DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001128629.1	Gene:	Myh2 / 691644	RGDID:	620354	Length:	1942	Species:	Rattus norvegicus

Alignment Length:	1975	Identity:	770/1975 - (38%)
Similarity:	1205/1975 - (61%)	Gaps:	74/1975 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.||..:|:.:...:|.|: .|.|..:.:..
  Rat    15 PYLRKSEKERIE----AQNRPFDAKTSVFVAEPKESFVKGTIQSKDAGKVTVK-TEAGATLTVKE 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.|..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
  Rat    75 DQIFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|
  Rat   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..||.|...:|.||.|::.|||
  Rat   198 ----------------------------------TIAVTGEKKKEEVTSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||:.
  Rat   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIT 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..|..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|:::..||:::..|
  Rat   294 SNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNDEKVSIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|.||:..|:.:|...||:|||.::|||.||.||
  Rat   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEYVTKGQTVEQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..||.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
  Rat   423 VTNAVGALAKAMYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.||||||.:|
  Rat   487 KLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLV------SAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||.      ||:...||.:|.  :..|.|:::||||.|||:...||.||.|||||.:|.|.|.
  Rat   552 KNKLYEQHLGKSANFQKPKVVKG--KAEAHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQK 614

  Fly   697 SQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRC 761
            |....:..::..|:.......:....:.||:.:...|:|||.|::|.|.|||..||:|:|:||||
  Rat   615 SSMKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRC 679

  Fly   762 IIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMD 825
            ||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| ::|
  Rat   680 IIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQYID 744

  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890
            .|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||||||..||
  Rat   745 SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGFLARVEYQ 809

  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            |.:::..:|..||.|..|::.:::|.|.:|:.|:||||:..:.|:::...::|.::.:::|....
  Rat   810 KMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSE 874

  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020
            ...:|.|.|....|.||..|..|:|||.|..|:|||...:|:..|.:||..::|:..|.|:|||.
  Rat   875 AKRKELEEKMVSLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 939

  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085
            ...|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||
  Rat   940 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1004

  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150
            .|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...
  Rat  1005 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA 1069

  Fly  1151 KEQL----NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLE 1211
            :|.:    ||:: |:||   :|.|:|.|::....:|::|.|.....||..:||::::.|::|::|
  Rat  1070 QESIMDIENEKQ-QLDE---RLKKKEFEMSNLQSKIEDEQAIGIQLQKKIKELQARIEELEEEIE 1130

  Fly  1212 AEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGV 1276
            ||:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||..
  Rat  1131 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1195

  Fly  1277 LADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAE 1341
            .|.:|.||:..:..:.:|::||::.|..|||.|..::.|..|||:.:.:|:.::...::..:..|
  Rat  1196 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLE 1260

  Fly  1342 SQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQL 1406
            .|::||:.|..|.:|..::|..:..:||.|:...:.||:|.|...|...:.......|:.|.::.
  Rat  1261 DQVSELKSKEEEQQRLINDLTTQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ 1325

  Fly  1407 LEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLA 1470
            ||||.:.|..|:..|:....:.:.|:||.||:.|:|...:|.|::..:::.:.:.|.|.|| ...
  Rat  1326 LEEEVKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRT 1390

  Fly  1471 KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKN 1535
            :||||.||:|.:.::|.|..|:.:.|:...|:|:|:::|:|:||..:::|........|:|||:|
  Rat  1391 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRN 1455

  Fly  1536 FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1600
            |||||||.|...|:...|.:.:::|||...|::..:....:|:.|::|.|:.:.|.||.|:.||.
  Rat  1456 FDKILAEWKQKYEETHAELEASQKEARSLGTELFKMKNAYEESLDQLETLKRENKNLQQEISDLT 1520

  Fly  1601 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA 1665
            .......|.:|||||.|:.:|.:..||:|..||.|..|:..|...||:::.:..::|:.:|.:..
  Rat  1521 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1585

  Fly  1666 KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHA 1730
            |:|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..:||::.
  Rat  1586 KDEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHANRMAAEALRNY 1650

  Fly  1731 KKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDE 1795
            :..|..:||.....::|...:|:|:......||:...|:||:.:|...|..:||:|:.||.|..:
  Rat  1651 RNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1715

  Fly  1796 LAEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELA 1857
            .:|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||.
  Rat  1716 ASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEELK 1777

  Fly  1858 NEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLL 1922
            .|:..|...|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|:|.|..:.
  Rat  1778 KEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE 1842

  Fly  1923 QQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQ 1987
            ..|..||.::::||||...|::|:::.:.::.:|||.:::|..||..:|.||:.....::.||.|
  Rat  1843 AVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLSKFRKLQ 1907

  Fly  1988 RECEDMIESQEAMNREINSLKTKLR 2012
            .|.|:..|..:....::|.|:.|.|
  Rat  1908 HELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	9/36 (25%)
		Myosin_head	133..854	CDD:278492	364/729 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	357/717 (50%)
		Myosin_tail_1	931..2011	CDD:279860	343/1087 (32%)
		Prefoldin	1431..1515	CDD:298833	30/84 (36%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
Myh2	NP_001128629.1	Myosin_N	35..73	CDD:397036	10/38 (26%)
		Motor_domain	100..773	CDD:419868	357/717 (50%)
		Myosin_tail_1	853..1930	CDD:396244	343/1083 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910