DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo18b

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_083177.2 Gene:Myo18b / 74376 MGIID:1921626 Length:2605 Species:Mus musculus


Alignment Length:2281 Identity:553/2281 - (24%)
Similarity:983/2281 - (43%) Gaps:473/2281 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PKSEYPVSNIHYPKAANYRQTRNYLEIAAKMSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKR 80
            |::|..|.:|  |:....|     |.....|.|:....||:....|.:    :|.|.:..|.:.:
Mouse   501 PQAEGHVESI--PEVVMER-----LSTLRPMEEKQILQDPDRGGQSGD----SDQAYEDRWYEAQ 554

  Fly    81 LVWVPHENQGFVAASI-KREHG----DEVEVELAETGKRVMILRDD--IQKMNPPKFDKVEDMAE 138
            .||:. :..||..|:: |.:.|    ....|.|.....|.:|..|:  :...||.:.|:.||:|.
Mouse   555 KVWLV-QKDGFTLATVLKPDEGTADPPAGRVRLCIDADRTVIEVDEEQVHPANPSELDQAEDLAS 618

  Fly   139 LTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIME-RYKGIKRHEVPPHVFA 202
            |..:||:||::.:..||.:.|.||.||...:.:.|.......:.|:.. |..|:     |.||.:
Mouse   619 LVSVNESSVMNTLLQRYRAQLPYTCSGPDLITLQPQTTTVPSSGKVPRGRQDGL-----PAHVTS 678

  Fly   203 ITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVN 267
            :...||..:|..|.||||:..|.||||||...::|::.|..:|.|                    
Mouse   679 LAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGS-------------------- 723

  Fly   268 TNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSR 332
                                |:|...||            :|.....:|.|||...|..:..::|
Mouse   724 --------------------VDGRVSVE------------KLRATFTVLRAFGCVSTGHSRRATR 756

  Fly   333 FGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDV-K 396
            |...:.::|:|:|.::.|.::|.|||.||..||.:.|..|.:|.|||||...:.|.:..|..: :
Mouse   757 FAMVMSLDFNATGRVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQMAE 821

  Fly   397 SYAF-LSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGS----------- 449
            |.|| :...|.|.........|.....:|.::|::..:..:|:|:::|:...|:           
Mouse   822 SSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQF 886

  Fly   450 MKFRQERNNDQATLPD----NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEF 510
            |:|....:..:|...|    ||...|  |.|...:..||..   |:.:..:|....:..|.....
Mouse   887 MRFEWANHAAEALGCDYEELNTATFK--HHLRQIIEQMTSG---PQRQGLQDNEACSGLKMTGVE 946

  Fly   511 AVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN----------SFEQL 565
            .||.:|...|:.:|..:|:.||||........|| |.::|..||:    |          :||:|
Mouse   947 CVEGMASGLYQELFVAVVSLINRSFSSHHLSMAS-IMVVDTPGFQ----NPRHQGKDRAATFEEL 1006

  Fly   566 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGL-DLQP--TIDLIDK------------ 615
            |.||..|:||.||.|..|:...|.|:.|||.   :.|.| :..|  |:.::|:            
Mouse  1007 CYNYAQERLQLLFYHRTFVSTLERYKEEGIP---VPFDLPESSPGTTVAVVDQNPSQVHLPAGRG 1068

  Fly   616 ---PGGIMALLDEECWFPKATDKTFVDKLVSAH-------SMHPKFMKTDFRGVADFAIVHYAGR 670
               .||:..:||||.....::|.|.:::|.:|.       :..|..|:|..:.: ...:.|..||
Mouse  1069 AEDAGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPL-QCELFHQLGR 1132

  Fly   671 --VDYSAAKWLMK---NMDPL----------NENIVSLLQG-SQDPFVVNIWKDAEIVGMAQQAL 719
              |.|....||.:   |:..|          .|.:.||.|. ::.|.|..  ..|.:.|.:||||
Mouse  1133 DPVRYDLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCR--AVAGLEGTSQQAL 1195

  Fly   720 TDTQFGARTRKGMFRTVSH-----LYKEQLAKLMDTLRNTNPNFVRCIIPNH-EKRAGK------ 772
            ..::...|........|..     ..|.|:..|:..||.:..:|:.|::|.. |.:||:      
Mouse  1196 HRSRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPS 1260

  Fly   773 --------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK-- 821
                          :|.|.:..||..:.:||.:|:.|.|:...:...:||:|:::|.|.::.|  
Mouse  1261 QPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLD 1325

  Fly   822 ---GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGF 883
               ..:|.:|..|::::.|:|:.....||.|::|.:|||::.||.:|:..:|..||.|||.||||
Mouse  1326 LTSEELDERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGF 1390

  Fly   884 LARRNYQK-RLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947
            |:|:.|:| ::::| |...||:|.|.:||:::|.||.|...::|||..|...|:|..||:||..:
Mouse  1391 LSRQEYKKLKIRRL-ATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTLL 1454

  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTT-----LA-EQLQAEIELCAEAEESRSRLMARKQELEDM 1006
            |:||.. ::|::...|:....|..|.|     || |:.:.::...|...|...||.|.::     
Mouse  1455 RQKLQK-SENSRSELRQNTDLLESKITDLTSELADERFKGDVACQALESERAERLQALRE----- 1513

  Fly  1007 MQELETRIEEEEERVLALGGEKKKLELNIQDLE-EQLEEEEAA-----RQKL---QLEKVQLDAK 1062
            :|||:|:.::.::   |||..:|:||...|.:: ..|||:.|.     :.:|   |:|...|..:
Mouse  1514 VQELKTKYQQVQD---ALGEVQKQLEEAQQRIQGANLEEKPAGGADEWQMRLDCAQMENDFLRKR 1575

  Fly  1063 IKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEER-- 1125
            :::.||.|   |.:    :|.:..||::..:| |:..||.:|..|..|.|..|  ...:||:.  
Mouse  1576 LQQCEERL---DSE----MKARTELEQKLGEL-QSAYEEAKKMAHQLKRKCHH--LTWDLEDTRV 1630

  Fly  1126 -LHKDQQQRQESDRSKRKIETEVA----------DLKEQLNER----RVQVDEMQAQLAKREEEL 1175
             |...|.:..|.::.::|.:.::|          .|:|::::.    |.::.::|.||.::|:| 
Mouse  1631 LLENQQSRNHELEKRQKKFDLQLAQALGESMFEKSLREKVSQENNGVRWELGQLQQQLEQKEQE- 1694

  Fly  1176 TQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSE-ELEALKNELL 1239
                            |.|.::|:|....:.:|.|............::..:.| |..||:.:.:
Mouse  1695 ----------------ASKLKQEVERLQGQKRELLSCASVGDQGVASLKERVWELETNALEQQKI 1743

  Fly  1240 DSLDTTAAQQ--ELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAK 1302
            .|......:|  :||.:.|.|:..:|:..:::..:.|..|.|:|....:.|..:..|||...:.|
Mouse  1744 HSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEK 1808

  Fly  1303 TV-------LEKAKGTL--EAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERAR 1358
            .|       ||...|||  :..:.|...|      .|...|.||..|  .::::|:.||.||.::
Mouse  1809 QVALHEKHDLEGLIGTLCDQIGHRDFDVE------KRLRRDLRRTHA--LLSDVQLLLATIEDSK 1865

  Fly  1359 SELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQ 1423
            :.:.      ::|.|.:.:|||::|.|...|:|:...:.:.|......||..||.|..:..:|.:
Mouse  1866 TSIS------KEELEKVHSQLEQSEAKCEDALKTQKVLTADLENMHSELENVTRSKSLVDEQLYR 1924

  Fly  1424 IESEKEALQEQLEED----DEAKRNYERKLAEVTT---QMQEIKKKAEEDADLAKELEEGKKRLN 1481
            ::.|:..|.::::||    ::..:.::..:|:...   |:||::.:.||.....::|.|......
Mouse  1925 LQFERADLLKRIDEDQGDLNDLMQKHKDLIAQSAADIGQIQELQLQLEETKKEKQKLREQLHMAQ 1989

  Fly  1482 KDIEALERQVKE--LIAQNDRL-----DKSK-KKIQSE--------LEDATIELEAQRTKVLELE 1530
            ..|:.||:...|  ::::.:.:     :|:: :|:|.:        |.|:.|::..:.::.::.|
Mouse  1990 LRIQYLEQSTVERAIVSRQEAIICDLENKTEFQKVQIKRFEVLVIRLRDSMIKMGEELSRAVKAE 2054

  Fly  1531 KKQKN----FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKT 1591
            .:|:.    :.:.|.|.||..:::||..:.|.|...|.|..|              |:|...|:|
Mouse  2055 AQQRENSQYYQQRLEELKAEMQELAQREEEASRRCMELEKYV--------------EELATVRQT 2105

  Fly  1592 LQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALR 1656
            ||.:|:....                     ::|:|:|..||:......||..:..::.:.   |
Mouse  2106 LQTDLETSIR---------------------RIADLQAALEEVVSSDSDTESVQTAVDCSS---R 2146

  Fly  1657 SQFERD----LLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTME 1717
            |..|.|    :.::.||:.:.....     .|....|..|.....:|.|.              .
Mouse  2147 SGKEGDNVSVISSQPEGSLQSWMSC-----SLSLATDSVRIPSGQSVVSS--------------S 2192

  Fly  1718 MHN-KVKEDA-----LKHAKKLQAQVKDALRDAEEAKAAKEELQALSKE------------AERK 1764
            .|: :|.|:|     |:.|....:...||.|||  :||....|..:..:            ..||
Mouse  2193 FHSPRVSEEAGDSERLRTASSALSGAWDAARDA--SKAGSASLHPVFPQKPYHLGDGEGFAVHRK 2255

  Fly  1765 VKALEAEVLQLTEDLASSERARRAAET--ERDELAEEIANNANKGSLMIDEKRRLEAR------- 1820
                  ..|:.:..|:||..::|.|.:  .||:|....|    ..|..::|.||..|:       
Mouse  2256 ------STLERSGPLSSSPPSQRTAVSPPSRDKLPSPSA----ALSEFVEELRRKRAQRGQGSTL 2310

  Fly  1821 -----------IATLEEELEEEQSNS---EVLLDRSRKAQLQIEQL---TTELANEKS----NSQ 1864
                       ..|....|...:::|   ::.|....|:.|..|.:   |..|:...|    :|:
Mouse  2311 HLGDGPVLPIFQTTRASSLRRGRASSDEGDLSLKTRVKSPLGAEGIPGATAGLSRSTSLKCISSE 2375

  Fly  1865 KNENGRALLERQNKELKAKLAEIETAQRTKVKAT------IATLEAKIANLEEQLENE-----GK 1918
            ..|:...|.::|.....:..:.:|:...|:.|.:      ..||..:...||..:::.     ||
Mouse  2376 GPEDITLLPDKQKTRFGSCESLLESGPCTRRKLSSPTGLLSPTLRPRRPCLESSVDDAISLELGK 2440

  Fly  1919 ERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQK 1983
            |.|:.|  ||:..        ::.:|....|....::..||.| :..|.:.|:....::|..|..
Mouse  2441 EPLVFQ--NRQFS--------HLMEETLDSDPFSWKLPSLNYR-RQTKVDFDDFLPAIRKSDTPS 2494

  Fly  1984 RKYQRECEDM-------IESQEAMNRE-INSLKTKLRRTGGIGLSSSRLTGTPSS-------KRA 2033
            ....::.::.       .|..||.:|. ::.:||.|:::..:....:.|:.:.||       |..
Mouse  2495 SGAAKDGKEASKHPGVHFEMGEAADRSFLSGIKTILKKSPEVKEDPAHLSDSSSSSSSIVSFKST 2559

  Fly  2034 GGGGGG 2039
            ||.|.|
Mouse  2560 GGTGSG 2565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 12/49 (24%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 206/808 (25%)
Myosin_tail_1 931..2011 CDD:460256 267/1221 (22%)
Myo18bNP_083177.2 PHA03247 <55..472 CDD:223021
COG5022 606..2126 CDD:227355 428/1678 (26%)
MYSc_Myo18 625..1361 CDD:276837 206/808 (25%)
Blue background indicates that the domain is not in the aligned region.

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