:278492	288/731 (39%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	282/719 (39%)
		Myosin_tail_1	931..2011	CDD:279860	140/715 (20%)
		Prefoldin	1431..1515	CDD:298833	14/49 (29%)
		FAM76	<1847..1926	CDD:292665
XIF	NP_001323600.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm946
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910