DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh10

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_006534552.1	Gene:	Myh10 / 77579	MGIID:	1930780	Length:	2007	Species:	Mus musculus

Alignment Length:	2038	Identity:	1236/2038 - (60%)
Similarity:	1570/2038 - (77%)	Gaps:	66/2038 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 MSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE 110
            |::.....||| :||.|:|....:|||||:||.|:|||:|.|..||.|||||.|.||||.|||||
Mouse     1 MAQRTGLEDPE-RYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMVELAE 64

  Fly   111 TGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYK 175
            .||:.|:.:|||||||||||.|||||||||||||||||||:|||||||||||||||||||:||||
Mouse    65 NGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYK 129

  Fly   176 KLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQF 240
            .||||:|.|:|.|:|.||||:|||::||::||||.||.||||||||||||||||||||||||||:
Mouse   130 NLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQY 194

  Fly   241 LAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGEL 305
            ||:||:|.   .|...|     |....:.|.:|                           .:|||
Mouse   195 LAHVASSH---KGRKDH-----NIPQESPKPVK---------------------------PQGEL 224

  Fly   306 EQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDER 370
            |:||||||||||:||||||||||||||||||||||||.:|:|.||||||||||||||:|||||||
Mouse   225 ERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDER 289

  Fly   371 TFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN 435
            |||||||||:||....:...:|:...:|.|||||.:|:||..|...||.|:::|:|||.:.|:..
Mouse   290 TFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEIL 354

  Fly   436 SIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVT 500
            |:.::||:||.||::.|::|||.|||::|:||||||:.||||::|.:.|||.||||||||||:|.
Mouse   355 SMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQ 419

  Fly   501 KAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQL 565
            |||||||.:|||||:|||.|||:|:|||:|||::||||||||||||||||:||||||||||||||
Mouse   420 KAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQL 484

  Fly   566 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEEC 627
            ||||||||||||||||||||||||||||||||.||||||||||.||||::|.   |::|||||||
Mouse   485 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEEC 549

  Fly   628 WFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIV 691
            |||||||||||:|||.....|.||.| ...:..|||.|:||||:|||.|.:||||||||||:|:.
Mouse   550 WFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVA 614

  Fly   692 SLLQGSQDPFVVNIWKDA----------------------EIVGMAQ-QALTDTQFGA--RTRKG 731
            :||..|.|.||..:|||.                      .|||:.| ..:|:|.||:  :|:||
Mouse   615 TLLHQSSDRFVAELWKDEIQTIQRASFYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKG 679

  Fly   732 MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQ 796
            |||||..||||.|.|||.|||||||||||||||||||||||:|..||||||||||||||||||||
Mouse   680 MFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQ 744

  Fly   797 GFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHL 861
            ||||||.|||||||||:||||.|||||||||:|||:||:|||||.||||:|||||||||||||||
Mouse   745 GFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHL 809

  Fly   862 EEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKP 926
            |||||.||:|:|:.|||.|||:|||:.:.|:.|||:|::::|||||||||||:|||||::|||||
Mouse   810 EEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKP 874

  Fly   927 LLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEE 991
            ||:||:|||:|..|::||.:|:||...:....:|.|||:||.|.||..||||||||.||.|||||
Mouse   875 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 939

  Fly   992 SRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEK 1056
            .|:||.|:|||||:::.:||:|:||||||...|..||||::.:||||||||:|||.|||||||||
Mouse   940 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 1004

  Fly  1057 VQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISE 1121
            |..:|||||.||::.|.:|||.|.:|||||:|:|..:.|..|||||||||:|||::.|.|..||:
Mouse  1005 VTAEAKIKKMEEEVLLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD 1069

  Fly  1122 LEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEES 1186
            |||||.|:::.|||.:::|||::.|..||::|:.|.:.||||::.||.|:||||...|.|.|:|:
Mouse  1070 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQVDELKVQLTKKEEELQGALARGDDET 1134

  Fly  1187 ATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQEL 1251
            ..|..|.|..|||::|:||:|||.|:|||:|.||||.:|||||||||||.||.|:||||||||||
Mouse  1135 LHKNNALKVARELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQEL 1199

  Fly  1252 RSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAEN 1316
            |:|||||:|.|||:||:||.|||..:.|||.:|:..|..:::|||..::.|..|||.|..||.:|
Mouse  1200 RTKREQEVAELKKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1264

  Fly  1317 ADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEE 1381
            .:||.|::.:...:.|::.:||:.::|:.||..|::|.:|.|.||.||..|||.|.:|::..|||
Mouse  1265 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVSTLLEE 1329

  Fly  1382 AELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYE 1446
            ||.|.....|.|:.:||||.:.|:||:|||||||.|||::||:|.||.:||||.||::||::|.|
Mouse  1330 AEKKGIKFAKDAAGLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1394

  Fly  1447 RKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSE 1511
            :::..:.:|:.:.|||.::|....:.|||.||:|.||:|||.::::|.:...|:|:|:|.::|.|
Mouse  1395 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDVEALSQRLEEKVLAYDKLEKTKNRLQQE 1459

  Fly  1512 LEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELD 1576
            |:|.|::|:.||..|..||||||.||::|||||.||.:.|:|||.||.||||||||.||::|.|:
Mouse  1460 LDDLTVDLDHQRQIVSNLEKKQKKFDQLLAEEKGISARYAEERDRAEAEAREKETKALSLARALE 1524

  Fly  1577 EAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLT 1641
            ||.:..|:.|.:.|.|:.:::||.:::....||||||||:|||||.|:.|::.|.|||||:||.|
Mouse  1525 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1589

  Fly  1642 EDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLE 1706
            |||||||||||||:::||||||..::|..|||:|.|:||:|:||.||::|||||..|||||||:|
Mouse  1590 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLLKQVRELEAELEDERKQRALAVASKKKME 1654

  Fly  1707 GDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAE 1771
            .|||::|..:|..||.:::.:|..:|||||:||..|:.|||:|:::|:.|.|||:|:|:|:||||
Mouse  1655 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE 1719

  Fly  1772 VLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSE 1836
            :|||.|:|||||||||.||.||||||:||||:|:..|.::|||||||||||.|||||||||||.|
Mouse  1720 ILQLQEELASSERARRHAEQERDELADEIANSASGKSALLDEKRRLEARIAQLEEELEEEQSNME 1784

  Fly  1837 VLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIAT 1901
            :|.||.||..||::.|.||||.|:|.:||::|.|..||||||||||||.|:|.|.::|.||||:.
Mouse  1785 LLNDRFRKTTLQVDTLNTELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1849

  Fly  1902 LEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLK 1966
            |||||..||||||.|.|||....|..|:.:||:||:.|.:||||||.||:||||:|.|:|:|.||
Mouse  1850 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1914

  Fly  1967 RNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSK 2031
            |.|:|.|||..:....:||.|||.:|..|:.|.::||:::||.:|||.|.|..|||| :|.....
Mouse  1915 RQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSR-SGRRQLH 1978

  Fly  2032 RAGGGGGGDDSSVQDESLDGEDS 2054
            ..|......|...:.::.|..|:
Mouse  1979 IEGASLELSDDDTESKTSDVNDT 2001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	24/36 (67%)
		Myosin_head	133..854	CDD:278492	508/749 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	496/737 (67%)
		Myosin_tail_1	931..2011	CDD:279860	605/1079 (56%)
		Prefoldin	1431..1515	CDD:298833	34/83 (41%)
		FAM76	<1847..1926	CDD:292665	48/78 (62%)
Myh10	XP_006534552.1	Myosin_N	33..72	CDD:397036	26/38 (68%)
		MYSc_Myh10	99..802	CDD:276952	496/737 (67%)
		Myosin_tail_1	879..1959	CDD:396244	605/1079 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1159	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55941
Inparanoid	1	1.050	2332	1.000	Inparanoid score	I35
Isobase	1	0.950	-	0	Normalized mean entropy	S1140
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm44362
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.810