DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myo18b

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_083177.2	Gene:	Myo18b / 74376	MGIID:	1921626	Length:	2605	Species:	Mus musculus

Alignment Length:	2281	Identity:	553/2281 - (24%)
Similarity:	983/2281 - (43%)	Gaps:	473/2281 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 PKSEYPVSNIHYPKAANYRQTRNYLEIAAKMSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKR 80
            |::|..|.:|  |:....|     |.....|.|:....||:....|.:    :|.|.:..|.:.:
Mouse   501 PQAEGHVESI--PEVVMER-----LSTLRPMEEKQILQDPDRGGQSGD----SDQAYEDRWYEAQ 554

  Fly    81 LVWVPHENQGFVAASI-KREHG----DEVEVELAETGKRVMILRDD--IQKMNPPKFDKVEDMAE 138
            .||:. :..||..|:: |.:.|    ....|.|.....|.:|..|:  :...||.:.|:.||:|.
Mouse   555 KVWLV-QKDGFTLATVLKPDEGTADPPAGRVRLCIDADRTVIEVDEEQVHPANPSELDQAEDLAS 618

  Fly   139 LTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIME-RYKGIKRHEVPPHVFA 202
            |..:||:||::.:..||.:.|.||.||...:.:.|.......:.|:.. |..|:     |.||.:
Mouse   619 LVSVNESSVMNTLLQRYRAQLPYTCSGPDLITLQPQTTTVPSSGKVPRGRQDGL-----PAHVTS 678

  Fly   203 ITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVN 267
            :...||..:|..|.||||:..|.||||||...::|::.|..:|.|
Mouse   679 LAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGS-------------------- 723

  Fly   268 TNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSR 332
                                |:|...||            :|.....:|.|||...|..:..::|
Mouse   724 --------------------VDGRVSVE------------KLRATFTVLRAFGCVSTGHSRRATR 756

  Fly   333 FGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDV-K 396
            |...:.::|:|:|.::.|.::|.|||.||..||.:.|..|.:|.|||||...:.|.:..|..: :
Mouse   757 FAMVMSLDFNATGRVTAAQLQTVLLENSRVARQPQGEGNFEVFSQLLAGMDVDLRTELNLHQMAE 821

  Fly   397 SYAF-LSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGS----------- 449
            |.|| :...|.|.........|.....:|.::|::..:..:|:|:::|:...|:
Mouse   822 SSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGISEGEQQAIWRVLAAIYHLGAAGACKVGRKQF 886

  Fly   450 MKFRQERNNDQATLPD----NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEF 510
            |:|....:..:|...|    ||...|  |.|...:..||..   |:.:..:|....:..|.....
Mouse   887 MRFEWANHAAEALGCDYEELNTATFK--HHLRQIIEQMTSG---PQRQGLQDNEACSGLKMTGVE 946

  Fly   511 AVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN----------SFEQL 565
            .||.:|...|:.:|..:|:.||||........|| |.::|..||:    |          :||:|
Mouse   947 CVEGMASGLYQELFVAVVSLINRSFSSHHLSMAS-IMVVDTPGFQ----NPRHQGKDRAATFEEL 1006

  Fly   566 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGL-DLQP--TIDLIDK------------ 615
            |.||..|:||.||.|..|:...|.|:.|||.   :.|.| :..|  |:.::|:
Mouse  1007 CYNYAQERLQLLFYHRTFVSTLERYKEEGIP---VPFDLPESSPGTTVAVVDQNPSQVHLPAGRG 1068

  Fly   616 ---PGGIMALLDEECWFPKATDKTFVDKLVSAH-------SMHPKFMKTDFRGVADFAIVHYAGR 670
               .||:..:||||.....::|.|.:::|.:|.       :..|..|:|..:.: ...:.|..||
Mouse  1069 AEDAGGLFWVLDEEVRVQGSSDSTVLERLRAAFEKKKEAGAEEPPSMRTCEQPL-QCELFHQLGR 1132

  Fly   671 --VDYSAAKWLMK---NMDPL----------NENIVSLLQG-SQDPFVVNIWKDAEIVGMAQQAL 719
              |.|....||.:   |:..|          .|.:.||.|. ::.|.|..  ..|.:.|.:||||
Mouse  1133 DPVRYDLTGWLRRAKPNLAALEAPQILQQSKREELQSLFQARAKLPPVCR--AVAGLEGTSQQAL 1195

  Fly   720 TDTQFGARTRKGMFRTVSH-----LYKEQLAKLMDTLRNTNPNFVRCIIPNH-EKRAGK------ 772
            ..::...|........|..     ..|.|:..|:..||.:..:|:.|::|.. |.:||:
Mouse  1196 HRSRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSRLHFIHCLVPTTVESKAGQRTPSPS 1260

  Fly   773 --------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK-- 821
                          :|.|.:..||..:.:||.:|:.|.|:...:...:||:|:::|.|.::.|
Mouse  1261 QPSGDQGVANEPTALDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQVLDPALLKKLD 1325

  Fly   822 ---GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGF 883
               ..:|.:|..|::::.|:|:.....||.|::|.:|||::.||.:|:..:|..||.|||.||||
Mouse  1326 LTSEELDERKVVEELLKTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIVLFQAACRGF 1390

  Fly   884 LARRNYQK-RLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947
            |:|:.|:| ::::| |...||:|.|.:||:::|.||.|...::|||..|...|:|..||:||..:
Mouse  1391 LSRQEYKKLKIRRL-ATLCIQKNLAVFLKVKDWPWWGLLASLRPLLSSTLGTEQLRAKEEELTLL 1454

  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTT-----LA-EQLQAEIELCAEAEESRSRLMARKQELEDM 1006
            |:||.. ::|::...|:....|..|.|     || |:.:.::...|...|...||.|.::
Mouse  1455 RQKLQK-SENSRSELRQNTDLLESKITDLTSELADERFKGDVACQALESERAERLQALRE----- 1513

  Fly  1007 MQELETRIEEEEERVLALGGEKKKLELNIQDLE-EQLEEEEAA-----RQKL---QLEKVQLDAK 1062
            :|||:|:.::.::   |||..:|:||...|.:: ..|||:.|.     :.:|   |:|...|..:
Mouse  1514 VQELKTKYQQVQD---ALGEVQKQLEEAQQRIQGANLEEKPAGGADEWQMRLDCAQMENDFLRKR 1575

  Fly  1063 IKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEER-- 1125
            :::.||.|   |.:    :|.:..||::..:| |:..||.:|..|..|.|..|  ...:||:.
Mouse  1576 LQQCEERL---DSE----MKARTELEQKLGEL-QSAYEEAKKMAHQLKRKCHH--LTWDLEDTRV 1630

  Fly  1126 -LHKDQQQRQESDRSKRKIETEVA----------DLKEQLNER----RVQVDEMQAQLAKREEEL 1175
             |...|.:..|.::.::|.:.::|          .|:|::::.    |.::.::|.||.::|:|
Mouse  1631 LLENQQSRNHELEKRQKKFDLQLAQALGESMFEKSLREKVSQENNGVRWELGQLQQQLEQKEQE- 1694

  Fly  1176 TQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSE-ELEALKNELL 1239
                            |.|.::|:|....:.:|.|............::..:.| |..||:.:.:
Mouse  1695 ----------------ASKLKQEVERLQGQKRELLSCASVGDQGVASLKERVWELETNALEQQKI 1743

  Fly  1240 DSLDTTAAQQ--ELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAK 1302
            .|......:|  :||.:.|.|:..:|:..:::..:.|..|.|:|....:.|..:..|||...:.|
Mouse  1744 HSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLRQLEMQLEQEYEEK 1808

  Fly  1303 TV-------LEKAKGTL--EAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERAR 1358
            .|       ||...|||  :..:.|...|      .|...|.||..|  .::::|:.||.||.::
Mouse  1809 QVALHEKHDLEGLIGTLCDQIGHRDFDVE------KRLRRDLRRTHA--LLSDVQLLLATIEDSK 1865

  Fly  1359 SELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQ 1423
            :.:.      ::|.|.:.:|||::|.|...|:|:...:.:.|......||..||.|..:..:|.:
Mouse  1866 TSIS------KEELEKVHSQLEQSEAKCEDALKTQKVLTADLENMHSELENVTRSKSLVDEQLYR 1924

  Fly  1424 IESEKEALQEQLEED----DEAKRNYERKLAEVTT---QMQEIKKKAEEDADLAKELEEGKKRLN 1481
            ::.|:..|.::::||    ::..:.::..:|:...   |:||::.:.||.....::|.|......
Mouse  1925 LQFERADLLKRIDEDQGDLNDLMQKHKDLIAQSAADIGQIQELQLQLEETKKEKQKLREQLHMAQ 1989

  Fly  1482 KDIEALERQVKE--LIAQNDRL-----DKSK-KKIQSE--------LEDATIELEAQRTKVLELE 1530
            ..|:.||:...|  ::::.:.:     :|:: :|:|.:        |.|:.|::..:.::.::.|
Mouse  1990 LRIQYLEQSTVERAIVSRQEAIICDLENKTEFQKVQIKRFEVLVIRLRDSMIKMGEELSRAVKAE 2054

  Fly  1531 KKQKN----FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKT 1591
            .:|:.    :.:.|.|.||..:::||..:.|.|...|.|..|              |:|...|:|
Mouse  2055 AQQRENSQYYQQRLEELKAEMQELAQREEEASRRCMELEKYV--------------EELATVRQT 2105

  Fly  1592 LQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALR 1656
            ||.:|:....                     ::|:|:|..||:......||..:..::.:.   |
Mouse  2106 LQTDLETSIR---------------------RIADLQAALEEVVSSDSDTESVQTAVDCSS---R 2146

  Fly  1657 SQFERD----LLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTME 1717
            |..|.|    :.::.||:.:.....     .|....|..|.....:|.|.              .
Mouse  2147 SGKEGDNVSVISSQPEGSLQSWMSC-----SLSLATDSVRIPSGQSVVSS--------------S 2192

  Fly  1718 MHN-KVKEDA-----LKHAKKLQAQVKDALRDAEEAKAAKEELQALSKE------------AERK 1764
            .|: :|.|:|     |:.|....:...||.|||  :||....|..:..:            ..||
Mouse  2193 FHSPRVSEEAGDSERLRTASSALSGAWDAARDA--SKAGSASLHPVFPQKPYHLGDGEGFAVHRK 2255

  Fly  1765 VKALEAEVLQLTEDLASSERARRAAET--ERDELAEEIANNANKGSLMIDEKRRLEAR------- 1820
                  ..|:.:..|:||..::|.|.:  .||:|....|    ..|..::|.||..|:
Mouse  2256 ------STLERSGPLSSSPPSQRTAVSPPSRDKLPSPSA----ALSEFVEELRRKRAQRGQGSTL 2310

  Fly  1821 -----------IATLEEELEEEQSNS---EVLLDRSRKAQLQIEQL---TTELANEKS----NSQ 1864
                       ..|....|...:::|   ::.|....|:.|..|.:   |..|:...|    :|:
Mouse  2311 HLGDGPVLPIFQTTRASSLRRGRASSDEGDLSLKTRVKSPLGAEGIPGATAGLSRSTSLKCISSE 2375

  Fly  1865 KNENGRALLERQNKELKAKLAEIETAQRTKVKAT------IATLEAKIANLEEQLENE-----GK 1918
            ..|:...|.::|.....:..:.:|:...|:.|.:      ..||..:...||..:::.     ||
Mouse  2376 GPEDITLLPDKQKTRFGSCESLLESGPCTRRKLSSPTGLLSPTLRPRRPCLESSVDDAISLELGK 2440

  Fly  1919 ERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQK 1983
            |.|:.|  ||:..        ::.:|....|....::..||.| :..|.:.|:....::|..|..
Mouse  2441 EPLVFQ--NRQFS--------HLMEETLDSDPFSWKLPSLNYR-RQTKVDFDDFLPAIRKSDTPS 2494

  Fly  1984 RKYQRECEDM-------IESQEAMNRE-INSLKTKLRRTGGIGLSSSRLTGTPSS-------KRA 2033
            ....::.::.       .|..||.:|. ::.:||.|:::..:....:.|:.:.||       |..
Mouse  2495 SGAAKDGKEASKHPGVHFEMGEAADRSFLSGIKTILKKSPEVKEDPAHLSDSSSSSSSIVSFKST 2559

  Fly  2034 GGGGGG 2039
            ||.|.|
Mouse  2560 GGTGSG 2565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/41 (24%)
		Myosin_head	133..854	CDD:278492	212/820 (26%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	206/808 (25%)
		Myosin_tail_1	931..2011	CDD:279860	267/1221 (22%)
		Prefoldin	1431..1515	CDD:298833	19/106 (18%)
		FAM76	<1847..1926	CDD:292665	21/96 (22%)
Myo18b	NP_083177.2	PHA03247	<55..472	CDD:223021
		COG5022	606..2126	CDD:227355	428/1678 (26%)
		MYSc_Myo18	625..1361	CDD:276837	206/808 (25%)
		CEP170_C	2123..>2365	CDD:373735	55/275 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810