DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYH14

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_011525622.1	Gene:	MYH14 / 79784	HGNCID:	23212	Length:	2043	Species:	Homo sapiens

Alignment Length:	2033	Identity:	1133/2033 - (55%)
Similarity:	1489/2033 - (73%)	Gaps:	63/2033 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LALKSKS--ALHPKSEYPVSNIHYPKAANY-------RQTRNYLEIAAKMSEEVDRNDP----EL 57
            ::||::.  |..|.|:.|.:|..:.::...       |||...:.::....:...|..|    ..
Human     1 MSLKARGTPAAMPGSKEPEANQRWSRSLRTPRPSEGDRQTMAAVTMSVPGRKAPPRPGPVPEAAQ 65

  Fly    58 KYLSVERNQF------NDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVM 116
            .:|...|...      :..:.|.|||.:||||||.|..||.||:::.|..:|.||||||:|:|:.
Human    66 PFLFTPRGPSAGGGPGSGTSPQVEWTARRLVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLR 130

  Fly   117 ILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYT 181
            :.||.||:||||||.|.|||||||||||||||||:::|||||||||||||||||:||||:|||||
Human   131 LPRDQIQRMNPPKFSKAEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYT 195

  Fly   182 EKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA 246
            |.|:|.|:|.|||||||||:|:|:.|||:||.||||||||||||||||||||||||||:||:||:
Human   196 EAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVAS 260

  Fly   247 SKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQ 311
            | |||......||     ||:|..|                               ||||:||||
Human   261 S-PKGRKEPGVPA-----SVSTVSY-------------------------------GELERQLLQ 288

  Fly   312 ANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFY 376
            |||||||||||||||||||||||||||||||.:|:|.|||||||||||||||||||||.:|||||
Human   289 ANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDECSFHIFY 353

  Fly   377 QLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIV 441
            |||.||..:.:...:|:....|.||:||....|| .:...||.|::|:.::|.:.|:..|:.|:|
Human   354 QLLGGAGEQLKADLLLEPCSHYRFLTNGPSSSPG-QERELFQETLESLRVLGFSHEEIISMLRMV 417

  Fly   442 SAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKE 506
            ||||.||::..::|||.||||:||||.|||:..||||.|||.:||.||||||||||:|.||||||
Human   418 SAVLQFGNIALKRERNTDQATMPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKE 482

  Fly   507 QVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTN 571
            |.:||:||:|||.|||:|:|||.|:||:|||:.||||||:||||:||||||:|||||||||||||
Human   483 QADFALEALAKATYERLFRWLVLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTN 547

  Fly   572 EKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKAT 633
            ||||||||||||:|||||||||||.|.|:||||||||.||||::|.   |::|||||||||||||
Human   548 EKLQQLFNHTMFVLEQEEYQREGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKAT 612

  Fly   634 DKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGS 697
            ||:||:|:......||||.: ...|..|||:::||||:|||.|.:||||||||||:|:.:||..|
Human   613 DKSFVEKVAQEQGGHPKFQRPRHLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQS 677

  Fly   698 QDPFVVNIWKDAE-IVGMAQ-QALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760
            .|.....||||.| |||:.| .:|.|...|.|.|:||||||..||||.|::||.||.||||:|||
Human   678 TDRLTAEIWKDVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLYKESLSRLMATLSNTNPSFVR 742

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMD 825
            ||:|||||||||::..||||||||||||||||||||||||||.|||||||||:||||.|||||||
Human   743 CIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRYEILTPNAIPKGFMD 807

  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890
            ||:||||||||||||.||||||||||||||||||.||||||.|::|:||:|||..||:||||.:|
Human   808 GKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQ 872

  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            ||.||.:|:|::|||||||||||:||||||:|||||||:||:|:|.|..:..||::|:|.....|
Human   873 KRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQQSA 937

  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020
            :...|.:.:..|...|:..|||||:||.||||||||:|.||.|||||||.::.|||.|:.||||.
Human   938 REVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEEC 1002

  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085
            ...:..|||:|:.:||:||..||.||.||||||||||..:||:||:||||.|.:|||.||.||:|
Human  1003 SRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERK 1067

  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150
            |||:|..:.|...||||||.|.|.||:.|:||||:::|:||.|:::.|||.::.||:::.|.::|
Human  1068 LLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSEL 1132

  Fly  1151 KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215
            :||:.|::.:.:|::|||.::||||...|.|.::|...:|...|:.||.::.|||.|||||:|:.
Human  1133 QEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1197

  Fly  1216 ARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADM 1280
            ||.||||.||||.||||||:.||.|:||:|.||||||||||||:..|||:|||||..||..:.::
Human  1198 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL 1262

  Fly  1281 RHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIA 1345
            |.:|.|.|..:.:|||..|:.|...||.:..||||.::|..||.|:.::|||.::||::.|.|:.
Human  1263 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1327

  Fly  1346 ELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEE 1410
            |:|.:..:.||||:|..||..:.|.|.||::..|.|||.|.....|..|:.|:||.:||:||:||
Human  1328 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEE 1392

  Fly  1411 TRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEE 1475
            ||.||.|.|::|.:|:|...|:|||||:..|:....|:|.....|:.|.:::.||:|...:..||
Human  1393 TRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEE 1457

  Fly  1476 GKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKIL 1540
            .::|..::.|||.:::.|.....|||::.::::|.||:|||::||.||..|..|||||:.||::|
Human  1458 ARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL 1522

  Fly  1541 AEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGT 1605
            |||||...:..:||:.||.|.||:|.:.||::|.|:|..:..|:||.:.:.|:.||:.|.:::..
Human  1523 AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDD 1587

  Fly  1606 ADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGA 1670
            ..|:|||||:|.|..|....:|:||..||||:|...|||||||||.:|||::|.||||..::|..
Human  1588 VGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1652

  Fly  1671 EEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQA 1735
            ||:||.|.|||||.|.|.||||||||.|||::|||||:|:|::..|....:.||:|:|..:|:||
Human  1653 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQA 1717

  Fly  1736 QVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEI 1800
            |:|:..|:.||.:.::||:.:.::|:|:::|.||||||:|.|:||:|:||||.|:.:|||:|:|:
Human  1718 QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEV 1782

  Fly  1801 ANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQK 1865
            ||.....:.:::|||:||.|:..|||||||||||||:|.||.||..||:|.|||||:.|:|.|.|
Human  1783 ANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAK 1847

  Fly  1866 NENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKM 1930
            .|:||..||||.:||:.:|.|.:...|.:.|.|||.||:|:|..|||||.|.:||:|..|..|:.
Human  1848 AESGRQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRA 1912

  Fly  1931 DKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIE 1995
            :|::||:.:.:|:|||..||.::|::|.|.|:|.|||.|:|.|||..:.:..:|:.|||.||:.|
Human  1913 EKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTE 1977

  Fly  1996 SQEAMNREINSLKTKLRR 2013
            |.|:||||:.:|:.:|||
Human  1978 SAESMNREVTTLRNRLRR 1995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	21/36 (58%)
		Myosin_head	133..854	CDD:278492	495/726 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	484/714 (68%)
		Myosin_tail_1	931..2011	CDD:279860	527/1079 (49%)
		Prefoldin	1431..1515	CDD:298833	27/83 (33%)
		FAM76	<1847..1926	CDD:292665	41/78 (53%)
MYH14	XP_011525622.1	Myosin_head	148..836	CDD:278492	495/725 (68%)
		MYSc_Myh14_mammals	159..836	CDD:276893	484/714 (68%)
		Myosin_tail_1	913..1993	CDD:279860	527/1079 (49%)
		GBP_C	<1661..1761	CDD:303769	51/99 (52%)
		coiled coil	1729..1746	CDD:293879	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1156	1.000	Domainoid score	I16
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2373	1.000	Inparanoid score	I35
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm42309
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.970