Protein Alignment zip and MYO15B

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001381987.1
• Gene: MYO15B / 80022
• HGNCID: 14083
• Length: 3096
• Species: Homo sapiens
• Alignment Length: 968
• Identity: 284/968 - (29%)
• Similarity: 450/968 - (46%)
• Gaps: 173/968 - (17%)

  Fly    57 LKYLSVER--NQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE-------TG 112
            |..||:|.  .|..||..:.   ..|.:|.|.:..   .|.::|    ::|:.|..       .|
Human   655 LPRLSLETRLQQEGDPGLRG---SLRELWEPEDED---EAVLER----DLELSLRPGLEAPPFPG 709

  Fly   113 KRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKL 177
            .:...|.|.::.|        ||:|.|..:.::|||..:|.|::.|.|||:.|...:|:||::.|
Human   710 AKGRSLGDGLEDM--------EDLARLRLVCDSSVLLCLKKRFHLGRIYTFGGPVLLVLNPHRSL 766

  Fly   178 PIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSIL-----CTGESGAGKTENTKKV 237
            |:::.::...|...|.....||:|||..|||.......:|..||     |:|.||:||||..||:
Human   767 PLFSPEVQASYHPRKALSTTPHIFAIVASAYDLAQNTGQDPCILLCSSHCSGHSGSGKTEAAKKI 831

  Fly   238 IQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQE 302
            :|||:                                   :..|:||           .|..||
Human   832 MQFLS-----------------------------------SLEQDQT-----------GNRECQ- 849

  Fly   303 GELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAK 367
              :|..|    |||.:||:|||:.|.|:||||:...: :...|.|.||::..||||.||.:.||:
Human   850 --VEDML----PILSSFGHAKTILNANASRFGQVFCL-YLQQGVIVGASVSHYLLETSRVVFQAQ 907

  Fly   368 DERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNG-SLPVPGVDDYAEFQATVKSMNIMGMTS 431
            .||:||:||:||||....:||:..|...::|.:|:.| :..:.|.:|..:|:..:|::..:|:..
Human   908 AERSFHVFYKLLAGLDSIERERLSLQGPETYYYLNQGQACRLQGKEDAQDFEGLLKALQGLGLCP 972

  Fly   432 EDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQ--KIAHLLGL-------SVTDMTRAF 487
            |:.|:::.:::|:|..|::.|.......|.....::.|:  ..|.||.:       :||  .|..
Human   973 EELNAVWAVLAAILQLGNICFSSSERESQEVAAVSSWAEIHTAARLLRVPPECLEGAVT--RRVT 1035

  Fly   488 LTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASF--IGILD 550
            .||..:|.|....     |....|.:|:|||.|.|:|..|:.|.|..| ....:|.|.  :.::|
Human  1036 ETPYGQVSRSLPV-----ESAFDARDALAKALYSRLFHRLLRRTNARL-APPGEGGSIGTVTVVD 1094

  Fly   551 MAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI-----DFGLDLQPTI 610
            ..|||...:|..||||.|..:|:||...:..:...|:||.:||.:.|..:     :..|||
Human  1095 AYGFEALRVNGLEQLCNNLASERLQLFSSQMLLAQEEEECRRELLSWVPVPQPPRESCLDL---- 1155

  Fly   611 DLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSA 675
             |:|:|..::::||.:.|..:|||.||:.|....|..||.:.|... .:..|.:.||||.|.|..
Human  1156 -LVDQPHSLLSILDAQTWLSQATDHTFLQKSHYHHGDHPSYAKPRL-PLPVFTVRHYAGTVTYQV 1218

  Fly   676 AKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFR-TVSHL 739
            .|:|.:|.|.|:..:|.:|..||...|.:::::||               .::|.|..| |::..
Human  1219 HKFLNRNRDQLDPAVVEMLGQSQLQLVGSLFQEAE---------------PQSRGGRGRPTLASR 1268

  Fly   740 YKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPF 804
            :::.|..|:..|..::..|::|:.||..|..|..|...|.:||....:||.:......||.|:||
Human  1269 FQQALEDLIARLGRSHVYFIQCLTPNPGKLPGLFDVGHVTEQLHQAAILEAVGTRSANFPVRVPF 1333

  Fly   805 QEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKI 869
            :.|...::.|.... .:...|.:|....:.|.|..:|.||.:|.:|:..:......|||.||.:.
Human  1334 EAFLASFQALGSEG-QEDLSDREKCGAVLSQVLGAESPLYHLGATKVLLQEQGWQRLEELRDQQR 1397

  Fly   870 SDLIVN-----------------FQAFCRGFLARRNYQKR---LQQLNAIRII-----QRNCAAY 909
            |..:|:                 .||..|||.||:.|.:|   |.|||.|.::     ||.  ..
Human  1398 SQALVDLHRSFHTCISRQRVLPRMQARMRGFQARKRYLRRRAALGQLNTILLVAQPLLQRR--QR 1460

  Fly   910 LKLRNWQWW----RLYTKVKPLLEVTKQE---EKLVQKEDELKQVREKLDTLAKNTQE 960
            |:|..||.|    |...:| |.:|:.:.|   |..|.    ||......|.||.:..|
Human  1461 LQLGRWQGWHSSERALERV-PSMELGRLEIPAELAVM----LKTAESHRDALAGSITE 1513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	10/49 (20%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	221/731 (30%)
		Myosin_tail_1	931..2011	CDD:460256	9/33 (27%)
MYO15B	NP_001381987.1	PHA03307	9..>358	CDD:223039
		PRK12678	272..>494	CDD:237171
		MYSc_Myo35	734..1382	CDD:276861	221/731 (30%)
		MyTH4	1598..1700	CDD:459939
		PH-like	2387..2481	CDD:473070
		SH3_MYO15B	2485..2539	CDD:213001
		MyTH4	2643..2781	CDD:214535
		FERM_M	2879..2993	CDD:459788
		FERM_C_MyoXV	2989..3090	CDD:270022